CYTOTOXICITY ACTIVITY OF PICRIA FEL-TERRAE LOUR. HERBS AGAINST 4T1 AND MCF-7 BREAST CANCER CELLS

Urip Harahap; Poppy Anjelisa Zaitun Hasibuan; Panal Sitorus; Denny Satria

doi:10.22159/ajpcr.2018.v11s1.26608

Authors

Urip Harahap Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.
Poppy Anjelisa Zaitun Hasibuan Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.
Panal Sitorus Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.
Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26608

Keywords:

Cytotoxicity, Picria fel-terrae Lour, Herbs, Fractions, Cell lines

Abstract

Â Objective: This study was carried out to investigate the cytotoxic activity toward 4T1 and MCF-7 cell lines of Picria fel-terrae Lour. herb fractions.

Methods: P. fel-terrae Lour. herb powder was extracted by maceration method with n-hexane, ethyl acetate, and ethanol solvent. In vitro study was using MTT method toward 4T1 and MCF-7 cell lines.

Results: The inhibitory concentration 50% was 234.10 Â± 7.85, 50.49 Â± 1.07, and 212.53 Â± 7.55 Î¼g/mL for 4T1 and 84.62 Â± 1.44, 56.79 Â± 0.22, and 235.51 Â± 4.77 Î¼g/mL for MCF-7 cell lines, respectively.

Conclusion: The results reveal that P. fel-terrae Lour. herb fractions provide effective as anticancer. Our further study is to assess the mechanism of ethyl acetate fraction in inhibit angiogenesis and metastatic in breast cancer.

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