CURRENT DEVELOPMENTS ON ANTI-INFLAMMATORY NATURAL MEDICINES
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i8.26523Keywords:
Single natural products, Plant products, Non-plant products, Anti-inflammatory activity, Molecular pharmacologyAbstract
New anti-inflammatory substances are still vitally necessary due to intolerable side effects of the marketed anti-inflammatory drugs; however, the search for the novel entity against inflammation is challenging because of the complexity of the inflammatory process and its role in host defense to infections. Nature is the source of remedies for the mankind. Among the different biological activities of natural products that have been published till date, anti-inflammation is one of the most reported effects. In this review, we have discussed the current (2009–2018) information of some single natural products (quercetin, parthenolide, resveratrol, curcumin, cucurbitacin, capsicin, 1,8-cineole, bromelain, boswellic acid, lyprinol, and coumarin), plant products (garlic, ginger, papaya, blueberry, aloe, broccoli, olive, and rosemary), and non-plant products (marine sponges, mushrooms, and honey) having anti-inflammatory effects. Current information is mainly based on the molecular mechanisms of the above-mentioned products.
Downloads
References
Latruffe M. Natural products and inflammation. Molecules 2017;22:1-3.
Matthew F, Cecilia L, Jai B, Henry TL. Curcumin: An age-old anti-inflammatory and anti-neoplastic agent. J Trad Comp Med 2017;7:339-46.
Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets 2011;12:332-47.
Matsushima K, Terashima Y, Toda E, Shand F, Ueha S. Chemokines in inflammatory and immune diseases. Inflamm Regen 2011;31:11-22.
Lawrence T, Fong C. The resolution of inflammation: Anti-inflammatory roles for NF-kappa B. Int J Biochem Cell Biol 2010;42:519-23.
Bosma-den Boer MM, van Wetten ML, Pruimboom L. Chronic inflammatory diseases are stimulated by current lifestyle: How diet, stress levels and medication prevent our body from recovering. Nutr Metab 2012;9:32.
He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: How are they linked? Molecules 2015;20:9183-213.
Mandal SK, Ray SM. Synthesis and biological evaluation of (5, 6-dialkoxy-3-oxo-2,3dihydro 1H-inden-1-yl)acetic acid esters as anti- inflammatory agents with much reduced gastrointestinal ulcerogenic potential. Indo Am J Pharm Res 2014;4:3796-807.
Lanas A. A review of the gastrointestinal safety data-a gastroenterologist’s perspective. Rheumatology 2010;49:ii3-10.
Vishwanathan B, Gurupadayya BM, Sairam KV, Inturi BK. Design, synthesis, in vitro antioxidant and in vivo anti-inflammatory activities of novel oxadiazole derivatives. Int J Pharm Pharm Sci 2014;6:514-20.
Mandal SK, Ray SM. Synthesis and biological evaluation of (6-chloro-3-oxo-2,3- dihydro 1H-inden-1-yl)acetic acid esters as anti-inflammatory agents devoid of ulcerogenic potential at the tested dose level. Indo Am J Pharm Res 2014;4:343-50.
Kaidama WM, Gacche RN. Anti-inflammatory activity of quercetin in acute and chronic phases of inflammation in guinea pigs. Am J Phy Clin Ther 2015;3:129-36.
Lee KM, Hwang MK, Lee DE, Lee KW, Lee HJ. Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells. J Agric Food Chem 2010;58:5815-20.
Yang D, Liu X, Liu M, Chi H, Liu J, Han H. Protective effects of quercetin and taraxasterol against H2O2-induced human umbilical vein endothelial cell injury in vitro. Exp Ther Med 2015;10:1253-60.
Boots AW, Drent M, de Boer VC, Bast A, Haenen GR. Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clin Nutr 2011;30:506-12.
Karuppagounder V, Arumugam S, Thandavarayan RA, Sreedhar R, Giridharan VV, Watanabe K. Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis. Drug Discov Today 2016;21:632-9.
Xhang X, Fan C, Xiao Y, Mao X. Anti-inflammatory and antiosteoclastogenic activities of parthenolide on human periodontal ligament cells in vitro. Evid Based Complement Altern Med 2014;2014:1-11.
Sur R, Martin K, Liebel F, Lyte P, Shapiro S, Southali M. Anti-inflammatory activity of parthenolide-depleted feverfew. Inflammopharmacology 2009;17:42-9.
Campagna M, Rivas C. Antiviral activity of resveratrol. Biochem Soc Trans 2010;38:50-3.
Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I. Regulation of SIRT1 in cellular functions: Role of polyphenols. Arch Biochem Biophys 2010;501:79-90.
Nakata R, Takahashi S, Inoue H. Recent advances in the study on resveratrol. Biol Pharm Bull 2012;35:273-9.
Schmitt CA, Dirsch VM. Modulation of endothelial nitric oxide by plant-derived products. Nitric Oxide 2009;21:77-91.
Wahab A, Gao K, Jia C, Zhang F, Tian G, Murtaza G, et al. Significance of resveratrol in clinical management of chronic diseases. Molecules 2017;22:1329.
Berman AY, Motechin RA, Wiesenfeld MY, Holz MK. The therapeutic potential of resveratrol: A review of clinical trials. NPJ Precis Oncol 2017;1:1-17.
Abdelwahab SI, Hassan LE, Sirat HM, Yagi SM, Koko WS, Mohan S, et al. Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus variety citroides. Fitoterapia 2011;82:1190-7.
Wang Y, Zhao GX, Xu LH, Liu KP, Pan H, He J, et al. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviours of mouse lymphocytes. PLoS One 2014;9:e89751.
O’Neill J, Brock C, Olesen AE, Andresen T, Nilsson M, Dickenson AH. Unravelling the mystery of capsaicin: A tool to understand and treat pain. Pharmacol Rev 2012;64:939-71.
Haanpaa M, Treede RD. Capsaicin for neuropathic pain: Linking traditional medicine and molecular biology. Eur Neurol 2012;68:264-75.
De Silva V, El-Metwally A, Ernst E, Lewith G, Macfarlane GJ. Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: A systematic review. Rheumatology 2011;50:911-20.
Bhowal M, Gopal M. Eucalyptol: Safety and pharmacological profile. RGUHS J Pharm Sci 2015;5:126-41.
Juergens UR. Anti-inflammatory properties of the monoterpene 1.8-cineole: Current evidence for co-medication in inflammatory airway diseases. Drug Res 2014;64:638-46.
Juergens LJ, Racké K, Tuleta I, Stoeber M, Juergens UR. Anti-inflammatory effects of 1, 8-cineole (eucalyptol) improve glucocorticoid effects in vitro: A novel approach of steroid-sparing add-on therapy for COPD and asthma? Synergy 2017;5:1-8.
Greiner JF, Müller J, Zeuner MT, Hauser S, Seidel T, Klenke C, et al. 1, 8-Cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity. Biochim Biophys Acta 2013;1833:2866-78.
Tap FM, Majid FA, Ismail HF, Wong TS, Shameli K, Miyake M, et al. In silico and in vitro study of the bromelain-phytochemical complex inhibition of phospholipase A2 (PLA2). Molecules 2018;23:1-13.
Habashi SA, Sabouni F, Moghimi A, Majd SA. Modulation of lipopolysaccharidestimulated nuclear factor kappa B mediated iNOS/ NO productionby bromelain in rat primary microglial cells. Iran Biomed J 2016;20:33-40.
Ammon HP. Modulation of the immune system by Boswellia serrata extractsand boswellic acids. Phytomedicine 2010;17:862-7.
Sididiqui MZ. Boswellia serrata, a potential anti inflammatory agent, a review. Ind J Pharm Sci 2011;73:261-6.
Chaturvedi AK, Mishra N, Siddiqui HH, Mishra V. Semisynthetic hybrids of boswellic acids: A novel class of potential anti-inflammatory and anti-arthritic agents. Med Chem Res 2015;24:2799-812.
Calzado YR, Cuevas VM, Guerra YP, Yera AO, Despaine SJ, Ferreiro RM. Anti-edema effects of D-002 and lyprinol on the carrageenan-induced pleurisy in rats. Int J Pharm Sci Rev Res 2013;23:24-8.
Doggrell SA. Lyprinol-is it a useful anti-inflammatory agent? Evid Based Complement Altern Med 2011;2011. Article ID: 307121:1-7.
Yao R, Fu Y, Li S, Tu L, Zeng X, Kuang N. Regulatory effect of daphnetin, a coumarin extracted from Daphne odora, on the balance of Treg and Th17 in collagen-induced arthritis. Eur J Pharmacol 2011;670:286-94.
Yu W, Wang H, Ying H, Yu Y, Chen D, Ge W, et al. Daphnetin attenuates microglial activation and proinflammatory factor production via multiple signaling pathways. Int Immunopharmacol 2014;21:1-9.
Gholami O, Shamsara J. Comparison of the cytotoxic effects of umbelliprenin and auraptene. Int J Pharm Pharm Sci 2015;8:1-4.
Azelmat J, Fiorito S, Taddeo VA, Genovese S, Epifano F, Grenier D. Synthesis and evaluation of antibacterial and anti-inflammatory properties of naturally occurring coumarins. Phytochem Lett 2015;13:399-405.
Arreola R, Quintero-Fabián S, López-Roa RI, Flores-Gutiérrez EO, Reyes-Grajed JP, Carrera-Quintanar L, et al. Immunomodulation and anti-inflammatory effects of garlic compounds. J Immunol Res 2015;2015. Article ID 401630:1-13.
Schäfer G, Kaschula CH. The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention. Anti Cancer Agents Med Chem 2014;14:233-40.
Mashhadi NS, Ghiavsand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: Review of current evidence. Int J Prev Med 2013;4:S36-42.
Shimoda H, Shan SJ, Tanaka J, Seki A, Seo JW, Kasajima N, et al. Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. J Med Food 2010;13:156-62.
Milind P, Gurditta. Basketful benefits of Papaya. Int Res J Pharm 2011;2:6-12.
Amri E, Mamboya F. Papain, a plant enzyme of biological importance: A review. Am J Biochem Biotech 2012;8:99-104.
Pandey S, Cabot PJ, Shaw PN, Hewavitharana AK. Anti-inflammatory and immune-modulatory properties of Carica papaya. J Immunotoxicol 2016;13:590-602.
Bertrand S, Donatella F, Rita C, Carla M, Giancarlo F, Vittorio C. Anti-oxidant and anti-inflammatory activities of extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva medicinal plants collected in Cameroon. PLoS One 2014;9:e103999.
Ebenezer PJ, Wilson CB, Wilson LD, Nair AR, Francis J. The anti-inflammatory effects of blueberries in an animal model of post-traumatic stress disorder (PTSD). PLoS One 2016;11:e0160923.
Johnson MH, de Meija EG, Fan J, Lila MA, Yousef GG. Anthocyanins and proanthocyanidins from blueberry–blackberry fermented beverages inhibit markers of inflammation in macrophages and carbohydrate-utilizing enzymes in vitro. Mol Nutr Food Res 2013;57:1182-97.
Huang WY, Liu YM, Wang J, Wang XN, Li CY. Anti-inflammatory effect of the blueberry anthocyanins malvidin-3-glucoside and malvidin- 3-galactoside in endothelial cells. Molecules 2014;19:12827-41.
Jiang M, Deng K, Jiang C, Fu M, Guo C, Wang X, et al. Evaluation of the antioxidative, antibacterial, and anti-inflammatory effects of the aloe fermentation supernatant containing lactobacillus plantarum HM218749.1. Mediators Inflamm 2016;2016. Article ID: 2945650:1-8.
Eghdampour F, Fereshteh J, Khyerkhah M, Taghizadeh M, Naghizadeh S, Hagini H. The impact of Aloe vera and calendula on perineal healing after episiotomy in primiparous women: A randomized clinical trial. J Caring Sci 2013;2:279-86.
Bahadoran Z, Mirmiran P, Azizi F. Potential efficacy of broccoli sprouts as a unique supplement for management of Type 2 diabetes and its complications. J Med Food 2013;16:375-82.
Hwang JH, Lim SB. Antioxidant and anti-inflammatory activities of broccoli florets in LPS-stimulated RAW 264.7 cells. Prev Nutr Food Sci 2014;19:89-97.
Parkinson L, Russell A, Keast R. Molecular mechanisms of inflammation. Anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal. Curr Pharm Des 2011;17:754-68.
Scotece M, Gomez R, Conde J, Lopez V, Gomez-Reino JJ, Lago F, et al. further evidence for the anti-inflammatory activity of Oleo canthal: Inhibition of MIP-1α and IL-6 in J774 macrophages and in ATDC5 chondrocytes. Life Sci 2012;91:1229-35.
Abu-Al-Basal MA. Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced diabetic BALB/c mice. J Ethnopharmacol 2010;131:443-50.
Amaral GP, De Carvalho NR, Barcelos RP, Dobrachinski F, De Lima Portella R, Da Silva MH, et al. Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats. Food Chem Toxicol 2013;55:48-55.
Rocha J, Eduardo-Figueira M, Barateiro A, Fernandes A, Brites D, Bronze R, et al. Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation. Basic Clin Pharmacol Toxicol 2015;116:398-413.
Liang Z, Xu Y, Wen X, Nie H, Hu T, Yang X, et al. Rosmarinic acid attenuates airway inflammation and hyper responsiveness in a murine model of asthma. Molecules 2016;21:769.
Ahmad TB, Rudd D, Benkendorff K, Mahdi LK, Pratt KA, Dooley L, et al. Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury. PLoS One 2017;12:2-3.
Gonzalez Y, Torres-Mendoza D, Jones GE, Fernandez PL. Marine diterpenoids as potential anti-inflammatory agents. Mediat Inflamm 2015;2015. Article ID: 263543:1-14.
Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. Mushrooms: A potential natural source of anti-inflammatory compounds for medical applications. Mediat Inflamm 2014;2014. Article ID: 805841:1-15.
Taofiq O, Helena AS, Calhela CR, Alves MJ, Barros L, Barreiro FM, et al. Development of mushroom-based cosmeceutical formulations with anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial properties. Molecules 2016;21:3-12.
Jedinak A, Dudhgoankar S, Wu Q, Simon J, Sliva D. Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-B and AP-1 signaling. Nutr J 2011;10:52.
Leong AG, Herst PM, Harper JL. Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities. Innate Immun 201218:459-66.
Araâjo JR, Gonçalves P, Martel F. Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr Res 2011;31:77-87.
Hussein SZ, Yusoff KM, Makpol S, Yusof YA. Gelam honey inhibits the production of proinflammatory, mediators NO, PGE (2), TNF-a, and IL-6 in carrageenan-induced acute paw edema in rats. Evid Based Complement Alternat Med 2012;2012. Article ID: 109636,1-13.
Himaya SW, Ryu B, Qian ZJ, Li Y, Kim SK. 1-(5-bromo-2-hydroxy- 4-methoxyphenyl) ethanone [SE1] suppresses pro-inflammatory responses by blocking NF-κB and MAPK signaling pathways in activated microglia. Eur J Pharmacol 2011;670:608-16.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
