THE EFFECT OF HYDROLYZED VIRGIN COCONUT OIL ON LIPID PROFILE AND LIVER ENZYMES IN DYSLIPIDEMIC RATS

Linda Margata; Jansen Silalahi; Urip Harahap; Denny Satria

doi:10.22159/ajpcr.2018.v11i10.27476

Authors

Linda Margata Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Jansen Silalahi Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Urip Harahap Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i10.27476

Keywords:

Virgin coconut oil, Hydrolyzed virgin coconut oil, Enzymatic hydrolysis, Dyslipidemia, Lipid profile, Liver enzymes

Abstract

Objective: The objective of this study was to investigate the effect of virgin coconut oil (VCO) and hydrolyzed VCO (HVCO) on lipid profile and liver enzymes in dyslipidemic rats.

Methods: VCO was hydrolyzed using lipase from Rhizomucor miehei (active on sn-1,3 position). Thirty male rats (150â€“200 g) were induced with 2 ml/kg body weight (BW) egg yolk and lard oil twice a day for 30 days. Rats were divided into six groups which were given with sodium carboxymethylcellulose 0.5%, atorvastatin, VCO (4 and 6 ml/kg BW), and HVCO (4 and 6 ml/kg BW). Lipid profile including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL-C), and liver enzymes including serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were measured after 14 days of treatment.

Results: The results of this study show that VCO and HVCO improve lipid profile (decrease in TC, TG, LDL-C, and VLDL-C, but increase in HDL-C). VCO and HVCO also lower atherogenic index, TC/HDL-C ratio, LDL-C/HDL-C ratio, SGOT, and SGPT. Result shows that HVCO improves lipid profile and liver enzymes better than VCO does.

Conclusion: VCO and HVCO improve lipid profile in dyslipidemic rats, not atherogenic, and not toxic to the liver. HVCO causes better lipid profile improvement, especially with 6 ml/kg BW dosage.

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Author Biography

Linda Margata, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Pharmaceutical Chemistry

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