PHYTOCHEMICAL SCREENING AND ANTI-INFLAMMATORY ACTIVITY OF FRACTIONS FROM SAMBUNG RAMBAT (MICANIA CORDATA) LEAF
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i8.26083Keywords:
Anti-inflammatory, Carrageenan, Micania cordata, Phytochemical, ScreeningAbstract
Objective: The present study is to evaluate the anti-inflammatory activity of various fractions from Sambung Rambat leaf (Micania cordata) using ethyl acetate, hexane, and water solvent as the solvent.
Methods: Investigation of phytochemical compound was using standard phytochemical screening method, while the anti-inflammatory was using the carrageenan-induced paw edema method in animal (rats) model.
Results: The phytochemical screening showed that the fractions of M. cordata had a lot of phytochemical compounds such as flavonoids, glycosides, steroids, triterpenoids, tannins, and saponins. Anti-inflammatory assessment showed that the strongest activity of anti-inflammatory produced by ethyl acetate fraction with 200 mg/kg BW dose.
Conclusion: This investigation could be concluded that ethyl acetate fraction of M. cordata might be a potential for the treatment of inflammatory.
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Leelaprakash G, Dass SM. In vitro anti-inflmmatory activity of methanol extract of Enicostemma axillare. Int J Drug Dev Res 2011;3:189-96.
Sadique J, Chandra T, Thenmozhi V, Elango V. The anti-inflammatory activity of Enicostemma littorale and Mullogo cerviana. Biochem Med Metab Biol 1987;37:167-76.
Paul RK, Jabbar A, Rashid MA. Antiulcer activity of Mikania cordata. Fitoterapia 2000;71:701-3.
Ahmed M, Rahman MT, Alimuzzaman M, Shilpi JA. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia 2001;72:979 21.
Bhattacharya S, Nag AK. Chemical constituents of the essential oil of Mikania cordata (Burm) B.L. Robinson root extract in rodent. J Essent Oil Res 1992;6:255-9.
Bishayee A, Chatterjee M. Anticarciogenic biological response of Mikania cordata: Reflections in hepatic biotransformation systems. Cancer Lett 1994;81:193-200.
Chowdhury NS, Alam MB, Zahan R, Sultana S, Nahar K, Haque ME. Antimicrobial and toxicity studies of different fractions of the aerial parts of the Mikania cordata. Int J Pharm Life Sci 2011;2:592-8.
Heyne K. Usefull Indonesia Plant. Jakarta: Yayasan Sarana Wana Jaya; 1987. p. 551-2.
Wiart C. Ethnopharmacology of Medicinal Plants: Asia and the Pacific. Totowa: Humana Press Inc.; 2006. p. 36.
Ditjen PO. Farmakope Indonesia. Vol. 4. Jakarta: Depkes RI; 1995. p. 896-8.
Basset J, Denney RC, Jeffrey GH, Mendham J. Buku Ajar Vogel: Kimia Analisis Kuantitatif Anorganik. 4th ed. Jakarta: EGC; 2018.
Sinaga SM, Iksen I, Haro G, Wardany S. Potency of chives (Allium schoenoprasum L.) leaves infuse as inhibitor calcium lithogenesis on urinary tract. Asian J Pharm Clin Res 2018;11:77-80.
Indonesia’s Department of Health. Materia Medika. Vol. 6. Jakarta: National Agency of Drug and Food Control; 1995. p. 297-307.
Farnsworth NR. Biologycal and phytochemical screening of plants. J Pharm Sci 1996;55:225-76.
Harbone JB. Phtyochemistry method. ITB 1987;2:6, 49.
Haro G, Sinaga SM, Iksen I, Nerdy N, Theerachetmongkol S. Protective effects of chives leaves (Allium schoenoprasum L.) infusion against ethylene glycol and ammonium chloride induced nephrolithiasis in rats. J Appl Pharm Sci 2017;7:222-5.
Winter CA, Risley EA, Nuss GW. Carrageenin induced oedema in hindpaws of the rats as an assay of anti-inflammatory drugs. Proc Soc Exp Biol Med 1962;111:544-7.
Yu D, Yuan Y, Jiang L, Tai Y, Yang X, Hu F, et al. Anti-inflammatory effects of essential oil in Echinacea purpurea L. Pak J Pharm Sci 2013;26:403-8.
Vinueza D, Lopez E, Acosta K, Abdo S. Assessment of anti-inflammaotry activity and cytotoxicity of freeze dried hydroalcoholic extract of Bidens andicola on isolated neutrophils. Asian J Pharm Clin Res 2017;10:160-3.
Ullah AH, Akter L, Zaman S, Juhara F, Tareq SM, Bhattacharjee R, et al. Anti-inflmammatory and analgesic activities of methanolic seed extract of Sterculia villosa Roxb. Asian J Pharm Clin Res 2015;8:247 51.
Laaboudi W, Ghanam J, Aissam H, Merzouki M, Benlemlih M. Anti-inflammatory and analgesic activities of olive tree extract. Int J Pharm Pharm Sci 2016;8:414-9.
Shaikh S, Joshi YM, Kadam V. Comparative study of anti-inflammatory activity if aqueous and methanolic extracts of Hibiscus cannabinus leaf (Malvaceae). Int J Pharm Pharm Sci 2016;8:64-8.
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