DRUG UTILIZATION PATTERN OF ANTIDIABETIC DRUGS AMONG DIABETIC OUTPATIENTS IN A TERTIARY CARE HOSPITAL
Abstract
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Objective: The aim was to evaluate the drug utilization pattern of anti-diabetic drugs in diabetic outpatients and monitor the adverse drug reactions
(ADRs) associated with anti-diabetic therapy.
Methods: A prospective observational study was carried out in adult diabetic patients visiting the outpatient Departments of General Medicine and
Endocrinology of a tertiary care hospital. Demographic data, drug utilization pattern and ADRs due to anti-diabetic drugs were summarized.
Results: In the present study, 99 (50.3%) of the 197 diabetic patients were males. Majority of patients were in the age group of 51-60 years (39.6%) and
most of the patients (36.5%) had a diabetic history of <5 years. Metformin was the most commonly prescribed drug (68%), followed by sulfonylurea
class of drugs (49.7%). Nearly, 42% patients were using insulin preparations with 30.4% using biphasic isophane human insulin. Majority of the
patients (58.4%) were on multidrug therapy with two drug therapies being received by nearly 40%. Metformin was the most commonly prescribed
drug in monotherapy (18.8%) and glimepiride + metformin was the most common two drug therapy (13.2%). Co-morbid condition was found in 172
patients (87.3%) with hypertension (68.5%) being the most common co-morbid condition. 17 ADRs were observed with hypoglycemia being the most
common ADR reported.
Conclusions: Metformin was the most commonly used drug. The prescribing trend also appears to be moving towards combination therapy
particularly two drug therapies.
Keywords: Drug utilization, Anti-diabetic drug, Adverse drug reaction.
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References
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2012;35 Suppl 1:64-71.
IDF Diabetes Atlas. 6th ed. International Diabetes Federation, 2013. Available from: http://www.idf.org. [Last accessed on 2014 Nov 17].
King H, Aubert RE, Herman WH. Global burden of diabetes, 1995‑2025: prevalence, numerical estimates, and projections. Diabetes Care 1998;21(9):1414-31.
Unger J. Current strategies for evaluating, monitoring, and treating type 2 diabetes mellitus. Am J Med 2008;121(6 Suppl):S3-8.
Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 2005;65(3):385-411.
El-Kaissi S, Sherbeeni S. Pharmacological management of type 2 diabetes mellitus: An update. Curr Diabetes Rev 2011;7(6):392-405.
Lee D, Bergman U. Studies of drug utilization. In: Strom BL, editor. Pharmacoepidemiology. 4th ed. New York: John Wiley & Sons; 2005. p. 401.
Upadhyay DK, Palaian S, Ravi Shankar P, Mishra P, Sah AK. Prescribing pattern in diabetic outpatients in a tertiary care teaching hospital in Nepal. J Clin Diagn Res 2007;3:248-55.
Hassan Y, Mathialagan A, Awaisu A, Aziz NA, Yahaya R, Salhani A. Trend in the use of oral hypoglycemic agents in an outpatient pharmacy department of a tertiary hospital in Malaysia (2003-2006). Asian J Pharm Clin Res 2009;2:40-6.
Jimoh AO, Sabir AA, Chika A, Sani Z. Pattern of antidiabetic drugs use in a diabetic outpatient clinic of a tertiary health institution in Sokoto, North-western Nigeria. J Med Sci 2011;11:241-5.
John LJ, Arifulla M, Sreedharan J, Muttappallymyalil J, Das R, John J, et al. Age and gender-based utilisation pattern of antidiabetic drugs in Ajman, United Arab Emirates. Malay J Pharm Sci 2012;10:79-85.
Vengurlekar S, Shukla P, Patidar P, Bafna R, Jain S. Prescribing pattern of antidiabetic drugs in indore city hospital. Indian J Pharm Sci 2008;70(5):637-40.
Kannan, Arshad, Kumar S. A study on drug utilization of oral hypoglycemic agents in type-2 diabetic patients. Asian J Pharm Clin Res 2011;4:60-4.
Shamna M, Karthikeyan M. Prescription pattern of antidiabetic drugs in the outpatient departments of hospitals in Malappuram district, Kerala. J Basic Clin Physiol Pharmacol 2011;22(4):141-3.
Dave DJ, Dikshit RK, Gandhi AM. Utilization of some newer oral antidiabetic agents in a tertiary care hospital. Natl J Physiol Pharm Pharmacol 2012;2(2):146-51.
Kumar KS, Sreeramya G, Krishna KM, Nalini K, Kiranmai N, Vasavi P. Drug use pattern study of antidiabetics in type 2 diabetes mellitus at a tertiary care hospital in Tenali, Andhra Pradesh. Int J Inv Pharm Sci 2013;1:162-6.
Patel B, Oza B, Patel KP, Malhotra SD, Patel VJ. Pattern of antidiabetic drugs use in type 2 diabetic patients in a medicine outpatient clinic of a tertiary care teaching hospital. Int J Basic Clin Pharmacol 2013;2:485‑91.
Sivasankari V, Manivannan E, Priyadarsini SP. Drug utilization pattern of anti-diabetic drugs in a rural area of Tamil Nadu, South India - A prospective, observational study. Int J Pharm Bio Sci 2013;4:514-9.
Alam MS, Aqil M, Qadry SA, Kapur P, Pillai KK. Utilization pattern of oral hypoglycemic agents for diabetes mellitus type 2 patients attending out-patient department at a University hospital in New Delhi. Pharmacol Pharm 2014;5:636-45.
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