CASE REPORT ON DOCETAXEL-INDUCED INTERSTITIAL LUNG DISEASE

Remya Antony; Shiva Krishna; Jini James; Akhilesh Kunoor; Meenu Vijayan

doi:10.22159/ajpcr.2017.v10i10.19043

Authors

Remya Antony Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.
Shiva Krishna Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.
Jini James Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.
Akhilesh Kunoor Department of Pulmonary Medicine, Amrita Institute of Medical Sciences, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.
Meenu Vijayan Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i10.19043

Keywords:

Docetaxel, Interstitial lung disease, Naranjo adverse drug reaction probability scale

Abstract

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Â Docetaxel belongs to taxane family of antineoplastic agents that are indicated for the treatment of locally advanced or metastatic non-small-cell lung cancer. Docetaxel is associated with many adverse effects, and pulmonary reaction has an incidence of 41%. However, interstitial pulmonary disease is found to occur only in <1% of the population as per the post-marketing surveillance reports. Here, we report a case of docetaxel-induced interstitial lung disease (ILD). The patient information and details were collected using the hospital information system. The adverse drug reaction (ADR) of ILD occurred after 5 cycles of chemotherapy with docetaxel at a dose of 60 mg/m2 that is 80 mg IV. The causality of the event in our case was assessed using the Naranjo ADR probability scale which marked a score of 7 (probable). It is necessary that all physicians be aware of the reaction and to closely monitor clinicoradiological and functional status of the patients at regular intervals after administration of docetaxel.

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Author Biographies

Remya Antony, Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.

Department of pharmacy practice and PharmD Intern

Shiva Krishna, Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.

Department of pharmacy practice and PharmD 5th year

Jini James, Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.

Department of pharmacy practice and PharmD Intern

Akhilesh Kunoor, Department of Pulmonary Medicine, Amrita Institute of Medical Sciences, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.

Assistant Professor, Department of Pulmonary Medicine

Meenu Vijayan, Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Amrita Vishwa Vidyapeetham, Amrita University, India.

Assistant Professor, Department of Pharmacy Practice

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