PHYTOCHEMICAL AND PHARMACOLOGICAL POTENTIAL OF ANNONA SPECIES: A REVIEW

Authors

  • Amudha P Department of Biochemistry, School of Life Sciences, Vels University, Pallavaram, Chennai, Tamil Nadu, India.
  • Vanitha Varadharaj Department of Biochemistry, School of Life Sciences, Vels University, Pallavaram, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i7.18073

Keywords:

Annona muricata, Annona cherimola, Annona reticulata, Annona squamosa, Annona senegalensis, Phytochemicals and pharmacological properties

Abstract

Herbal plants and phytogenic products have used for the treatment of various diseases from ancient times in the folklore medicine worldwide. Crude extracts from plants now play an important and valuable source for natural products that are used in the advancement of medicines against various diseases, for the improvement of pharmaceutical preparations and for novel bioscience research. One such plant genus is Annona, such as Annona muricata, Annona cherimola, Annona reticulata, Annona squamosa, and Annona senegalensis are some species widely cultivating in India and tropical regions of Asia for their edible fruits and medicinal values. These plants have been used for centuries as traditional folk medicine for the treatments of various diseases. The plants are considered to be a good source of vitamins, minerals, plant proteins, fibers, etc., as well as the plant is supposed to have many biological activities. This review describes the morphology and ecology of the plant, its ethnomedicinal uses, pharmacological activities, and phytoconstituents.

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Author Biography

Amudha P, Department of Biochemistry, School of Life Sciences, Vels University, Pallavaram, Chennai, Tamil Nadu, India.

Department of Biochemistry

References

Moghadamtousi S, Fadaeinasab M, Nikzad S, Mohan G, Ali H, Kadir H. Annona muricata (Annonaceae): A review of its traditional uses, isolated acetogenins and biological activities. Int J Mol Sci 2015;16:15625-58.

Natural Resources Conservation Service (NRCS). Plants Profile Annona squamosa L. United States: Department of Agriculture; 2008. p. 4-17.

Germplasm Resources Information Network (GRIN). Taxonomy for Plants. USDA, ARS, National Genetic Resources Program; 1997. p. 7-11.

Wunderlin R, Hansen B. Synonyms of Annona squamosa. Atlas Florida Vasc Plants 2008;4(2):24-7.

Kumar AS, Venkatarathanamma V, Saibabu VN. Phytochemical and phytotherapeutic properties of Annona squamosa, Annona reticulata and Annona muricata: A review. Asian J Plant Sci Res 2015;5(8):28-33.

Orwa C, Mutua A, Kindt R, Jamnadass R, Anthony S. Agroforestree Database: A Tree Reference and Selection Guide version 4.0. 2009 Available from: http://www.worldagroforestry.org/sites/treedbs/treedatabases.asp.

Adewole SO, Caxton-Martins EA. Morphological changes and hypoglycemic effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on pancreatic B-cells of streptozotocin-treated diabetic rats. Afr J Biomed Res 2006;9:173-87.

Popenoe W. The Cherimoya. California Avocado Society Year Book. Vol. 54. 1970. p. 133-9.

Sobiya DR, Jannet JV, Aiyavu C, Panneerselvam K. The hepatoprotective effect of alcoholic extract of Annona squamosa leaves on experimentally induced liver injury in Swiss albino mice. Int J Integr Biol 2009;5(3):182-6.

CSIR. The Wealth of India. Raw Materials. Vol. I. A revised edition. New Delhi: Publications and Information Directorate Council of Scientific and Industrial Research; 1985.

Chetty KM, Sivaji K, Tulasi Rao K. Flowering Plants of Chittoor district, Andhra Pradesh, India. Vol. 169. Tirupati: Students offset Printers; 2008. p. 201.

Palgrave KC. Trees of Southern Africa. Cape Town: Struik Publishers; 2002.

Adewole, S, Ojewole J. Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats. Afr J Tradit Complement Altern Med 2009;6:30-41.

Wu FE, Gu ZM, Zeng L, Zhao GX, Zhang Y, McLaughlin JL, et al. Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata. J Nat Prod 1995;58(6):830-6.

Sahpaz S, Gonzalez MC, Hocquemiller R, Zafra-Polo MC, Cortes D. Annosenegalin and anagalene: Two cytotoxic monotetrahydrofuran acetogenins from Annona senegalensis and Annona cherimola. Phytochemistry 1996;42(1):103-7.

Amoo IA, Emenike AE, Akpambang VO. Compositional evaluation of Annona cherimola (Custard apple) fruit. Trends Appl Sci Res 2008;2:216-20.

Himesh S, Akand S, Sarvesh S. Quantification of ascorbic acid in leaves of Annona squamosa. Int J Pharm Pharm Sci 2011;4(3):144-7.

Dambatta S, Aliyu B. A survey of major ethno medicinal plants of Kano North, Nigeria, their knowledge and uses by traditional healers. Bayero J Pure Appl Sci 2011;4(2):28-34.

Ofukwu R, Ayoola A, Akwuobu C. Medicinal plants used in the management of tuberculosis in humans and animals by Idoma tribe of North Central Nigeria. Niger Vet J 2008;29(2):25-30.

Faleyimu O, Ahmad I, Akinyemi O. Herbal approach to the treatment of chicken pox: A case study of Giwa local government, Kaduna state. Niger Int J Biomed Health Sci 2010;6(1):13-8.

Ahombo G, Ampa R, Diatewa M, Mpati J, Abena A, Ouamba J. Investigating on related diabetes therapeutic plants used in traditional medicine at Brazzaville. J Med Plants Res 2012;6(44):5630-9.

Traore MS, Baldé MA, Diallo MS, Baldé ES, Diané S, Camara A, et al. Ethnobotanical survey on medicinal plants used by Guinean traditional healers in the treatment of malaria. J Ethnopharmacol 2013;150(3):1145-53.

National Research Council. Custard apples (Annona species). In: Lost Crops of Africa: Vol. III. Washington DC: National Academic Press; 2008. p. 244-6.

Goli J, Ogaji O, Tor-Anyin T, Igoli N. Traditional medicine practice amongst the Igede people of Nigeria. Part II. Afr J Tradit CAM 2005;2(2):134-52.

Salifou S, Offoumon O, Gouissi F, Pangui L. Endogenous recipes for controlling arthropod ectoparasites of domestic poultry. Rev Bras Parasitol Vet Jaboticabal 2012;22(1):119-23.

Foong CP, Hamid RA. Evaluation of anti-inflammatory activities of ethanolic extract of Annona muricata leaves. Rev Bras Farmacogn 2012;22:6.

Verma MA, Kumar PA, Kavitha D, Anurag KB. Anti-denaturation and antioxidant activities of Annona cherimola in-vitro. Int J Pharm Biosci 2011;2(2):1-6.

Chen CY, Wu TY, Chang FR, Wu TC. Lignans and Kauranes from the stems of Annona cherimola. J Chin Chem Soc 1998;45(5):629-34.

Wele A, London C, Labbe H, Vovelle F, Zang Y, Bodo B. Sequence and solution structure of cherimolacyclopeptide A and B, novel cyclooctapeptides from the seeds of Annona cherimola. Tetrahedron 2004;60:405-14.

Ferreira L, Perestrelo R, Camara JS. Comparative analysis of the volatile fraction from Annona cherimola Mill. Cultivars by solid phase micro extraction and gas chromatography-quadrupole mass spectrometry detection. Talanta 2009;77:1087-96.

Rani DJ, Devi RR, Shri MV. Phytochemical screening and antimicrobial activity of various solvent extracts of Annona reticulata leaves. IJSIT 2013;2(5):347-58.

Yang TH, Chi-Ming C. Structure of squamolone, a novel diazepine from Annona squamosa L. J Chin Chem Soc (Taipei) 1972;19:149-51.

Chang FR, Chen JL, Chiu HF, Wu MJ, Wu YC. Acetogenins from seeds of Annona reticulata. Phytochemistry 1998;47(6):1057-61.

Maeda U, Hara N, Fujimoto Y, Shrivastava A, Gupta YK, Sahai M. N-fatty acyl tryptamines from Annona reticulata. Phytochemistry 1993;34:1633-5.

Hisham A, Sunitha C, Sreekala U, Pieters L, Bruyne DT, Heuvel VH, et al. Reticulacinone, an acetogenin from Annona reticulata. Phytochemistry 1994;35:1325-9.

Etse JT, Waterman PG. Chemistry in the Annonaceae, XXII: 14-Hydroxy-25-desoxyrollinicin from the stem bark of Annona reticulata. J Nat Prod 1986;49:684-6.

Saad JM, Hui YH, Rupprecht JK, Anderson JE, Kozlowski JF, Zhao GX, et al. Reticulatacin: A new bioactive acetogenin from Annona reticulate (Annonaceae). Tetrahedron 1991;47:2751-6.

Awa EP, Ibrahim S, Ameh DA. GC/MS analysis and antimicrobial activity of diethyl ether fraction of methanolic extract from the stem bark of Annona senegalensis pers. IJPSR 2012;3(11):4213-8.

Pandey N, Barve D. Phytochemical and pharmacological review on Annona squamosa Linn. Int J Res Pharm Biomed Sci 2011;2:2229-3701.

Lapornik B, Prosek M, Wondra AG. Comparison of extracts prepared from plant by-products using different solvents and extraction time. J Food Eng 2005;71:214-22.

Yisa J, Egila J, Darlinton A. Chemical composition of Annona senegalensis from Nupe land, Nigeria. Afr J Biotech 2010;9(26):4106-9.

Ogunlesi M, Okiei W, Ofor E, Awonuga O. Determination of the concentrations of zinc and vitamin C in oysters and some medicinal plants used to correct male factor infertility. J Nat Prod 2009;2:89-97.

Okoye TC, Akah PA, Okoli CO, Ezike AC, Omeje EO, Odoh UE. Antimicrobial effects of a lipophilic fraction and Kaurenoic acid isolated from the root bark extracts of Annona senegalensis. Evid Based Complement Alter Med 2012;25-34.

Philipov S, Kande KM, Machev K. Alkaloids of Annona senegalensis. Fitoterapia 1995 66:275-6.

Bamba PD, Abalansard G, Maillard C, Demenil G, Gayte-Sorbier A. Characterization of amino acids in the stem bark of Annona senegalensis Pers. Plante Med Phytother 1984;18:36-45.

Mackie A, Misra AL. Chemical investigation of the leaves of Annona senegalensis and constituents of the leaf wax. J Sci Food Agric 1956;7:203.

Ekundayo O, Oguntimein B. Composition of the essential oils of Annona senegalensis Var. Senegalensis. Plant Med 1986;52:202-4.

Adesogan EF, Durodola JI. Antitumor and antibiotic principles of Annona senegalensis. Phytochemistry 1976;15:1311-2.

Pourmorad F, Hosseininelir SJ, Shahabimajd N. Antioxidant activity, phenol and flavonoid content of some selected Iranian medicinal plants. Afr J Biotechnol 2006;5:1142-5.

Okechukwu PC, Okwesili FC, Parker EJ, Abubakar B, Emmanuel CO, Christian EO. Phytochemical and acute toxicity studies of Moringa oleifera ethanol leaf extract. Int J Life Sci Biotechnol Pharm Res 2013;2(2):66-71.

Rice-Evans CA, Miller NJ, Bolwell PG, Bramley PM, Pridham JB. Therelative activities of plant-derived polyphenolic flavonoid. Free Radical Res 1995;22:375-83.

Jyothi BA, Venkatesh K, Chakrapani P, Rani AR. Phytochemical and pharmacological potential of Annona cherimola-A review. Int J Phytomed 2011;3:439-47.

Sovia E, Ratwita W, Wijayanti D, Novianty DR. Hypoglycemic and hypolipidemic effects of Annona muricata L. leaf ethanol extract. Int J Pharm Pharm Sci 2017;9(3):170-4.

Roa R, Babu M, Rao MR. Saponins as anti-carcinogens. J Nutr 1995;125:717-24.

Okhale S, Akpan E, Fatokun OT, Eseivo KB, Esievo B, Kunle OF. Annona senegalensis Persoon (Annonaceae): A review of its ethnomedicinal uses, biological activities and phytocompounds. J Pharmacogn Phytochem 2016;5(2):211-9.

Baskar R, Rajeswari V, Kumar TS. In vitro antioxidant studies in leaves of Annona species. Indian J Exp Biol 2007;45(5):480-5.

Yuan SS, Chang HL, Chen HW, Yeh YT, Kao YH, Lin KH, et al. Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. Life Sci 2003;72(25):2853-61.

Yuan SS, Chang HL, Chen HW, Kuo FC, Liaw CC, Su JH, et al. Selective cytotoxicity of squamocin on T24 bladder cancer cells at the S-phase via a Bax-, Bad, and caspase-3-related pathways. Life Sci 2006;78(8):869-74.

Suresh HM, Shivakumar B, Shivakumar SI. Inhibitory potential of the ethanol extract of Annona reticulata Linn against melanoma tumor. J Nat Pharm 2011;2:168-72.

Mondal S, Mondal N, Mazumder U. In vitro cytotoxic and human recombinant caspase inhibitory effect of Annona reticulata leaves. Indian J Pharmacol 2007;39:253-4.

Kaleem M, Asif M, Ahmed QU, Bano B. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J 2006;47(8):670-5.

Thang TD, Kuo PC, Huang GJ, Hung NH, Huang BS, Yang ML. Chemical constituents from the Leaves of Annona reticulata and their inhibitory effects on no production. Molecules 2013;18:4477-86.

Rout SP, Kar DM, Mohapatra SB, Swain SP. Anti-hyperglycemic effect Annona reticulata L. leaves on experimental diabetic rat model. Asian J Pharm Clin Res 2013;6(1):56-60.

Madhuri S, Pandey G. Some anticancer medicinal plants of foreign origin. Curr Sci 2009;96:779-83.

Shirwaikar A, Rajendran K, Kumar CD, Bodla R. Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide Type 2 diabetic rats. J Ethnopharmacol 2004;91(1):171-5.

Padhi LP, Panda SK, Satapathy SN, Dutta SK. In vitro evalution of antibacterial potential of Annona squamosa Linn. and Annona reticulata L. from Simlipal biosphere reserve, Orissa, India. J Agric Technol 2011;7(1):133-42.

Pardhasaradhi BV, Reddy M, Mubarak AA, Kumari AL, Khar A. Antitumour activity of Annona squamosa seed extracts is through the generation of free radicals and induction of apoptosis. Indian J Biochem Biophys 2004;41:167-72.

Ashok K, Pardhasaradhi BV, Madhurima R, Mubarak AA, Leela AK. Differential cytotoxic effects of Annona squamosa seed extracts on human tumour cell lines: Role of reactive oxygen species and glutathione. J Biosci 2005;30(2):237-44.

Suresh K, Mamoharan S, Panjamurthy K, Kavitak K. Chemopreventive and antilipidperoxidative efficiency of Annona squamosa bark extract. Pak J Biol Sci 2006;9(14):2600-5.

Mohamed TS, Madhusudana CC, Ramkanth S, Rajan VS, Mahesh KK, Gauthaman K. Hepatoprotective herbs- A review. Int J Res Pharm Sci 2010;1(1):1-5.

Joseph MJ, Ester I, Joseph ON. Mosquito larvicidal and cytotoxic activities of 3 Annona species and isolation of active principles. J Med

Plant Res 2009;3(9):674-80.

Ekramul H, Motiur R, Ekramul MI, Parvin MS. Pesticidal activity of pure compound annotemoyin-1 isolated from chloroform extract of the plant Annona squamosa Linn. Against Tribolium castaneum (Herbst). Pak J Biol Sci 2003;6(12):1088-91.

Panda S, Kar A. Annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: Possible involvement of quercetin. Phytomedicine 2007;14(12):799-805.

Ahir A, Satti GM, Khalid SA. Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell J Ethnopharmacol 1999;64(3):227-33.

Mishar A, Dogra JV, Singh JN, Jha OP. Post-coital antifertility activity of Annona squamosa and Ipomoea fistulosa. Planta Med 1979;35(3):283-5.

Souza MC, Bevilaqa CM, Morais SM, Cicero TC. Anthelmintic acetogenin from Annona squamosa L. seeds. Annu Brazil Acad Sci 2008;80(2):271-7.

Published

01-07-2017

How to Cite

P, A., and V. Varadharaj. “PHYTOCHEMICAL AND PHARMACOLOGICAL POTENTIAL OF ANNONA SPECIES: A REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 7, July 2017, pp. 68-75, doi:10.22159/ajpcr.2017.v10i7.18073.

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Section

Review Article(s)