EFFECT OF SODIUM ALGINATE ON PREVENTION OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS IN RATS

Yulis Kartika; Hakim Bangun; Rosidah Rosidah

doi:10.22159/ajpcr.2018.v11i6.24768

Authors

Yulis Kartika Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Hakim Bangun Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Centre, University of Sumatera Utara, Medan, Indonesia.
Rosidah Rosidah Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i6.24768

Keywords:

Sodium alginate, Cholesterol levels, High-density lipoprotein, Low-density lipoprotein, Triglyceride, Foam cell

Abstract

Objective: The present study is to determine the effect of liquid of sodium alginate and powder on the prevention of raising cholesterol levels and atherosclerosis in rats (preventive effect).

Method: Experimental animals were divided into prevention groups. Preventive groups used were 24 normal rats and then divided into four groups, each group consisted of 6 animals: Group 1 (fed a regular diet), Group 2 (fed high cholesterol diet), Group 3 (fed high cholesterol diet and alginate liquid 2% diet), and Group 4 (fed high cholesterol and alginate powder). Rats are given with cholesterol food, alginate liquid, alginate powder a dose of 1 ml/100 g body weight once a day. Parameters measured were cholesterol level, low-density lipoprotein (LDL) levels, high-density lipoprotein (HDL) levels, triglyceride (TG) level, body weight every week, and histopathologically of the aorta for foam cells examined at the end of the experiment. Analysis of data was performed using one-way ANOVA.

Results: The lipid profiles in the preventive group showed alginate liquid and powder which have the effect of preventing increase total cholesterol, LDL, TG, number of foam cells, and decrease HDL. Diet using alginate powder better than alginate liquid, but the effect was not different significantly (p<0.05) so do the regular diet, but higher than given with high cholesterol diet significantly (p>0.05).

Conclusion: This study showed that the alginate liquid and alginate powder have an anti-hypercholesterolemia property which has been proved by preventing increase LDL, TG, and increased HDL levels.

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