CLOPIDROGEL INDUCED LEUKOCYTOCLASTIC VASCULITIS

Navin Patil; Balaji O; Karthik Rao; Talha A; Chaitan Chaitan

doi:10.22159/ajpcr.2017.v10i7.18683

Authors

Navin Patil Department of Pharmacology, Kasturba Medical College, Manipal, Udupi, Karnataka, India.
Balaji O Department of Pharmacology, Kasturba Medical College, Manipal, Udupi, Karnataka, India.
Karthik Rao Department of Internal Medicine, Kasturba Medical College, Manipal, Udupi, Karnataka, India.
Talha A Intern, Kasturba Medical College, Manipal
Chaitan Chaitan Intern, Kasturba Medical College, Manipal

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i7.18683

Keywords:

Clopidogrel, Vasculitis, Angioplasty, Adverse drug reaction

Abstract

Cutaneous adverse drug reactions are very common in a hospital setting while treating patients. Drug-induced vasculitis is a very common form of vasculitis affecting all age groups, and many drugs have been implicated in causing vasculitis. Clopidogrel is an antiplatelet drug used in the management as well as prevention of coronary artery disease. It is known to cause various side effects ranging from bleeding, gastrointestinal disturbances, to skin rashes. Leukocytoclastic vasculitis is a form of hypersensitivity vasculitis and is very rarely seen with clopidogrel. Hence, we report a case of clopidogrel-induced leukocytoclastic vasculitis in an old male patient after coronary stenting.Â

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References

Radic M, Kaliterna DM, Radic J. Drug-induced vasculitis: A clinical and pathological review. Neth J Med 2012;70(1):12-7.

Einhorn J, Levis JT. Dermatologic diagnosis: Leukocytoclastic vasculitis. Perm J 2015;19(3):77-8.

Erpolat S, Nazli Y, Colak N, Yenidunya S. Leucocytoclastic vasculitis associated with clopidogrel. Cutan Ocul Toxicol 2012;31(2):171-3.

Kumar M, Dahiya V, Mishra S, Sharma D, Mishra N, Lahkar M. Cardiovascular disease prevalence and drug utilization patterns at a tertiary care hospital in Northeastern India. Int J Pharm Pharm Sci 8(6):116-9.

Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30(2):239-45.

Hartwig SC, Siegel J, Schneider PJ. Preventability and severity assessment in reporting adverse drug reactions. Am J Hosp Pharm 1992;49(9):2229-32.

Schumock GT, Thornton JP. Focusing on the preventability of adverse drug reactions. Hosp Pharm 1992;27(6):538.