HIGH SENSITIVE C-REACTIVE PROTEIN AND ITS RELATIONSHIP WITH OTHER CARDIOVASCULAR RISK VARIABLES IN OBESE, OVERWEIGHT AND HEALTHY INDIVIDUALS

Gayathri B; Vinodhini Vm

doi:10.22159/ajpcr.2018.v11i8.26056

Authors

Gayathri B Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, SRM University, Kanchipuram - 603 203, Tamil Nadu, India.
Vinodhini Vm Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, SRM University, Kanchipuram - 603 203, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i8.26056

Keywords:

Cardiovascular disease, High sensitive C-reactive protein, Obesity

Abstract

Objective: More than 50% of the world's population is considered overweight and being overweight is associated with several comorbidities such as Type 2 diabetes mellitus, hypertension, cardiovascular diseases, dyslipidemia, respiratory diseases, osteoarthritis, and depression. Therefore, in this study, we have estimated the high sensitive C-reactive protein (hs-CRP) levels in obese, overweight, and normal body mass index (BMI) individuals and whether there was any relationship between hs-CRP and other risk factors of the cardiovascular system such as serum total cholesterol (TC) and other lipids.

Methods: A total of 150 participants, divided into three groups. Group I - 50 participants with normal BMI (18â€“22.99 kg/m2), Group II - 50 participants who were overweight (BMI = 23â€“24.99 kg/m2), and Group III - 50 who were obese (BMI â‰¥25 kg). We measured fasting plasma glucose, postprandial plasma glucose, serum TC, triacylglycerol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and hs-CRP.

Results: Obese individuals had increased hs-CRP compared with control (Group I) and overweight (Group II) groups. hs-CRP positively correlated with BMI and lipid profile.

Conclusion: Elevated hs-CRP was associated with cardiovascular risk factors in overweight and obese individuals. This high-risk group should be targeted for therapeutic lifestyle modifications to prevent further complications.

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Author Biographies

Gayathri B, Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, SRM University, Kanchipuram - 603 203, Tamil Nadu, India.

Assistant professor, Biochemistry

Vinodhini Vm, Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, SRM University, Kanchipuram - 603 203, Tamil Nadu, India.

Professor, Biochemistry

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