• Anand M Ingale Assistant Professor, Vydehi Institute Of Medical Sciences And Research Centre, Bangalore
  • Dr. Venkata Bharatkumar Pinnelli Associate Professor, Department Of Biochemistry, Vydehi Institute of Medical Sciences and Research Centre, #82, EPIP Area, Nallurhalli, Whitefield, Bangalore – 560066, Karnataka
  • Dr. Vijaya Rajendran Professor, Department of Pharmacology. Vydehi Institute of Medical Sciences and Research Centre, #82, EPIP Area, Nallurhalli, Whitefield, Bangalore – 560066, Karnataka





Herbal products are finding increasing demand in the treatment of Peptic ulcer, on account of their better safety and efficacy.


To evaluate the anti-ulcer activity of ethanolic extract of seeds of Vitis Vinifera in Wistar albino rats.


The ethanolic extract of Vitis Vinifera was investigated for its anti-ulcer activity in rats against HCl – Ethanol induced ulcer model. The antiulcer activity was assessed by determining and comparing gastric volume, pH, free and total acidity; ulcer number and its inhibition, ulcer severity and ulcer index.


A significant antiulcer activity was observed. The grape seed 100mg/kg group showed significant [p < 0.05] reduction in ulcer number 30.00 ± 3.23 as compared to the control. The grape seed 200mg/kg showed significant [p < 0.05] reduction in ulcer number 27.33 ± 2.97, free acidity 20.00 ± 2.26, and gastric lesion18.00 ± 2.96 as compared to the control.


This present study indicates that Vitis vinifera seed extract has potential anti ulcer activity in the model tested.

 Keywords: Vitis vinifera, Anti-ulcer, Ethanol, Free acidity, Total acidity


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How to Cite

Ingale, A. M., D. V. B. Pinnelli, and D. V. Rajendran. “EXPERIMENTAL EVALUATION OF THE ANTI-ULCER ACTIVITY OF GRAPE (VITIS VINIFERA) SEED EXTRACT IN WISTAR ALBINO RATS AGAINST HYDROCHLORIC ACID – ETHANOL INDUCED ULCER MODEL”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 6, Nov. 2016, pp. 346-50, doi:10.22159/ajpcr.2016.v9i6.14999.



Original Article(s)