EVALUATION OF IN VIVO IMMUNOMODULATORY ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACT OF CAPPARIS MOONII

VANITA G KANASE; SHRUTI SHETTIGAR

doi:10.22159/ajpcr.2020.v13i6.36031

Authors

VANITA G KANASE Department of ???, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.
SHRUTI SHETTIGAR Department of ???, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i6.36031

Keywords:

Capparis moonii, Carbon clearance, Ovalbumin antibody titer, Cyclophosphamide myelosuppression

Abstract

Objective: The present study was intended to evaluate the in vivo immunomodulatory activity of aqueous and ethanolic extract of dried fruits of Capparis moonii Wight.

Methods: The effect of both the extracts was evaluated by carbon clearance assay in mice, and they showed a significant increase in the phagocytic index at 50, 100, and 200 mg/kg dose. The effect of the extracts on delayed-type hypersensitivity (DTH) and antibody titer assay was evaluated in ovalbumin immunized mice.

Results: Both extracts showed a significant effect on DTH response and stimulation of antibody titer at 200 mg/kg dose. The effects of the extracts in cyclophosphamide-induced myelosuppression mice were also statistically significant.

Conclusion: The studies demonstrated specific and non-specific immunostimulating properties of both the ethanol and aqueous extract of C. moonii fruits in various in vivo experimental methods suggesting its therapeutic usefulness in immunocompromised conditions.

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Author Biography

VANITA G KANASE, Department of ???, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

HOD Pharmacology.

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