DRUG UTILIZATION STUDY IN THE ORTHOPEDICS OUTPATIENT DEPARTMENT OF A TERTIARY CARE HOSPITAL IN MAHARASHTRA

Madhuri Kulkarni; Anant Patil

doi:10.22159/ajpcr.2018.v11i9.26543

Authors

Madhuri Kulkarni Department of Pharmacology, Government Medical College, Aurangabad, Maharashtra, India.
Anant Patil epartment of Pharmacology, Dr. DY Patil Medical College, Navi Mumbai, Maharashtra, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i9.26543

Keywords:

Orthopedics, Outpatient, Prescription pattern

Abstract

Objective: The objective of this study was to analyze the pattern of drug utilization in outpatients of orthopedics department from a tertiary care hospital.

Material and Methods: In this retrospective study, prescriptions of randomly selected patients attending orthopedics clinic were screened to analyze a number of medicines per prescription. Number and percentages of prescribed medicines were calculated.

Results: In this study, 512 patients (male 260 [50.8%] and females 252 [49.2%]) were included in the study. The total number of prescribed medicines was 1562, accounting for 3.1 medicines per patient. A total number of oral, parenteral, and topical medicines were 1375 (88%), 176 (11.3%), and 11 (0.7%), respectively. Nonsteroidal anti-inflammatory agents (NSAIDs), antacid/anti-ulcerants, and antimicrobial agents were 641 (41%), 371 (23.8%), and 102 (6.5%), respectively. A total of 54 (52.9%), 29 (28.4%), 9 (8.8%), 6 (5.9%), 3 (2.9%), and 1 (1%) patients were prescribed fluoroquinolones, beta-lactam antibiotics, metronidazole, trimethoprim plus sulfamethoxazole, macrolides, and doxycycline, respectively. For 371 (23.8%) patients, anti-ulcerant and antiulcer were prescribed, among which ranitidine was the most common prescription [353 (95.1%)]

Conclusion: Number of medicines prescribed per patient in orthopedic clinic was 3.1. NSAIDs and antacid/anti-ulcerants were the most commonly prescribed medicines.

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References

Truter I. A review of drug utilization studies and methodologies. Jordan J Pharm Sci 2008;1:91-103.

Ahmed M, Ali N, Ur Rahman Z, Khan Md M. A study on prescribing patterns in the management of arthritis in the department of orthopaedics. Pharm Lett 2012;4:5-27.

Sadeghian GH, Safaeian L, Mahdanian AR, Salami S, Kebriaee- Zadeh J. Prescribing quality in medical specialists in Isfahan, Iran. Iran J Pharm Res 2013;12:235-41.

Patel S, Gajjar B. Evaluation and comparison of prescribing pattern of general practitioners from public and private sectors. Natl J Physiol Pharm Pharmacol 2012;2:33-8.

Nair B, Taylor-Gjevre R. A review of topical diclofenac use in musculoskeletal disease. Pharmaceuticals (Basel) 2010;3:1892-908.

Manohar VS, Vinay M, Jayasree T, Kishan PV, Ubedulla S, Dixit R. Prescribing pattern of gastro protective agents with non-steroidal anti inflammatory drugs. J Pharmacol Pharmacother 2013;4:59-60.

Jayakumari S, Krishna AG. Prescription pattern analysis of anti-inflammatory drugs in general medicine and surgery department at a tertiary care hospital. Int J Pharm Pharm Sci 2016;8:114-8.

Shankar PR, Pai R, Dubey AK, Upadhyay DK. Prescribing patterns in the orthopaedics outpatient department in a teaching hospital in Pokhara, western Nepal. Kathmandu Univ Med J (KUMJ) 2007;5:16 21.

Matveev AV, Koniaeva EI. Diclofenac sodium in osteoarthritis. Is there risk of hepatotoxicity? A systematic review. Eksp Klin Gastroenterol 2010;10:93-100.

Choudhury DK, Bezbaruah BK. Prescribing pattern of analgesics in orthopedic in-patient department at tertiary care hospital in Guwahati, Assam, Northeast India. Indian J Pharmacol 2016;48:477-381.

Agrawal P, Agrawal VK. Evaluation of analgesics use in orthopedic department at tertiary care hospital in Bareilly, Uttar Pradesh, India. Int J Basic Clin Pharmacol 2016;5:2538-41.

Sen S, Bathini P. Auditing analgesic use in post-operative setting in a teaching hospital. J Clin Diagn Res 2015;9:FC01-4.

Nalini R, Ezhilramya J. A comparative study of efficacy and safety of lornoxicam and diclofenac as postoperative analgesics after mastoidectomy surgery. Int J Pharm Pharm Sci 2017;9:77-83.

Lazzaroni M, Porro GB. Management of NSAID-induced gastrointestinal toxicity: Focus on proton pump inhibitors. Drugs 2009;69:51-69.

Yuan JQ, Tsoi KK, Yang M, Wang JY, Threapleton DE, Yang ZY, et al. Systematic review with network meta-analysis: Comparative effectiveness and safety of strategies for preventing NSAID-associated gastrointestinal toxicity. Aliment Pharmacol Ther 2016;43:1262-75.

Shin SJ, Noh CK, Lim SG, Lee KM, Lee KJ. Non-steroidal anti-inflammatory drug-induced enteropathy. Intest Res 2017;15:446-55.

Sharma T, Dutta S, Dhasmana DC. Prescribing pattern of NSAIDs in orthopaedic OPD of a tertiary care teaching hospital in Uttaranchal. JK Sci 2006;8:160-2.

Tabish A, Jha RK, Rathod AM, Rathod RM, Gupta VK. Prescribing trend of analgesics in a tertiary health care setup of rural Vidarbha: A critical appraisal. Res J Pharm Biol Chem Sci 2012;3:566-71.

Tsumura H, Tamura I, Tanaka H, Chinzei R, Ishida T, Masuda A, et al. Prescription of nonsteroidal anti-inflammatory drugs and co-prescribed drugs for mucosal protection: Analysis of the present status based on questionnaires obtained from orthopedists in Japan. Intern Med 2007;46:927-31.

Kumar A, Dalai CK, Ghosh AK, Ray M. Drug utilization study of co-administration of nonsteroidal anti-inflammatory drugs and gastro protective agents in an orthopaedics outpatients department of a tertiary care hospital in West Bengal. Int J Basic Clin Pharmacol 2013;2:199 202.

Clark K, Lam LT, Gibson S, Currow D. The effect of ranitidine versus proton pump inhibitors on gastric secretions: A meta-analysis of randomised control trials. Anaesthesia 2009;64:652-7.

Massey T, Derry S, Moore RA, McQuay HJ. Topical NSAIDs for acute pain in adults. Cochrane Database Syst Rev 2010;6:CD007402.

Sharma PC, Jain A, Jain S, Pahwa R, Yar MS. Ciprofloxacin: Review on developments in synthetic, analytical, and medicinal aspects. J Enzyme Inhbib Med Chem 2010;25:577-89.

Zhang GF, Liu X, Zhang S, Pan B, Liu ML. Ciprofloxacin derivatives and their antibacterial activities. Eur J Med Chem 2018;146:599-612.

Butranova OI, Razdrogina TN. Antibiotics for skin and soft tissues infections in Type 2 diabetes mellitus. Int J Risk Saf Med 2015;27 Suppl 1:S57-8.

Abhijit K, Jain P, Upadhaya P, Jain S. Antibiotic prescribing in various clinical departments in a tertiary care teaching hospital in northern India. J Clin Diagn Res 2014;8:HC09-11.