A PROSPECTIVE SINGLE-BLINDED STUDY ON THE SAFETY AND EFFICACY OF ZINC SUPPLEMENTATION IN PULMONARY TUBERCULOSIS

Yeswanth Prasanna Kumar B; Praveen D; Vijey Aanandhi M

doi:10.22159/ajpcr.2018.v11s4.31685

Authors

Yeswanth Prasanna Kumar B Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Chennai, India.
Praveen D Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Chennai,India.
Vijey Aanandhi M Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Chennai, India

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s4.31685

Keywords:

Micronutrient, Pulmonary Tuberculosis, Zinc

Abstract

Aim and Objectives: The aim of the study was to study the serum zinc (Zn) levels, safety, and efficacy of Zn supplementation in pulmonary tuberculosis (PTB) patients.

Methods: A randomized single-blinded study of two groups: Group A received conventional TB therapy while Group B received conventional TB therapy along with 15 mg of Zn tablet. 40 patients were assigned in each group by randomized permuted blocks.

Results: After 8 weeks of treatment in Group A 27 patients and Group B 36 patients were found to be sputum negative with p=0.0421 and 0.0629. After 24 weeks of treatment in Group A 37 patients and Group B 40 patients were found to be sputum negative with p=0.00976 and 0.00971. By this, the given treatment was effective in the patients with PTB.

Conclusion: Zn supplementation improves the effect of TB medication treatment and results in earlier sputum smear conversion.

Downloads

Download data is not yet available.

References

World Health Organization. Implementing the WHO Stop TB Strategy:A Handbook for National TB Control Programmes. Geneva: World Health Organization; 2008. p. 179.

Fraker PJ, King LE. Reprogramming of the immune system during zinc deficiency. Ann Rev Nutr 2004;24:277-298.

Moynahan EJ. Zinc deficiency and cellular immunodeficiency in acrodermatitis enteropathicain man and zinc deficiency with

thymichypoplasiain fresian calves: A possible genetic link. Lancet 1977;2:1057-9.

Koyanagi A, Kullo D, Gresley L, Shenkin A, Cuevas LE. Relationships between serum concentrations of C-reactive protein and micronutrients in patients with tuberculosis. Ann Trop Med Parasitol 2004;98:391-400.

Wiid T, Seaman T, Hoal EG, Benade AJ, Van Helden PD. Total antioxidant levels are low during active TB and rise with anti-tuberculosis

therapy. IUBMB Life 2004;56:101-6.

Karyadi E, West CE, Schultink W, Nelwan RH, Gross R, Amin Z, et al. A double-blind, placebo-controlled study of Vitamin A and zinc

supplementation in persons with tuberculosis in Indonesia: Effects on clinical response and nutritional status. Am J Clin Nut2002;75:720-7.

Deveci F, Ilhan N. Plasma malondialdehyde and serum trace element concentrations in patients with active pulmonary tuberculosis. Biol Trace Elem Res 2003;95:29-38.

Lin X, Ding L, Wang Y, Yang Y. Determination of trace elements in serum of tuberculosis patients. Wei Sheng Yan Jiu 2000;29:395-6.

Milano A, Branzoni M, Canneva F, Profumo A, Riccardi G. The Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. Res Microbiol 2003;155:192-200.

Khanna BK, Kumar R, Mukerji PK, Chowdhury AR, Kamboh VP. Plasma copper and zinc levels in pulmonary tuberculosis. Ind J Tub

;29:179-84.

Karyadi E, Schultink W, Nelwan RH, Gross R, Amin Z, Dolmans WM, et al. Poor micronutrient status of active pulmonary tuberculosis patients in Indonesia. J Nutr 2000;130:2953-8.

Ghulam H, Kadri SM, Manzoor A, Waseem Q, Aatif MS, Khan GQ, et al. Status of zinc in pulmonary tuberculosis. J Infect Dev Ctries 2009;3:365-8.

Duzova H, Karagozler AA, Tekerekoglu MS, Emre MH. Serum zinc and copper levels in cases with Mycobacterium tuberculosis. Ege Tip Dergisi 2000;39:173-6.

Pakasi TA, Karyadi E, Wibowo Y, Simanjuntak Y, Suratih NM, Salean M, et al. Vitamin A deficiency and other factors associated with severe tuberculosis in Timor and Rote Islands, East Nusa Tenggara Province, Indonesia. Eur J Clin Nutr 2009;63:1130-5.

Brown KH. Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries. Am J Clin Nutr 1998;68 Supp l:425S-9.

Tuberculosis Research Centre, Madras, andW National Tuberculosis Institute, Bangalore. A controlled clinical trial of 3- and 5-month regimens in the treatment of sputum-positive pulmonary tuberculosis in South India. Am Rev Respir Dis 1986;134:27-33.

Crowle AJ, Ross EJ. Inhibition by retinoic acid of multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immune 1989;57:840-4.