ASSESSMENT OF POTENTIAL DRUG INTERACTIONS AMONG HOSPITALIZED PATIENTS IN NEUROLOGY DEPARTMENT IN TERTIARY CARE HOSPITALS

DIJO DAIS; RANJEET AVIS CHERUVATHOOR; KAMESWARAN R; SHANMUGA SUNDARAM RAJAGOPAL

doi:10.22159/ajpcr.2019.v12i3.29484

Authors

DIJO DAIS Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam, Tamil Nadu, India.
RANJEET AVIS CHERUVATHOOR Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam, Tamil Nadu, India.
KAMESWARAN R Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam, Tamil Nadu, India.
SHANMUGA SUNDARAM RAJAGOPAL Department of Pharmacology, J.K.K. Nattraja College of Pharmacy, Kumarapalayam, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i3.29484

Keywords:

Neurology, Drug-drug interactions, Risk factors

Abstract

Objective: This research was instigated to determine and assess the prevalence, severity, type, and the total number of potential drug interactions in the neurology department of two hospitals in India.

Methods: The data were collected from the prescriptions and by patient history interview on a daily basis. The drug-drug interactions (DDIs) were identified using Micromedex® database-2.7 and drugs.com.

Results: The drug interactions were influenced by a plethora of risk factors: Gender, age, comorbidities, length of hospital stay, and the neurological condition. The study was comprised 320 patients, among 196 patients were identified with potential DDIs (PDDIs), and a total of 450 PDDIs were observed. The prevalence of PDDIs according to the severity was major (42.6%), moderate (45.11%), and minor (12.22%).

Conclusion: To lessen PDDIs, the range of medications for the patients must be properly managed, and it is encouraged to remove all medicines without therapeutic advantage, intention, and an indication.

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