SERUM ANTIGLIADIN ANTIBODIES IN EGYPTIAN CHILDREN WITH AUTISM SPECTRUM DISORDER: RELATIONSHIP TO GASTROINTESTINAL SYMPTOMS, BEHAVIORAL AND SOCIAL COMMUNICATIONS

Inas R El-alameey; Hanaa H Ahmed; Ihab M Eid; Ghada El-dory; Manal Gameel

doi:10.22159/ajpcr.2018.v11i4.22723

Authors

Inas R El-alameey Child Health Department, National Research Centre, Egypt. http://orcid.org/0000-0002-0168-7663
Hanaa H Ahmed Hormones Department, National Research Centre, Egypt.
Ihab M Eid Medical Childhood Studies Department, Institute of Postgraduate Childhood Studies, Ain Shams University, Egypt.
Ghada El-dory Medical Childhood Studies Department, Institute of Postgraduate Childhood Studies, Ain Shams University, Egypt.
Manal Gameel Zahira Abdeen Hospital, Ministry of Health, Egypt.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i4.22723

Keywords:

Autism spectrum disorder, Antigliadin antibodies, Egyptian children, Gastrointestinal symptoms

Abstract

Â Objectives: Gastrointestinal symptoms are major characteristic in children with autism spectrum disorder (ASD), drawing attention to a potent association with gluten sensitivity. The goal of this study was to evaluate anti-gliadin antibodies serum levels in a group of Egyptian children with ASDs and to address the potential link to gastrointestinal (GI) symptoms, behavioral, and social communications.

Patients and Methods: This descriptive caseâ€“control study included 45 children diagnosed as ASD according to Diagnostic and Statistical Manual of Mental Disorders 5th Edition and a history of GI symptoms, compared with 45 apparently healthy children of matched age and sex. Serum anti-gliadin antibodies were measured using enzyme-linked immunosorbent assay kits.

Results: Serum levels of IgM, IgA, and IgG class antibodies to gliadin showed a significant increase compared to healthy controls (p<0.000). Multiple logistic regression analysis showed a significant association between the high serum levels of IgA and IgM class antibodies to gliadin in the studied patients and GI symptoms (p<0.05). A significant association was detected between the high serum levels of IgG antibodies to gliadin and the behavior symptoms (p<0.05).

Conclusions: The anti-gliadin antibody response and its association with GI symptoms indicated the involvement of abnormal immunologic intestinal permeability in affected children. Immune system of some autistic patients could be abnormally triggered by gluten assumption.

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Author Biography

Inas R El-alameey, Child Health Department, National Research Centre, Egypt.

Child health and nutrition, Child Health Department, National Research Centre, Giza, Egypt.

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