STUDY OF GLYCATED HEMOGLOBIN LEVELS IN POLYCYSTIC OVARY SYNDROME
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i5.22729Keywords:
Glycated hemoglobin, Polycystic ovarian syndrome, Pre-diabetes, Type 2 diabetes mellitusAbstract
 Objective: Polycystic ovarian syndrome (PCOS) is often accompanied by insulin resistance, obesity, and cardiometabolic risk factors. Androgen excess-PCOS recommends oral glucose tolerance test or glycated hemoglobin (HbA1C) to evaluate dysglycemia in PCOS subjects. We undertook this study to evaluate the prevalence of elevated HbA1C levels in PCOS women.
Methods: The study was carried out among 100 PCOS patients from SRM Hospital, 100 healthy individuals were included as controls. Fasting glucose, HbA1C, Insulin and Homeostasis Model Assessment-Insulin Resistance Index were estimated.
Results: Patients with polycystic ovary syndrome showed a significant increase in HbA1C levels (5.799±1.022; 4.96±0.625, p=0.001) when compared to the control group.
Conclusion: We found elevated HbA1C levels in PCOS women categorizing 26% as prediabetes and 28% as having type 2 diabetes mellitus.
Downloads
References
Adams JM, Taylor AE, Crowley WF Jr, Hall JE. Polycystic ovarian morphology with regular ovulatory cycles: Insights into the pathophysiology of polycystic ovarian syndrome. J Clin Endocrinol Metab 2004;89:4343-50.
Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H. Prevalence, phenotype and cardio metabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum Reprod 2012;27:3067-73.
Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M, et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002;48:436-72.
The Rotterdam ESHRE/ASRM-Sponsored Consensus Workshop Group Revised 2003. Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS). Hum Reprod 2004;19:41-7.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011;34 Suppl 1:S62-9.
Kim JJ, Choi YM, Cho YM, Jung HS, Chae SJ, Hwag KR. Prevalence of elevated glycated hemoglobin in women with polycystic ovary syndrome. Hum Reprod 2012;27:1439-44.
Celik C, Abali R, Bastu E, Tasdemir N, Tasdemir UG, Gul A. Assessment of impaired glucose tolerance prevalence with hemoglobin A(1)c and oral glucose tolerance test in 252 Turkish women with polycystic ovary syndrome: A prospective, controlled study. Hum Reprod 2013;28:1062- 8.
Velling Magnussen L, Mumm H, Andersen M, Glintborg D. Hemoglobin A1c as a tool for the diagnosis of Type 2 diabetes in 208 premenopausal women with polycystic ovary syndrome. Fertil Steril 2011;96:1275-80.
Legro RS. Diabetes prevalence and risk factors in polycystic ovary syndrome. Curr Opin Endocrinol Diabetes 2002;9:451-8.
Nehra J, Kaushal J, Singhal SR, Ghaulaut VS. Comparison of Myo-inositol versus Metformin on anthropometric parameters in polycystic ovarian syndrome in women. Int J Pharm Pharm Sci 2017;9:144-8.
Lerchbaum E, Schwetz V, Giuliani A, Obermayer-Pietsch B. Hypertriglyceridemic waist is associated with impaired glucose tolerance in polycystic ovary syndrome. Nutr Metab Cardiovasc Dis 2013;23:e15-6.
Haghighatpanah M, Thunga G, Khare S, Mallayasamy S. Correlation of glycosylated hemoglobin levels with fasting and postprandial glucose in South Indian Type 2 Diabetic patients. Int J Pharm Pharm Sci 2016;8:285-8.
Wild RA, Carmina E, Diamanti-Kandarakis E, Dokras A, Escobar-Morreale HF, Futterweit W, et al. Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: A consensus statement by the androgen excess and polycystic ovary syndrome (AE-PCOS) society. J Clin Endocrinol Metab 2010;95:2038-49.
Hurd WW, Abdel-Rahman MY, Ismail SA, Abdellah MA, Schmotzer CL, Sood A. Comparison of diabetes mellitus and insulin resistance screening methods for women with polycystic ovary syndrome. Fertil Steril 2011;96:1043-7.
Peters AL, Davidson MB, Schriger DL, Hasselblad V. A clinical approach for the diagnosis of diabetes mellitus: An analysis using glycosylated haemoglobin levels. Meta-analysis Research Group on the Diagnosis of Diabetes Using Glycated Haemoglobin Levels. JAMA 1996;276:1246-52.
Tomlinson J, Millward A, Stenhouse E, Pinkney J. Type 2 diabetes and cardiovascular disease in polycystic ovary syndrome: What are the risks and can they be reduced? Diabetes Med 2010;27:498-515.
Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 1999;84:165-9.
Norman RJ, Masters L, Milner CR, Wang JX, Davies MJ. Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome. Hum Reprod 2001;16:1995-8.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.