A PROSPECTIVE SINGLE-BLINDED STUDY ON THE SAFETY AND EFFICACY OF ZINC SUPPLEMENTATION IN PULMONARY TUBERCULOSIS

Authors

  • Yeswanth Prasanna Kumar B Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Chennai, India.
  • Praveen D Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Chennai,India.
  • Vijey Aanandhi M Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Chennai, India

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s4.31685

Keywords:

Micronutrient, Pulmonary Tuberculosis, Zinc

Abstract

Aim and Objectives: The aim of the study was to study the serum zinc (Zn) levels, safety, and efficacy of Zn supplementation in pulmonary tuberculosis (PTB) patients.

Methods: A randomized single-blinded study of two groups: Group A received conventional TB therapy while Group B received conventional TB therapy along with 15 mg of Zn tablet. 40 patients were assigned in each group by randomized permuted blocks.

Results: After 8 weeks of treatment in Group A 27 patients and Group B 36 patients were found to be sputum negative with p=0.0421 and 0.0629. After 24 weeks of treatment in Group A 37 patients and Group B 40 patients were found to be sputum negative with p=0.00976 and 0.00971. By this, the given treatment was effective in the patients with PTB.

Conclusion: Zn supplementation improves the effect of TB medication treatment and results in earlier sputum smear conversion.

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References

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Published

28-12-2018

How to Cite

B, Y. P. K., P. D, and V. A. M. “A PROSPECTIVE SINGLE-BLINDED STUDY ON THE SAFETY AND EFFICACY OF ZINC SUPPLEMENTATION IN PULMONARY TUBERCULOSIS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 16, Dec. 2018, pp. 90-94, doi:10.22159/ajpcr.2018.v11s4.31685.

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