HEAVY METAL ANALYSIS OF BLEPHARIS MADERASPATENSIS (L.) HEYNE EX ROTH

Authors

  • Vijayalakshmi S Department of Biochemistry, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
  • Kripa Kg Department of Biochemistry, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i10.26418

Keywords:

Blepharis maderaspatensis, Herbal drug, Heavy metal toxicity, Heavy metal analysis, Inductively coupled plasma optical emission spectrometry

Abstract

Objective: The objective of the study was to execute systematic heavy metal assessment of the plant to ensure its safe usage in herbal medicine or as nutraceuticals. Blepharis maderaspatensis (L.)Heyne ex Roth commonly called as Nethiramooli in Tamil is a widely distributed medicinal herb with a long history of traditional usage in the treatment of many ailments.

Method: The plant material was collected from Thanjavur, Tamil Nadu, India, duly authenticated and heavy metal content investigated by inductively coupled plasma optical emission spectrometry.

Results: Results indicated that the toxic metal, mercury was not detectable even in traces; other metals such as cadmium, chromium, molybdenum, manganese, nickel, and lead were found at very low quantities while trace elements such as iron, zinc, copper, and cobalt in fairly significant concentrations.

Conclusions: These results thus substantiate the safe usage of this plant and may be used to set new standards for prescribing the dosage of the herbal drugs prepared from it, ensuring a better understanding of the risks associated with its usage.

Downloads

Download data is not yet available.

Author Biographies

Vijayalakshmi S, Department of Biochemistry, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

ASSISTANT PROFESSOR,

DEPARTMENT OF HOTEL AND CATERING MANAGEMENT,

VISTAS, PALLAVARAM, CHENNAI, INDIA

Kripa Kg, Department of Biochemistry, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

PROFESSOR,

DEPARTMENT OF BIOCHEMISTRY

References

Kaur L, Joseph L, George m. Phytochemical analysis of leaf extract of Aesculus Indica. Int J Pharm Pharm Sci 2011;3:232-4.

Singh R, Gautam N, Mishra A, Gupta R. Heavy metals and living systems: An overview. Indian J Pharmacol 2011;43:246-53.

World Health Organization. WHO Guidelines for Assessing Quality of Herbal Medicines with Reference to Contaminants and Residues. Geneva: World Health Organization; 2007. p. 1-53.

Singh MR. Impurities-Heavy Metals. Spain: IR Prespective; 2007.

Brown SE, Welton WC. Heavy Metal Pollution. New York: Nova Science Publishers; 2008.

Chibuike GU, Obiora SC. Heavy metal polluted soils: Effect on plants and bioremediation methods. Appl Environ Soil Sci 2014;2014:1-12.

Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. EXS 2012;101:133-64.doi:10.1007/978- 3-7643-8340-4-6.

Theron AJ, Tintinger GR, Anderson R. Harmful interactions of non-essential heavy metals with cells of the innate immune system. J Clinic Toxicol 2012;3:1-10.

Chowdhury BA, Chandra RK. Biological and health implications of toxic heavy metal and essential trace element interactions. Prog Food Nutr Sci 1987;11:55-113.

Boyer T. Ayurveda Medicine and Supplement Hidden Dangers: Arsenic, Lead and Mercury.Available from: https://www.Emaxhealth. com/. [Last accessed on 2012 May 2].

Ganesan S, Ramar PN, Banumathi N. Ethnomedicinal survey of Alagarkoil hills (reserved forest) Tamil Nadu, India. Electron J Indian Med 2007;1:11-9.

Blepharis maderaspatensis, Dudhiya choti, Kooravaalchedi. Available from: http://www.medplants.blogspot.in/2015/04/blepharis-maderaspatensis-dudhiya-choti.html. [Last accessed on 2015 April 11].

Suriyavathana M, Indupriya S, Subha P. Preliminary phytochemical screening and antioxidant potential of Blepharis maderaspatensis (L.) B. Heyne ex Roth leaf. World J Pharm Pharm Sci 2014;3:658-68.

Devarajan ND, Ramalingam S, Subramaniam SM. Gas chromatography mass spectroscopy chromatogram and antimicrobial activity of leaf extracts of Blepharis maderaspatensis and Maesa indica. J Herbs Spices Med Plants 2014;21:267-82.

Vijayalakshmi S, Kripa KG. Therapeutic uses of plants of genus Blepharis-a systematic review. Int J Pharm Bio Sci 2016;7:236-43.

Koldabadi SG, Ruchi V, Bhaskar KV, Lalit K. Heavy metals in environment, living systems and herbal preparation: An overview. Int Resb J Pharm 2012;3:128-30.

Narzary H, Basumatary S. Determination of mineral composition of some wild edible plants consumed by Bodos of Assam, North-East India. J Chem Pharm Res 2017;9:60-4. Available from: http://www. jocpr.com. [Last accessed on 2016 Feb 11].

Kripa KG, Sangeetha R, Chamundeeswari D. Pharmacognostical and physicochemical evaluation of the plant Leucas aspera. Asian J Pharm Clin Res 2016;9:263-68.

Mallya R, Bhitre MJ. Pharmacognostic standardisation and chromatographic fingerprinting of leaves and fruits of Zanthoxylum Rhetsa. Int J Pharm Pharm Sci 2018;10:101-4.

Zaprjanova PS, Angelova GL, Bekjarov KI, Ivanov AA, ICP. Determination of heavy metal content in tobacco, Bulgarian. J Agric Sci 2006;12:537-51.

Reichert U, Sehat N. Metal Residue: How Much is Too Much? To Comply with Evolving Guidelines, Drug Makers will Need Analytical and Regulatory Support. Pharmaceutical manufacturing; 2013. Available from: http://www.pharmamanufacturing.com. [Last accessed on 2017 Jun 1].

Stanojkovic-sebic A, Pivic R, Josic D, Dinic Z, Stanojkovi A. Heavy metals content in selected medicinal plants commonly used as components for herbal formulations. J Agric Sci 2015;21:317-25.

Emst E. Toxic heavy metals and undeclared drugs in Asian herbal medicines. Trends Pharmacol Sci 2002;23:136-9.

Shaban NS, Abdou KA, Hassan NE. Impact of toxic heavy metals and pesticide residues in herbal products. J Basic Appl Sci 2016;5:1-5.

The American Herbal Products Association. Heavy Metals: Analysis and Limits in Herbal Dietary Supplements. The American Herbal Products Association; 2009. p. 12-3. Available from: http://www. naturalhealthresearch.org/. [Last accessed on 2017 May 15].

World Health Organization. Childhood Lead Poisoning. World Health Organization; 2010. p. 11-54. Avilable from: http://www.who.int/. [Last accessed on 2017 Jan 29].

Mercury, Vermont Legislative Research Shop, The University of Vermont. Available from: http://www.uvm.edu/~vlrs/doc/mercury.htm. [Last accessed on 2017 Jan 20].

Saha JC, Dikshit AK, Bandyopadhyay M, Saha KC. A Review of Arsenic Poisoning and its Effects on Human Health; 2014. p. 1-38. Available from: https://www.epa.gov/sites/production/files/2014-03/ documents/. [Last accessed on 2017 Jan 17].

Saper RB, Kales SN, Paquin J, Burns MJ, Eisenberg DM, Davis RB, et al. Heavy metal content of ayurvedic herbal medicine products. JAMA 2004;292:2868-73.

Dghaim R, Al Khatib S, Rasool H, Khan A. Determination of heavy metal concentration in traditional herbs commonly consumed in the United Arab Emirates. J Environ Public Health 2015;2015:1-6.

Published

07-10-2018

How to Cite

S, V., and K. Kg. “HEAVY METAL ANALYSIS OF BLEPHARIS MADERASPATENSIS (L.) HEYNE EX ROTH”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 10, Oct. 2018, pp. 251-3, doi:10.22159/ajpcr.2018.v11i10.26418.

Issue

Section

Original Article(s)