THE CORRELATION BETWEEN FAT INTAKE AND PLASMA SUPEROXIDE DISMUTASE ACTIVITY WITH TELOMERE LENGTH OF MINANGKABAU ETHNICITY MEN, IN WEST SUMATERA, INDONESIA

AFRIWARDI AFRIWARDI; DELMI SULASTRI; YUNIAR LESTARI; DESMAWATI DESMAWATI; PRIMA MINERVA

doi:10.22159/ajpcr.2019.v12i2.29594

Authors

AFRIWARDI AFRIWARDI Department of Physiology, Faculty of Medical, Andalas University, Padang, West Sumatera, Indonesia.
DELMI SULASTRI Department of Nutrition, Faculty of Medical, Andalas University, Padang, West Sumatera, Indonesia.
YUNIAR LESTARI Department of Public Health, Faculty of Medical, Undalas University, Padang, West Sumatera, Indonesia.
DESMAWATI DESMAWATI Department of Nutrition, Faculty of Medical, Andalas University, Padang, West Sumatera, Indonesia.
PRIMA MINERVA Master of Biomedical Science Program, Andalas University, Padang, West Sumatera, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i2.29594

Keywords:

Telomere length, Fat, Intake, Total fat, Superoxide dismutase activity

Abstract

Objective: The purpose of this research is to investigate the correlation between fat intake and plasma superoxide dismutase (SOD) enzyme activity with telomere length of Minangkabau ethnic men in West Sumatera, Indonesia.

Materials and Methods: This cross-sectional study was conducted in Padang City in 2016, using a sample of 107 Minangkabau ethnic men, aged between 40 and 50 years. The total fat, saturated fatty acids (SFA), monounsaturated fatty acid (MUFA), and polyunsaturated fatty acid (PUFA) intake were collected using a food frequency questionnaire, and blood sample analysis to measure telomere length and plasma SOD activity.

Results: This research indicated that an average telomere length was 584.59±305.92 bp, fat intake consists of total fat was 27.01±6.68% calorie, SFA was 24,7510.07% calorie, MUFA was 10.24±5.41% calorie, and PUFA was 7.35±3.54% calorie. Average of plasma SOD activity was 5.85±3.41 u/mL. There were no correlations between fat intake (total fat, SFA, MUFA, and PUFA) with telomere length (p>0.05), but there was a significant positive correlation between plasma SOD enzyme activity with telomere length (r=−0.202, p=0.037).

Conclusion: Fat intake within normal limits does not correlate with telomere length, and plasma SOD activity is a risk factor for telomere shortening in ethnic Minangkabau men.

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Author Biographies

AFRIWARDI AFRIWARDI, Department of Physiology, Faculty of Medical, Andalas University, Padang, West Sumatera, Indonesia.

Department of Physiology, Medical faculty of Andalas University

DELMI SULASTRI, Department of Nutrition, Faculty of Medical, Andalas University, Padang, West Sumatera, Indonesia.

Nutrition Department, Medical Faculty, Andalas University

YUNIAR LESTARI, Department of Public Health, Faculty of Medical, Undalas University, Padang, West Sumatera, Indonesia.

public health Department, medical faculty, Andalas University

DESMAWATI DESMAWATI, Department of Nutrition, Faculty of Medical, Andalas University, Padang, West Sumatera, Indonesia.

Nutrition Department, MedicalFaculty,Andalas University

PRIMA MINERVA, Master of Biomedical Science Program, Andalas University, Padang, West Sumatera, Indonesia.

Master of biomedical science program,Andalas University, Padang, West Sumatera, Indonesia

References

Minister of Health RoI. Overview of Non-Communicable Diseases in Indonesia 2009-2010. Jakarta: Data and Information Center; 2012.

WHO Global Global Status Report on Non Communicable Disease Data by Country; 2014. Available from: http://www.apps.who.int/gho/data/node.main.688?lang=en. [Last cited on 2016 feb 14].

Lee M, Martin H, Firpo MA, Demerath EW. Inverse association between adiposity and telomere length: The fels longitudinal study. Am J Hum Biol 2011;23:100-6.

Minister of Health RoI. Plan for Operational Health Promotion in Control of Non-Communicable Diseases. Jakarta: Health Promotion Center; 2010.

Shammas MA. Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care 2011;14:28-34.

Boccardi V, Esposito A, Rizzo MR, Marfella R, Barbieri M, Paolisso G, et al. Mediterranean diet, telomere maintenance and health status among elderly. PLoS One 2013;8:e62781.

Song Z, von Figura G, Liu Y, Kraus JM, Torrice C, Dillon P, et al. Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood. Aging Cell 2010;9:607-15.

Susantiningsih T. Obesitas dan stres oksidatif. J Kedokteran 2013;5:89-93.

Tiainen AM, Männistö S, Blomstedt PA, Moltchanova E, Perälä MM, Kaartinen NE, et al. Leukocyte telomere length and its relation to food and nutrient intake in an elderly population. Eur J Clin Nutr 2012;66:1290-4.

Bollapragada MK, Shantaram M, Kumar S. Obesity: Development, epidemiology, factor affecting, quantity, health hazards, amanagement and natural treatment-a review. Int J Pharm Pharm Sci 2017;9:12-26.

Muchtadi D. Gizi Anti Penuaan Dini. Bandung: Penerbit Alfabeta; 2009.

von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002;27:339-44.

Makino N, Maeda T, Oyama J, Sasaki M, Higuchi Y, Mimori K, et al. Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice. J Mol Cell Cardiol 2011;50:670-7.

Sulastri D, Rahayuningsih S, Purwantyastuti D. Pola asupan lemak, serat, dan antioksidan, serta hubungannya dengan profil lipid pada laki-laki etnik minangkabau. Majalah Kedokteran Indones 2005;55:61-6.

O’Callaghan NJ, Fenech M. A quantitative PCR method for measuring absolute telomere length. Biol Proced Online 2011;13:3.

Guney Y, Bilgihan A, Ciftci TU, Cimen F, Coskun O. Serum malondialdehyde levels and superoxide dismutase activities in pulmonary ankara universitesi dikimevi saglik hizmetleri. Meslek Yüksekokulu Derg 2004;6:33-8.

Lipoeto NI. Kadar Asam Lemak Omega Tigadan Konsumsi Produk Kelapa pada Etnik Minangkabau di Sumatera Barat. Semarang: Proceeding Kongres Nasional PDGMI; 2016.

Hatma RD. Lipid profiles among diverse ethnic groups in Indonesia. Acta Med Indones 2011;43:4-11.

Purwantyastuti P. Relation of Lipid Peroxides to Food Habit, Selected Coronary Heart Disease Risk Factors and Vitamin E Supplementation in the Elderly. Jakarta: Disertasi University of Indonesia; 2000.

Kasielski M, Eusebio MO, Pietruczuk M, Nowak D. The relationship between peripheral blood mononuclear cells telomere length and diet-unexpected effect of red meat. Nutr J 2016;15:68.

Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol 2013;14:1112-20.

Yusrawati Y, Sulastri D, Desmawati D. The correlation between estradiol levels with telomere length based on history of using hormonal contraceptive in premenopausal women Asian J Pharm Clin Res 2018;11:336-9.

Shao HW. Effect of superoxide dismutase and malondialdehyde metabolic changes on carcinogenesis of gastric carcinoma. World J Gastroenterol 2005;11:4305-10.

Wang Y, Zhou WD, Yang Y, Ma L, Zhao Y, Bai Z, et al. Telomeres are elongated in rats exposed to moderate altitude. J Physiol Anthropol 2014;33:19.

Prastuti B, Sunarti S. Pengendalian SOD dan NO pada DMT2 dengan emping garut sebagai makanan selingan. J Gizi Klin Indones 2012;8:118-25.

Kristina H, Sartono N, Rusdi R. Kadar peroksida lipid dan aktivitas superoksida dismutase serum darah pada penderita DMT2. Bioma 2012;12:32-40.

Khairunisa S, Subchan P, Himbawami M. Uji korelasi antara nilai aktivitas superoxide dismutase dalam eristrosit dengan derajat keparahan akne vulgaris pada wanita. MDVI 2011;38:2-5.

Eszy MS, Sastri S, Masri M. Pengaruh pemberian diet tinggi minyak sawit terhadap kadar malondialdehid darahtikus wistar. J Kesehatan Andalas 2014;3:409-14.

Sherzay N, Chitakar E. Epigenetic: Effect of enviromental factors on human genome. Int J Pharm Pharm Sci 2016;8:1-6.