PREDICTION OF ANTI-PARKINSON POTENTIAL OF PHYTOCONSTITUENTS USING PREDICTION OF ACTIVITY SPECTRA OF SUBSTANCES SOFTWARE
DOI:
https://doi.org/10.22159/ajpcr.2018.v11s2.28578Keywords:
Nil, Prediction of activity spectra of substances, Levodopa, Postural instabilityAbstract
Objective: Neurodegenerative disorders are group of diseased conditions in which there is loss of neuron cells occur. The main objective of this study to find/search out the phytochemical with the help of prediction of activity spectra of substances (PASSs), those show maximum activity over the selected targets of the Parkinson's disease (PD).
Methods: PASSs is a valuable software which is used in this study, to predict the anti-Parkinson activity of different compounds. Canonical simplified molecular-input line-entry system is used for the prediction of anti-Parkinson activity which is obtained from PubChem website. The predicted activity also compared with marketed compound like levodopa.
Results: From the study, it was found that resveratrol was the only compound which has the activity on all the selected targets. On the other hand, stemazole and celastrol were found to have the least active compounds as both have the activity only on a single target.
Conclusion: In this research work, we tried to compile the information regarding the PASS predicted anti-Parkinson activity of some important phytoconstituents. We found that resveratrol can be a target for further investigation in the development of drug therapy for PD.
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Shahpiri Z, Bahramsoltani R, Farzaei MH, Farzaei F, Rahimi R. Phytochemicals as future drugs for Parkinson’s disease: A comprehensive review. Rev Neurosci 2016;27:651-68.
Gopalakrishna A, Alexander SA. Complex and multifaceted illness. J Neurosci Nurs 2015;47:320-6.
Bassani TB, Gradowski RW, Zaminelli T, Barbiero JK, Santiago RM, Boschen SL, et al. Neuroprotective and antidepressant-like effects of melatonin in a rotenone-induced Parkinson’s disease model in rats. Brain Res 2014;1593:95-105.
Moon HE, Paek SH. Mitochondrial dysfunction in Parkinson’s disease. Exp Neurobiol 2015;24:103.
Bais S, Gill NS, Kumar N. Neuroprotective effect of Juniperus communis on chlorpromazine induced Parkinson disease in animal model. Chin J Biol 2015;2015:3-9.
Sharifi H, Mohajjel Nayebi A, Farajnia S, Haddadi R. Effect of buspirone, fluoxetine and 8-OH-DPAT on striatal expression of bax, caspase-3 and bcl-2 proteins in 6-hydroxydopamine-induced hemi-parkinsonian rats. Adv Pharm Bull 2015;5:491-5.
Jamkhande PG, Barde SR. Evaluation of anthelmintic activity and in silico PASS assisted prediction of Cordia dichotoma (Forst.) root extract. Anc Sci Life 2014;34:39-43.
Khurana N, Ishar MP, Gajbhiye A, Goel RK. PASS assisted prediction and pharmacological evaluation of novel nicotinic analogs for nootropic activity in mice. Eur J Pharmacol 2011;662:22-30.
Anand A, Sharma N, Khurana N. Prediction of activity spectra of substances assisted prediction of biological activity spectra of potential anti-Alzheimer’s phytoconstituents. Asian J Pharm Clin Res 2017;10:13-21.
Habibyar AF, Sharma N, Khurana N. PASS assisted prediction and pharmacological evaluation of hesperidin against scopolamine induced amnesia in mice. Eur J Pharmacol 2016;789:385-94.
Katzenschlager R, Lees AJ. Treatment of Parkinson’s disease: Levodopa as the first choice. J Neurol 2002;249 Suppl 2:II19-24.
Quik M, Parameswaran N, McCallum SE, Bordia T, Bao S, McCormack A, et al. Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates. J Neurochem 2006;98:1866-75.
Khadrawy YA, Salem AM, El-Shamy KA, Ahmed EK, Fadl NN, Hosny EN. Neuroprotective and therapeutic effect of caffeine on the rat model of Parkinson’s disease induced by rotenone. J Diet Suppl 2017;14:553-72.
Wang Y, Xu H, Fu Q, Ma R, Xiang J. Protective effect of resveratrol derived from Polygonum cuspidatum and it’s liposomal form on nigral cells in parkinsonian rats. J Neurol Sci 2011;304:29-34.
Araki T, Kumagai T, Matsubara M, Ido T, Imai Y, Itoyama Y, et al. Protective effect of riluzole on MPTP-induced depletion of dopamine and its metabolite content in mice. Metab Brain Dis 2000;15:193-201.
Antunes MS, Goes AT, Boeira SP, Prigol M, Jesse CR. Protective effect of hesperidin in a model of Parkinson’s disease induced by 6-hydroxydopamine in aged mice. Nutrition 2014;30:1415-22.
Mu X, He G, Cheng Y, Li X, Xu B, Du G, et al. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental Parkinsonism in vivo and in vitro. Pharmacol Biochem Behav 2009;92:642-8.
Fu RH, Wang YC, Chen CS, Tsai RT, Liu SP, Chang WL, et al. Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson’s disease. Neuropharmacology 2014;82:108-20.
Fu RH, Harn HJ, Liu SP, Chen CS, Chang WL, Chen YM, et al. N-Butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson’s disease. PLoS One 2014;9:e85305.
Guo Z, Xu S, Du N, Liu J, Huang Y, Han M, et al. Neuroprotective effects of stemazole in the MPTP-induced acute model of Parkinson’s disease: Involvement of the dopamine system. Neurosci Lett 2016;616:152-9.
Cleren C, Calingasan NY, Chen J, Beal MF. Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. J Neurochem 2005;94:995-1004.
Cho HS, Kim S, Lee SY, Park JA, Kim SJ, Chun HS. Protective effect of the green tea component, L-theanine on environment toxins-induced neuronal cell death. Neurotoxicology 2008;29:656-62.
Shen LI. Neuroprotective effect of kaempferol against a 1-Methyl- 4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson’s disease. Biol Pharm Bull 2011;34:1291-6.
Wu CR, Tsai CW, Chang SW, Lin CY, Huang LC, Tsai CW, et al. Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction. Chem Biol Interact 2015;225:40-6.
Kumar H, Kim IS, More SV, Kim BW, Bahk YY, Choi DK. Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson’s disease model, evidence-based complement. Altern Med 2013;2013:514095.
Sarkar S, Chigurupati S, Raymick J, Mann D, Bowyer JF, Schmitt T, et al. Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson’s disease mouse model. Neurotoxicology 2014;44:250-62.
Du T, Li L, Song N, Xie J, Jiang H. Rosmarinic acid antagonized 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in MES23.5 dopaminergic cells. Int J Toxicol 2010;29:625-33.
Park G, Kim HG, Ju MS, Ha SK, Park Y, Kim SY, et al. 6-shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson’s disease models via anti-neuroinflammation. Acta Pharmacol Sin 2013;34:1131-9.
Kabuto H, Nishizawa M, Tada M, Higashio C, Shishibori T, Kohno M, et al. Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum. Neurochem Res 2005;30:325-32.
Rekha KR, Selvakumar GP, Sivakamasundari RI. Effects of syringic acid on chronic MPTP/probenecid induced motor dysfunction, dopaminergic markers expression and neuroinflammation in C57BL/6 mice. Biomed Aging Pathol 2014;4:95-104.
Patel MY, Panchal HV, Ghribi O, Benzeroual KE. The neuroprotective effect of fisetin in the MPTP model of Parkinson’s disease. J Park Dis 2012;2:287-302.
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