PHYSICOCHEMICAL PROPERTIES, PHYTOCHEMICAL SCREENING, AND ANTIHYPERGLYCEMIC ACTIVITY OF INAI (LAWSONIA INERMIS L.) LEAVES ACTIVE FRACTION ON STREPTOZOTOCININDUCED DIABETIC MICE

Authors

  • Fazrina Zahara Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia
  • Urip Harahap Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia
  • Ginda Haro Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i5.23504

Keywords:

Antihyperglycemic, Diabetic, Inai, Streptozotocin, Mice

Abstract

 Objective: This study was designed to explore the preliminary phytochemical and physicochemical analysis of Inai (Lawsonia inermis L.) leaves and further evaluation of its antihyperglycemic effect on diabetic rats from its active fraction.

Methods: The study begins with making the powder of Inai (L. inermis L.) leaves and then evaluates the physicochemical characterization. The powder of Inai leaves was fractionated and performed by the standard phytochemical screening method and streptozotocin-induced diabetic mice for evaluated the antihyperglycemic effect of Inai leaves.

Result: The physicochemical evaluation showed that the powder of Inai leaves has a good and high purity level; while the phytochemical screening showed that Inai leaves fractions have various phytoconstituents. The active fraction which was obtained from ethyl acetate fraction showed a significant reduction of the blood glucose.

Conclusion: The leaves of Inai (L. inermis L.) have the antihyperglycemic activity.

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Author Biographies

Fazrina Zahara, Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia

Department of Pharmacology

Urip Harahap, Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia

Department of Pharmacology

Ginda Haro, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

Department of Pharmaceutical Chemistry

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Published

01-05-2018

How to Cite

Zahara, F., U. Harahap, and G. Haro. “PHYSICOCHEMICAL PROPERTIES, PHYTOCHEMICAL SCREENING, AND ANTIHYPERGLYCEMIC ACTIVITY OF INAI (LAWSONIA INERMIS L.) LEAVES ACTIVE FRACTION ON STREPTOZOTOCININDUCED DIABETIC MICE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 5, May 2018, pp. 68-71, doi:10.22159/ajpcr.2018.v11i5.23504.

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