NEPHROPROTECTIVE ACTIVITY OF ETHANOL EXTRACT OF CURCUMA MANGGA VAL. IN PARACETAMOL-INDUCED MALE MICE
DOI:
https://doi.org/10.22159/ajpcr.2018.v11s1.26585Keywords:
Curcuma mangga, Serum creatinine, HistopathologyAbstract
Objective: This study aimed to evaluate nephroprotective activity of Curcuma mangga in paracetamol-induced male mice.
Methods: Male mice were divided into several groups including normal control, negative, positive, and treatment groups. Treatment groups were orally administered with C. mangga extract at doses of 100, 200, and 400 mg/kg bw for 7 days. On day 7after 1 h of treatment, the mice were induced with paracetamol 1.05 g/kg bw. Serum creatinine level measurement and histopathotlogy study were performed at the end of experiment.
Results: C. mangga extract was able to inhibit the increase of creatinine level and showed a significantly different from negative control (p<0.05) and did not different significantly from positive control (p>0.05). The result was supported by histopathology examination which did not show any cell damage. The nephroprotective effect of C. mangga was in a dose-dependent manner. C. mangga extract at dose of 400 mg/kg bw depicted the strongest nephroprotective effect.
Conclusion: C. mangga extract was able to protect mice kidney induced by paracetamol.
Downloads
References
Blakely P, McDonald BR. Acute renal failure due to acetaminophen ingestion a case report and review of the literature. J Am Soc Nephrol 1995;6:48-53.
Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: Pathophysiology, clinical manifestations and management. J Med Toxicol 2008;4:2-6.
Wong KC, Chong TC, Chee SG. Essential oil of Curcuma mangga val. and zijp rhizomes. J Essent Oil Res 1999;11:349-51.
Cekmen M, Ilbey YO, Ozbek E, Simsek A, Somay A, Ersoz C. Curcum in prevents oxidative renal damage induced by acetaminophen in rats. Food Chem Toxicol 2009;47:1480-4.
Khorshandi L. Protective effect of Curcuma longa extract on acetaminophen induced nephrotoxicity in mice. DARU J Pharm Sci 2008;16:155-9.
Boulares AH, Zoltoski AJ, Stoica BA, Cuvillier O, Smulson ME. Acetaminophen induces a caspase-dependent and bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes. Pharmacol Toxicol 2002;90:38-50.
Mitruka BM. Clinical Biochemical and Hematological Reference Values in Normal Experimental Animal and Normal Humans. Philadelphia, PA: Book Medical Publisher; 1981. p. 155-9.
Adeneye AA, Olagunju JA, Benebo AS, Elias SO, Adisa AO, Idowu BO, et al. Nephro protective effects of the aqueous root extract of Harungana madagascariensis(l.) in acute and repeated dose acetaminophen renal injured rats. Int J Appl Res Nat Prod 2008;1:6-14.
Schnellman RG. Toxic responses of the kidney. In: Casarett and Doull`S Toxicology. The Basic Science of Poisons. 6th ed. New York: McGraw- Hill Medical Publishing Division; 2001. p. 86-7.
Ray SD, Jena N. A hepatotoxic of acetaminophen modulates expression of bcl-xl, and bcl-x5 during apoptotic and necrotic cell death of mouse liver cells in vivo. Arch Toxicol 2000;73:594-606.
Palani S, Raja S, Kumar RP, Jayakumar S, Kumar BS. Therapeutic efficacy of Pimpinella tirupatiensis(apiaceae) on acetaminophen induced nephrotoxicity and oxidative stress in male albino rats. Int J PharmTech Res 2009;1:925-34.
Gosh A, Sil PC. Anti-oxidative effect of a protein from Cajanus indicusl against acetaminophen-induced hepato-nephro toxicity. J Biochem Mol Biol 2007;40:1039-49.
Singh D, Kaur R, Chander V, Chopra K. Antioxidant in the prevention of renal disease. J Med Food 2006;9:443-50.
Corwin EJ. Handbook of Pathophysiology. 3th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins 2009.
Ismail AF, Asmaa AM. Renoprotective effect of curcumin on acetaminophen-induced nephrotoxicity in rats. J Chem Pharm Res 2016;8:773-9.
Lorz C, Justo P, Sanz AB, Egido J, Ortiz A. Role of Bcl-xL in paracetamol-induced tubular epithelial cell death. Kidney Int 2005;67:14-8.
Inagi R. Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury. Nephron Exp Nephrol 2009;112:e1-9.
Goodman LS, Gilman A. The pharmacological basis of therapeutics. 11th ed. USA: McGraw-Hill; 2006. p. 729-30.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
