CLOZAPINE-INDUCED DIABETIC KETOACIDOSIS: A CASE REPORT

Soumya Mary Alex; Vidya P Menon; Sabarish B; Umadevi P; Dipu T s

doi:10.22159/ajpcr.2018.v11i3.19140

Authors

Soumya Mary Alex Department of Clinical Pharmacy, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.
Vidya P Menon Department of Medicine/Medical Administration, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.
Sabarish B Department of Emergency Medicine and Critical Care, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.
Umadevi P Department of Clinical Pharmacy, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.
Dipu T s Department of Medicine/Medical Administration, Amrita Institute of Medical Sciences andResearch Centre, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i3.19140

Keywords:

Clozapine, Diabetic ketoacidosis, Type 2 diabetes, Antipsychoticajpcr2018v11i3

Abstract

Â The objective of this study was to report a case of a person with psychiatric illness treated with clozapine presented with diabetic ketoacidosis (DKA). A clinical monitoring was done on a 38-year-old Indian man affected by schizoaffective disorder, bipolar type presented with DKA after 3 months of clozapine therapy (250 mg/day). After treatment of DKA and discontinuation of clozapine, the patient improved symptomatically, his blood sugar levels normalized and insulin requirements also decreased. This report thus highlights that clinicians should be vigilant about the potential risk of new-onset diabetes and DKA in patients taking clozapine and utilize appropriate clinical and laboratory monitoring early in the course of treatment to prevent serious adverse effects.

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Author Biography

Soumya Mary Alex, Department of Clinical Pharmacy, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.

department of internal medicine

clinical pharmacist

B.PHARM,PHARM.D

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