AN EVALUATION OF EFFICACY OF COMMONLY USED FIRST LINE DRUGS IN TERMS OF INTRA OCULAR PRESSURE, OCULAR PERFUSION PRESSURE, AND FIELD OF VISION IN PATIENTS OF PRIMARY OPEN ANGLE GLAUCOMA OF NORTH KARNATAKA

Authors

  • ANAND M INGALE Department of Pharmacology, BLDE DU’s Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India. https://orcid.org/0000-0002-6433-9295
  • RAGHAVENDRA IJERI Department of Ophthalmology, BLDE DU’s Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i3.46803

Keywords:

Intraocular pressure, Beta blocker, Prostaglandin Analogue, Primary Open-angle Glaucoma, Intra Ocular Pressure, Ocular Perfusion Pressure

Abstract

Objective: The objective of the study was to measure the efficacy of commonly used timolol and latanoprost as first line drugs in terms of intra ocular pressure (IOP) and ocular perfusion pressure (OPP).

Methods: This was an open-labeled, randomized, and prospective study conducted in the outpatient department of ophthalmology. Newly diagnosed patients were recruited into the study. A total of 60 patients were recruited into our study and were randomized in a 1:1 ratio into two groups of 30 each to receive either timolol 0.5% eye drops twice daily (Group 1) or latanoprost 0.005% eye drops once daily in the evening for a period of 6 weeks (n=30/group). A baseline general ophthalmic examination was done, and the patients were followed up at week 4 and week 6.

Results: Latanoprost has a greater IOP lowering effect in patients with primary open angle glaucoma as compared to timolol and also concurrently increases Ocular perfusion pressure to a larger extent as compared to timolol.

Conclusion: Latanoprost (left eye: 18.47 and right eye: 18.36) has a greater IOP lowering effect in patients with primary open angle glaucoma as compared to timolol (left eye: 20.4 and right eye: 20.7). Latanoprost (left eye: 57.13 and right eye: 57.20) also concurrently increases ocular perfusion pressure to a larger extent as compared to timolol (left eye: 54.15 and right eye: 55.33).

Downloads

Download data is not yet available.

References

Rao S, Narayanan PV. A comparative clinical trial on the efficacy of latanoprost and timolol in primary open angle glaucoma. J Clin Diagn Res 2016;10:FC13-5.

Soumya R, Jayanthi CR, Sujatha BL. Efficacy and safety of timolol and latanoprost in the treatment of primary open-angle glaucoma. Natl J Physiol Pharm Pharmacol 2017;7:844-50.

Kolli A, Toris CB, Reed DM, Gilbert J, Sit AJ, Gulati V, et al. The effects of topical timolol and latanoprost on calculated ocular perfusion pressure in nonglaucomatous volunteers. J Ocul Pharmacol Ther 2021;37:565-74. doi: 10.1089/jop.2021.0068, PMID 34610254

Tham YC, Lim SH, Gupta P, Aung T, Wong TY, Cheng CY. Inter-relationship between ocular perfusion pressure, blood pressure, intraocular pressure profiles and primary open-angle glaucoma: The Singapore epidemiology of eye diseases study. Br J Ophthalmol 2018;102:1402-6. doi: 10.1136/bjophthalmol-2017-311359, PMID 29331952

Costa VP, Harris A, Anderson D, Stodtmeister R, Cremasco F, Kergoat H, et al. Ocular perfusion pressure in glaucoma. Acta Ophthalmol 2014;92:e252-66. doi: 10.1111/aos.12298, PMID 24238296

Sihota R, Tandon R, editors. The glaucomas. In: Parson’s Diseases of the Eye. 21st ed. Noida: Elsevier; 2011. p. 280-300.

Thomas R, Parikh R, Sood D, Vijaya L, Sekhar GC, Sood NN, et al. Efficacy and safety of latanoprost for glaucoma treatment: A three-month multicentric study in India. Indian J Ophthalmol 2005;53:23-30. doi: 10.4103/0301-4738.15281, PMID 15829743

Stewart WC, Stewart JA, Mychaskiw MA. Cost-effectiveness of latanoprost and timolol maleate for the treatment of glaucoma in Scandinavia and the United Kingdom, using a decision-analytic health economic model. Eye (Lond) 2009;23:132-40. doi: 10.1038/ sj.eye.6702964, PMID 17721497

Luthe R. Timeless timolol? Ophthalmol Manag 2012;16:42-4.

Zhang WY, Po AL, Dua HS, Azuara-Blanco A. Meta-analysis of randomized controlled trials comparing latanoprost with timolol in the treatment of patients with open angle glaucoma or ocular hypertension. Br J Ophthalmol 2001;85:983-90. doi: 10.1136/bjo.85.8.983, PMID 11466259

Orouk MW, Sherif N, Salam A. Intraocular pressure-reducing effect of latanoprost versus timolol in patients with open angle glaucoma and ocular hypertension. Suez Canal Univ J 2000;3:213-7.

Aquino MV, Lat-Luna M. The effect of latanoprost vs timolol on intraocular pressure in patients with glaucoma and ocular hypertension. Asian J Ophthalmol 1999;1:3-7.

Satoskar RS, Rege NN, Bhandarkar SD, editors. Ocular pharmacology. In: Pharmacology and pharmacotherapeutics. 22nd ed. Mumbai: Popular Press Prakasham (P) Ltd.; 2012. p. 1023-32.

Hedman K, Alm A. A pooled-data analysis of three randomized, double-masked, six-month clinical studies comparing the intraocular pressure reducing effect of latanoprost and timolol. Eur J Ophthalmol 2000;10:95-104. doi: 10.1177/112067210001000201, PMID 10887918

Camras CB. Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma: A six-month masked, multicenter trial in the United States. The United States latanoprost study group. Ophthalmology 1996;103:138-47. doi: 10.1016/s0161- 6420(96)30749-5, PMID 8628544

Published

07-03-2023

How to Cite

INGALE, A. M., and R. IJERI. “AN EVALUATION OF EFFICACY OF COMMONLY USED FIRST LINE DRUGS IN TERMS OF INTRA OCULAR PRESSURE, OCULAR PERFUSION PRESSURE, AND FIELD OF VISION IN PATIENTS OF PRIMARY OPEN ANGLE GLAUCOMA OF NORTH KARNATAKA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 3, Mar. 2023, pp. 133-6, doi:10.22159/ajpcr.2023.v16i3.46803.

Issue

Section

Original Article(s)