VIRGIN COCONUT OIL MODULATES TCD4+ AND TCD8+ CELL PROFILE OF DOXORUBICIN-INDUCED IMMUNE-SUPPRESSED RATS

Jansen Silalahi; Rosidah; Yuandani; Denny Satria

doi:10.22159/ajpcr.2018.v11s1.26562

Authors

Jansen Silalahi Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Rosidah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Yuandani Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26562

Keywords:

Virgin coconut oil, Immune, Doxorubicin, TCD4 , TCD8

Abstract

Â Objective: Doxorubicin (DOX) is a drug of choice in many cancer therapies. Virgin coconut oil (VCO) is one of nutraceutical which has many biology activities. This current study was carried out to investigate the VCO activity in modulating TCD4+, and TCD8+ cells profile toward rats which induced by DOX.

Methods: A total of 15 Sprague-Dawley rats were divided into three groups consisting of five rats each as follows: Group 1, receiving oral saline 10 mL Kg BW (control group); Group 2, receiving oral saline 10 mL/kg BW; and Group 3, receiving VCO 5 mL/kg BW. Group 2 and 3 were administered with DOX intramuscularly at dose 4.67 mg/kg BW at day 1 and 4 to suppressed immune functions.

Results: Treatment of VCO 5 mL/kg BW succeeded in reducing a side effect of DOX based on increasing the TCD4+ and TCD8+ blood level.

Conclusion: The results reveal that VCO could increase the level of TCD4+ and TCD8+ in rats which induced by DOX.

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