PRESCRIPTION PATTERN ANALYSIS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN TERTIARY CARE HOSPITAL

ZEBA INAMDAR; SARWAMANGALA SN; PADMAVATI V; VARSHA I DALAL; PRASAD N BALI

doi:10.22159/ajpcr.2022.v15i7.44669

Authors

ZEBA INAMDAR Department of Pharmacy Practice, KLE College of Pharmacy, Hubballi, Hubli, Karnataka, India.
SARWAMANGALA SN Department of Pharmacy Practice, KLE College of Pharmacy, Hubballi, Hubli, Karnataka, India.
PADMAVATI V Department of Pharmacy Practice, KLE College of Pharmacy, Hubballi, Hubli, Karnataka, India.
VARSHA I DALAL Department of Pharmacy Practice, KLE College of Pharmacy, Hubballi, Hubli, Karnataka, India.
PRASAD N BALI Department of Pharmacy Practice, KLE College of Pharmacy, Hubballi, Hubli, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i7.44669

Keywords:

NSAIDs, Cyclooxygenase enzyme, Prescription pattern, Gastro protective agent, Analgesic, Anti-pyretic, Anti-inflammatory

Abstract

Objective: The aim of the study was to analyze the prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and to identify the commonly used NSAIDs and their drug-related problems (DRPs).

Methods: A prospective and cross-sectional study on prescription pattern analysis of NSAIDs was conducted for the period of 6 months.

Results: Prescriptions of 150 patients containing at least one NSAIDs were analyzed. About 56% of the prescription were prescribed for males and 44% prescription were female. NSAIDs were more prescribed for below 60-year age group (47%) but were most frequently used by 61–70-year age group (21%). Subjects were regularly prescribed with acetaminophen (95%) and diclofenac (22%). Among all the prescriptions, (19%) of the prescriptions contained NSAIDs in the form of fixed dose combinations (FDCs). About 37% of prescriptions had other analgesic coprescribed along with NSAIDs amid which tramadol was in majority (22%). Prescription was also coprescribed with antibiotic (90%) and gastroprotective agents (GPAs) (97%) that consisted of pantoprazole belonging to the class of proton pump inhibitors which was the persistently prescribed GPA (86%). Due to coprescription, (3%) suspected drug-drug interactions (DDIs) were observed.

Conclusion: The goal of studying prescribing patterns was to monitor, assess, and, if required, advise changes in medical practitioners’ prescribing behavior to offer quality medical treatment and reasonable drug use. The prescribing pattern was rational and in accordance with national list of essential medicine (NLEM-2015) but was not in accordance with the World Health Organization (WHO) model list of essential medicines.

Downloads

Download data is not yet available.

References

Kumar S, Thakur PK, Sowmya K, Priyanka S. Evaluation of prescribing pattern of NSAIDs in south Indian teaching hospital. J Chitwan Med Coll 2017;6:54-8. doi: 10.3126/jcmc.v6i4.16716

Motagahre VM, Bajait CS, Turankar A, Pinmpalkhute SA, Dholpure M. Prescription pattern and adverse drug reaction profile of drugs prescribed with focus on NSAIDs for orthopedic indiations at a tertiary care hospital. Indian J Pharm Pharmacol 2016;3:178-81.

Mishra R, Keshari SS. Prescription pattern of analgesics in outpatient department in a tertiary care teaching hospital in North India. Int J Basic Clin Pharmacol 2017;6:2372. doi: 10.18203/2319-2003.ijbcp20174361

Dulal P, Muhammad Khan G. Assessment of nonsteroidal anti-inflammatory drugs prescription pattern and gastrointestinal risk factors in a tertiary care hospital of Western Nepal. J Health Allied Sci 2019;9:59-64. doi: 10.37107/jhas.11

Antappan AP, Micheal BP, Thelappilly MA, Bagum T, Mathew L, Panayappan L, et al. Prescription pattern of NSAIDS and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients. Indian J Pharm Biol Res 2017;5:17-25. doi: 10.30750/ijpbr.5.3.3

Alshakka MA, Badullah WF, Alolayan SO, Mahmoud MA. Prescribing patterns of non-steroidal anti-inflammatory drugs (NSAIDs) at outpatient departments of four hospitals. Biomed Res 2018;29:3643-7. doi: 10.4066/biomedicalresearch.29-18-1072

Zeinali M, Tabeshpour J, Maziar SV, Taherzadeh Z, Zirak MR, Sent D, et al. Prescription pattern analysis of nonsteroidal anti-inflammatory drugs in the northeastern Iranian population. J Res Pharm Pract 2017;6:206-10. doi: 10.4103/jrpp.JRPP_17_45, PMID 29417079

Jayakumari S, Krishna G. Prescription pattern analysis of anti-inflammatory drugs in general medicine and surgery department at a tertiary care hospital. Int J Pharm Pharm Sci 2016;8:114-8.

Raghavendra B, Narendranath S, Ullal S, Kamath R, Pai M, Kamath S, et al. Trends in prescribing gastroprotective agents with non-steroidal anti-inflammatory drugs in an orthopaedic outpatient unit of a tertiary care hospital. J Clin Diagn Res 2009;3:1553-5.

National List of Essential Medicine; 2015. Available from: https://www. main.mohfw.gov.in/fooddrugs/national-list-essential-medicinesnlem- 2015-annexure-iv

WHO Model List of Essential Medicines. Available from: https://www. list.essentialmeds.org