FORMULATION DEVELOPMENT AND CHARACTERIZATION OF EFFERVESCENT TABLETS ALONG WITH LEVOCETIRIZINE DIHYDROCHLORIDE

SEMIMUL AKHTAR; SOEB HUSSAIN; SUDIP KUMAR MANDAL

doi:10.22159/ajpcr.2020.v13i8.38058

Authors

SEMIMUL AKHTAR Department of Pharmaceutics, Shri Ram Murti Smarak College of Engineering and Technology (Pharmacy), Bareilly, Uttar Pradesh, India.
SOEB HUSSAIN Department of Pharmaceutics, Shri Ram Murti Smarak College of Engineering and Technology (Pharmacy), Bareilly, Uttar Pradesh, India.
SUDIP KUMAR MANDAL Department of Phrmaceutical Chemistry, Dr. B C Roy College of Pharmacy and Allied Health Sciences, Dr. Meghnad Saha Sarani, Durgapur, West Bengal, India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i8.38058

Keywords:

Levocetirizine dihydrochloride, Effervescent tablet, Direct compression method, citric acid, Sodium bicarbonate

Abstract

Objective: Levocetirizine dihydrochloride is also known as “Xyzol.” Levocetirizine dihydrochloride is a second-generation piperazine derivative, potent H1 selective agent. Levocetirizine dihydrochloride is the active R (-) enantiomer of cetirizine dihydrochloride. In the case of an allergic or histaminic reaction, the medication must respond rapidly. Many older patients, infants, and dysphagia patients have trouble swallowing traditional tablets or capsules. Hence, a need exists for a relatively fast-acting effervescent tablet form.

Methods: The tablets were prepared by direct compression method using citric acid and sodium bicarbonate as effervescent agents. Then, they were tested for parameters of pre- and post-compression. Tablets were evaluated for studies of general appearance, uniformity of substance, hardness, friability, and in vitro dissolution.

Results: More than 90% of the drug was released from almost all the formulations within 1 min. More formulations underwent rapid 90-day stability trials.

Conclusion: No major changes in the taste, disintegration, and dissolution profiles were found in tablets.

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References

Dhiman S, Verma S. Optimization of melt-in-mouth tablets of levocetirizine dihydrochloride using response surface methodology. Int J Pharm Pharm Sci 2012;4:176-84.

Tripathi KD. Essentials of Medical Pharmacology. 8th ed. New Delhi: Jaypee Brothers Medical Publishers; 2018.

Beale JM, Block J. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry. New Delhi: Wolters Kluwer; 2011.

Triggiani M, Gentile M, Secondo A, Granata F, Oriente A, Taglialatela M, et al. Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H receptors. J Immunol 2001;166:4083-91.

Giustizieri ML, Albanesi C, Fluhr J, Gisondi P, Norgauer J, Girolomoni G. H1 histamine receptor mediates inflammatory responses in human keratinocytes. J Allergy Clin Immunol 2004;114:1176-82.

Lachman L, Liberman HA, Kaing JL. The Theory and Practice of Industrial Pharmacy. 3rd ed. Bombay: Varghese Publishing House; 1987.

Bagul U, Gujar K, Patel N, Aphale S, Dhat S. Formulation and evaluation of sublimed fast melt tablets of levocetirizine dihydrochloride. Int J Pharm Sci 2010;2:76-80.

Tokola RA. The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine. Cephalalgia 1988;8:139-47.

Liberman HA, Lachman L, Schwartz JB. Pharmaceutical Dosage Forms Tablet. 2nd ed. New York: Marcel Dekkerinc; 2005.

Ipci K, Öktemer T, Birdane L, Altintoprak N, Muluk NB, Passali D, et al. Effervescent tablets: A safe and practical delivery system for drug administration. ENT Updates 2016;6:46.

Aslani A, Jahangiri H. Formulation, characterization and physicochemical evaluation of ranitidine effervescent tablets. Adv Pharm Bull 2013;3:315-22.

Niazi SK. Hand Book of Preformulation. New York: Informa Health Care; 2007.

Sinko PJ. Martin‘s Physical Pharmacy and Pharmaceutical Sciences. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006.

Aslani A, Eatesam P. Design, formulation and physicochemical evaluation of acetaminophen effervescent tablets. JRPS 2013;2:140-9.

Aulton ME. Pharmaceutics the Science of Dosage Form Design. 2nd ed. Philadelphia, PA: Churchill Livingstone; 2005.

Zhou Q, Armstrong B, Larson I, Stewart PJ, Morton DA. Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating. J Pharm Sci 2010;99:969-81.

Manthena PK, Artham S. Formulation and evaluation of sustained release tablets of quinapril HCL. Pharm Innov J 2014;2:13.

Amareshwar S, Vishwanadham Y, Prashanthi Y, Sreekanth D. Development and in vitro characterization of probenecid rapidly disintegrating tablets by using different co-processed super disintegrants. Nov Appro Drug Des Dev 2017;3:555611.

Neeharika J, Kishore BR, Reddy BM. Formulation and evaluation of candesartan cilexetil immediate release tablets. IRJP 2012;3:271-84.

Kumar YG. Preparation and evaluation of sustained release matrix tablets of bosentan by using wet granulation technique. Int J Pharm Sci Rev Res 2015;31:155-61.

Jagdale S, Gattani M, Bhavsar D, Kuchekar B, Chabukswar A. Formulation and evaluation of chewable tablet of levamisole. Int J Res Pharm Sci 2010;1:282-9.

Manikandan M, Kannan K, Thirumurugu S, Manavalan R. Design and evaluation of amlodipine besilate and atorvastatin calcium tablets. RJPBCS 2012;3:425-34.

Kumare MM, Marathe RP, Kawade RM, Ghante MH, Shendarkar GR. Design of fast dissolving tablet of atenolol using novel co-processed super disintegran. Asian J Pharm Clin Res 2013;6:81-5.

Babu VR, Mallikarjun R, Sayeed A, Rao PR. Design and evaluation of mini-tablets-pulsatile drug delivery system of ramipril. Indo Am J Pharm Sci 2018;5:1839-49.

Guggilla SG. Fast Dissolving Tablets. Available from: http://www.lulu. com.

Schiermeier S, Schmidt PC. Fast dispersible ibuprofen tablets. Eur J Pharm Sci 2002;15:295-305.

Design and in-vitro Evaluation of Mouth Dissolving Tablets of Rosiglitazone Maleate by Using Novel Coprocessed Superdisintegrants. Available from: https://www.pharmatutor.org/articles/design-and-invitro-evaluation-of-mouth-dissolving-tablet-of-rosiglitazone-maleate-by-novel-coprocessed-superdetergants?page=1%2C0.

Devi NA, Priya PV, Sharma JV, Rao AS. Formulation optimization and evaluation of tramadol oral disintegrating tablets. Int J Pharm Sci Rev Res 2013;18:38-41.

Shirsand SB, Shivanand, Shailashri, Keshavshetti G, Jonathan V. Hibiscus sabdariffa mucilage as a disintegrant in formulating fast dissolving tablets. J Pharm Sci 2016;15:143-9.

Stops F, Fell JT, Collett JH, Martini LG. Floating dosage forms to prolong gastro retention-the characterisation of calcium alginate beads. Int J Pharm 2008;350:301-11.

Kulkarni AR, Soppimath KS, Aminabhavi TM, Rudzinski WE. In vitro release kinetics of cefadroxil loaded sodium alginate interpenetrating network beads. Eur J Pharm Biopharm 2001;51:127-33.