DICOMA ANOMALA SOND.: A REVIEW OF ITS BOTANY, ETHNOMEDICINE, PHYTOCHEMISTRY AND PHARMACOLOGY
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i6.25538Keywords:
Dicoma anomala, Ethnopharmacology, Primary health care, Traditional medicine, Tropical AfricaAbstract
Dicoma anomala is used as herbal medicine to treat and manage fever, coughs, colds, sore throats, abdominal pain, diarrhea, dysentery, constipation, intestinal worms, and sexually transmitted infections in tropical Africa. The aim of this study was to summarize the research that has been done on the ethnomedicinal uses, phytochemistry, and pharmacological properties of D. anomala in tropical Africa. The literature search for information on ethnomedicinal uses and pharmacological activities of D. anomala was undertaken using databases such as Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central, PubMed, and Springer link. Other relevant literature sources included books, book chapters, websites, theses, conference papers, and other scientific publications. This study showed that D. anomala is used as herbal medicine in 57.1% of the countries in tropical Africa where it is indigenous. The species is used to treat 66 and five human and animal diseases, respectively. Several classes of secondary metabolites including acetylenic compounds, diterpene, flavonoids, phenols, phytosterols, saponins, sesquiterpenes, tannins and triterpenes have been isolated from D. anomala. Different aqueous and organic extracts of D. anomala exhibited anthelmintic, anticancer, antihyperglycemic, anti-inflammatory, antimicrobial, antioxidant, antiplasmodial, and hepatoprotective activities. The documented information on the botany, ethnomedicinal uses, phytochemistry, and pharmacological properties of D. anomala provide baseline data required for further ethnopharmacological studies on the species.
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References
Dzerefos CM, Witkowski ET. Density and potential utilization of medicinal grassland plants from Abe Bailey Nature Reserve, South Africa. Biod Cons 2001;10:1875-96.
Van Wyk BE. A review of African medicinal and aromatic plants. In: Neffati M, Najjaa H, MáthéÃ, editors. Medicinal and Aromatic Plants of the World: Africa. Vol. 3. Dordrecht: Springer; 2017. p. 19-60.
Van Wyk BE. The potential of South African plants in the development of new medicinal products. S Afr J Bot 2011;77:812-29.
Jacot-Guillarmod AJ. A medicine chest from the veld: Basotho materia medica. Veld Fl 1981;5:113-5.
Moteetee A, Van Wyk BE. The medical ethnobotany of Lesotho: A review. Bothalia 2011;41:209-28.
Gelfand M, Mavi S, Drummond RB, Ndemera B. The traditional medicine practitioner in Zimbabwe: His principles of practice and pharmacopoeia. Gweru: Mambo Press; 1985.
Van Wyk BE, Gericke N. People’s plants: A guide to useful plants of southern Africa. Pretoria: Briza Publications; 2007.
Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of southern and eastern Africa. Edinburgh: E and S Livingstone Ltd; 1962.
Morris B. Chewa medical botany: A study of herbalism in southern Malawi. Hamburg: Lit Verlag; 1996.
Meke GS, Mumba RF, Bwanali RJ, Williams VL. The trade and marketing of traditional medicines in southern and central Malawi. Int J Sustain Dev World Ecol 2017;24:73-87.
Williams VL, Balkwill K, Witkowski ET. A lexicon of plants traded in the Witwatersrand Umuthi shops. Bothalia 2001;31:71-98.
Monakisi CM. Knowledge and use of Traditional Medicinal Plants by the Setswana Speaking Community of Kimberley, Northern Cape of South Africa. MSc Dissertation. Cape Town: Stellenbosch University; 2007.
Talukdar S. Lesotho. In: Golding JS, editor. Southern African Plant Red Data Lists. Pretoria: Southern African Botanical Diversity Network Report No. 14, SABONET; 2002. p. 21-30.
Wild H. The compositae of the Flora Zambesiaca area. 3. Mutisieae. Kirkia 1972;8:189-92.
Pope GV. Notes on Dicoma Cass. (Compositae). Kew Bull 1991;46:699 709.
Pope GV. Compositae. Flora Zambes 1992;6:37-8.
Onderstall J. Wild flower guide: Mpumalanga and northern Province. Nelspruit: Fishwicks the Printers; 1996.
Burrows JE, Willis CK. Plants of the Nyika Plateau: An Account of the Vegetation of the Nyika National Parks of Malawi and Zambia. Pretoria: Southern African Botanical Diversity Network Report No. 31 SABONET; 2005.
Setshogo MP. Preliminary Checklist of the Plants of Botswana. Pretoria: Southern African Botanical Diversity Network Report No. 37 SABONET; 2005.
Netnou N, Herman PP. Dicoma. In: Germishuizen G, Meyer NL, Steenkamp Y, Keith MA, editors. Plants of Southern Africa: An Annotated Checklist. Pretoria: Strelitzia 14: National Botanical Institute; 2006. p. 209-10.
Kirby G. Wild flowers of southeast Botswana. Cape Town: Struik Nature; 2013.
Mnegwane J, Koekemoer M. Dicoma anomala Sond. Pretoria: South African National Biodiversity Institute; 2007. Available from: http:// www.plantzafrica.com/plantcd/dicomanom.htm. [Last accessed on 2017 Jul 25].
Ortiz S, Rodriguez-Oubiña J. A new taxonomic interpretation of the Dicoma anomalacomplex (Mutisieae, Asteraceae). Nordic J Bot 1996;16:583-4.
Gelfand M. Medicine and Magic of the Mashona. Cape Town: Juta; 1956.
Mavi S. Medicinal Plants and their Uses in Zimbabwe. In: Norman H, Snyman I, Cohen M, editors. Indigenous Knowledge and Its Uses in Southern Africa. Cape Town: HSRC Press; 1996. p. 67-74.
Marekerah L. A Survey on the Biological Activities of Selected Plants used to Manage Diarrhoea and Cancer in Vumba, Zimbabwe. BSc Honours Dissertation. Gweru: Midlands State University; 2015.
Mwafongo E, Nordal I, Magombo Z, Stedje B. Ethnobotanical study of hyacinthaceae and non-hyacinthaceous geophytes in selected districts of Malawi. Ethnobot Res Appl 2010;8:75-93.
Mabona U, Viljoen A, Shikanga E, Marston A, Van Vuuren S. Antimicrobial activity of southern African medicinal plants with dermatological relevance: From an ethnopharmacological screening approach, to combination studies and the isolation of a bioactive compound. J Ethnopharmacol 2013;148:45-55.
Maroyi A. Elephantorrhiza elephantina: Traditional uses,phytochemistry and pharmacology of an important medicinal plant species in southern Africa. Evid Based Complement Altern Med 2017;2017:6856154.
Madzinga M, Kritzinger Q, Lall N. Medicinal plants used in the treatment of superficial skin infections: From traditional medicine to herbal soap formulations. In: Lall N, editor. Medicinal Plants for Holistic Health and Well-Being. London: Academic Press; 2017. p. 256-76.
Hutchings A, Scott AH, Lewis G, Cunningham AB. Zulu Medicinal Plants: An Inventory. Pietermaritzburg: University of Natal Press; 1996.
Maema LP, Mahlo SM, Potgieter MJ. Ethnomedicinal uses of indigenous plant species in Mogalakwena municipality of Waterberg District, Limpopo province South Africa. Int J Tradit Complem Med 2016;1:28-44.
Watt JM, Brandwijk MG. Suto (Basuto) medicines. Bantu Stud 1927;3:73-100.
Roberts M. Indigenous Healing Plants. Johannesburg: Southern Book Publishers; 1990.
Von Koenen E. Medicinal, Poisonous and Edible Plants in Namibia. Windhoek: Klaus Hess; 2001.
Semenya SS, Potgieter MJ, Tshisikhawe MP. Use, conservation and present availability status of ethno medicinal plants of Matebele village in the Limpopo province, South Africa. Afr J Biotechnol 2013;12:2392 405.
Kose LS, Moteetee A, Van Vuuren S. Ethnobotanical survey of medicinal plants used in the Maseru district of Lesotho. J Ethnopharmacol 2015;170:184-200.
Moteetee A, Kose LS. Medicinal plants used in Lesotho for treatment of reproductive and post reproductive problems. J Ethnopharmacol 2016;194:827-49.
Amusan OO, Sukati NA, Shongwe MS. Some phytomedicines from Shiselweni region of Swaziland. J Nat Remedies 2005;5:19-25.
Jacot-Guillarmod A. Flora of Lesotho. Lehre: J Cramer; 1971.
Mugomeri E, Chatanga P, Raditladi T, Makara M, Tarirai C. Ethnobotanical study and conservation status of local medicinal plants: Towards a repository and monograph of herbal medicines inLesotho. Afr J Tradit Complement Altern Med 2016;13:143-56.
Gerstner J. A preliminary checklist of Zulu names of plants with short notes. Bantu Stud 1939;13:49-64.
Hedberg IF, Staugard F. Traditional Medicinal Plants: Traditional Medicine in Botswana. Gaborone: Ipelegeng Publishers; 1989.
Satyajit T, Andrew W, Matsabisa MG. Dicoma anomala Sond [Asteraceae]: Apossible resource of future antimalarial agents. Res Rev Res J Biol 2017;5:19-20.
Balogun FO, Tshabalala NT, Ashafa AO. Antidiabetic medicinal plants used by the Basotho tribe of eastern Free State: A review. J Diabetes Res 2016;2016:1-13.
Chinemana F, Drummond RB, Mavi S, De Zoysa I. Indigenous plant remedies in Zimbabwe. J Ethnopharmacol 1985;14:159-72.
Shale TL, Stirk WA, Van Staden J. Screening of medicinal plants used in Lesotho for anti-bacterial and anti-inflammatory activity. J Ethnopharmacol 1999;67:347-54.
Setshogo MP, Mbereki CM. Floristic diversity and use of medicinal plants sold by street vendors in Gaborone, Botswana. Afr J Plant Sci Biotech 2011;5:69-74.
Semenya SS, Maroyi A. Medicinal plants used by the Bapedi traditional healers to treat diarrhoea in the Limpopo province, South Africa. J Ethnopharmacol 2012;144:395-401.
Bally PR. Native medicinal and poisonous plants of East Africa. Bull Miscell Inform 1937;1:10-26.
Varga CA, Veale DJ. Isihlambezo: Utilization patterns and potential health effects of pregnancy related traditional herbal medicine. Soc Sci Med 1997;44:911-24.
Panganai T, Shumba P. The African Pitocin- A midwife’s Dilemma: The perception of women on the use of herbs in pregnancy and labour in Zimbabwe, Gweru. Pan Afr Medical J 2016;25:9.
Steenkamp V. Traditional herbal remedies used by South African women for gynaecological complaints. J Ethnopharmacol 2003;86:97 108.
Amusan OO, Dlamini PS, Msonthi JD, Makhubu LP. Some herbal remedies from Manzini region of Swaziland. J Ethnopharmacol 2002;79:109-12.
Biegel HM. Rhodesian Wild Flowers. Harare: Thomas Meikle Series No. 4. Zimbabwe: Trustees of the National Museums and Monuments of Rhodesia; 1979.
Balogun FO, Ashafa AO. Aqueous root extracts of Dicoma anomala (Sond.) ameliorates against isoproterenol-induced myocardial infarction inWistar rats. Trop J Pharm Res 2016;15:1651-7.
Moteetee A, Kose LS. A review of medicinal plants used by the Basotho for treatment of skin disorders: their phytochemical, antimicrobial, and anti-inflammatory potential. Afr J Tradit Complement Altern Med 2017;14:121-37.
Ndamba J, Nyazema N, Makaza N, Anderson C, Kaondera KC. Traditional herbal remedies used for the treatment of urinary schistosomiasis in Zimbabwe. J Ethnopharmacol 1994;42:125-32.
Kokwaro JO. Medicinal Plants of East Africa. Nairobi: East African Literature Bureau; 1976.
Chigora P, Masocha R, Mutenheri F. The role of indigenous medicinal knowledge (IMK) in the treatment of ailments in rural Zimbabwe: The case of Mutirikwi communal lands. J Sustain Dev Afr 2007;9:26-43.
Olivier DK, Van Wyk BE. Bitterness values for traditional tonic plants of southern Africa. J Ethnopharmacol 2013;147:676-9.
Olivier DK. The Ethnobotany and Chemistry of South African Tonic Plants. PhD Thesis. Johannesburg: University of Johannesburg; 2012.
Bohlmann F, Le Van N. New germacronolides from Dicoma anomala. Phytochem 1978;17:570-1.
Bohlmann F, Singh P, Jakupovic J. New germacronolides and other sesquitcrpene lactones from Dicoma species. Phytochem 1982;21:2029 33.
Zdero C, Bohlmann F. Sesquiterpene lactones from Dicoma species. Phytochem 1990;29:183-7.
Van der Merwe MM. Bioactive Sesquiterpenoids from Dicoma anomala subsp. gerradii. MSc Dissertation. Pietermaritzburg: University of KwaZulu-Natal; 2008.
Rademeyer M, Van Heerden FR, Van der Merwe MM. Dehydrobrachylaenolide: aneudesmane-type sesquiterpene lactone. Acta Cryst 2009;E65:196.
Becker JV, Van der Merwe MM, Van Brummelen AC, Pillay P, Crampton BG, Mmutlane EM, et al. In vitro anti-plasmodial activity of Dicoma anomala subsp. Gerrardii (Asteraceae): Identification of its main active constituent, structure-activity relationship studies and gene expression profiling. Malaria J 2011;10:295.
Bremer K. Asteraceae, Cladistics and Classification. Portland: Timber Press; 1994.
Mukanganyama S, Bezabih M, Robert M, Ngadjui BT, Kapche GF, Ngandeu F, et al. The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1. J Enzyme Inhib Med Chem 2011;26:460-7.
Munodawafa T, Chagonda LS, Moyo SR. Antimicrobial and phytochemical screening of some Zimbabwean medicinal plants. J Biol Active Prod Nat 2013;3:323-30.
Mølgaard P, Nielsen SB, Rasmussen DE, Drummond RB, Makaza N,Andreassen J. Anthelmintic screening of Zimbabwean plants traditionally used against schistosomiasis. J Ethnopharmacol 2001;74:257-64.
Balogun FO, Ashafa AOT. Aqueous roots extract of Dicomaanomala (Sond.) extenuates postprandial hyperglycaemia in vitro and its modulation against on the activities of carbohydrate-metabolizing enzymes in streptozotocin-induced diabetic Wistar Rats. S Afr J Bot 2017;112:102-111.
Balogun FO, Ashafa AO. Cytotoxic, kinetics of inhibition of carbohydrate-hydrolysing enzymes and oxidative stress mitigation by flavonoids roots extract of Dicoma anomala (Sond.). Asian Pac J Trop Med 2018;11:24-31.
Vlietinck AJ, Van Hoof L, Totte J, Lasure A, Van den Berghe D, Rwangabo PC, et al. Screening of hundred Rwandese medicinal plants for antimicrobial and antiviral properties. J Ethnopharrnacol 1995; 46:31-47.
Steenkamp V, Mathivha E, Gouws MC, Van Rensburg CE. Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa. J Ethnopharmacol 2004;95:353-7.
Mabona U. Antimicrobial Activity of Southern African Medicinal Plants with Dermatological Relevance. MSc Dissertation. Johannesburg: Witwatersrand University; 2013.
Balogun F, Ashafa A. Comparative study on the antioxidant activity of Dicoma anomala and Gazania krebsiana used in Basotho traditional medicine. S Afr J Bot 2015;98:170.
Balogun F, Ashafa A. Antioxidant and hepatoprotective activities of Dicoma anomala Sond. aqueous root extract against carbon tetrachloride-induced liver damage in Wistar rats. J Trad Chinese Med 2016;36:504-13.
Tselanyane ML. The Isolation, Characterization and Antiplasmodial Activity of Two Novel Dimeric Sesquiterpenes from Dicoma anomala. PhD Thesis. Cape Town: University of Cape Town; 2006.
Asita AO, Heisi DH, Tjale T. Modulation of mutagen-induced genotoxicity by two Lesotho medicinal plants in Allium cepa L. Environ Nat Res 2015;5:37-55.
Munodawafa T, Moyo S, Chipurura B, Chagonda L. Brine shrimp lethality bioassay of some selected Zimbabwean traditional medicinal plants. Int J Phytopharmacol 2017;8:8-12.
Sawant DV, Desai MM, Patil RS, Pawar SH. Evolution of nanotech assisted PCR diagnosis of Mycobacterium tuberculosis and its assessment with conventional methods. Int J Pharm Pharm Sci 2018;10:133-7.
Illahi RK, Pramestutie HR, Desyana MS. The use of assistive counselling tool lung TB care†to increase patient’s knowledge level (a study in tuberculosis patients at Malang’s primary health care centers). Int J Pharm Pharm Sci 2018;10:174-7.
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