COMPARATIVE STUDY AGAINST OXIDATIVE STRESS AND DNA DAMAGE PROTECTION ACTIVITY OF THE DIFFERENT EXTRACTS OF TUBERS OF ARISAEMA TORTUOSUM (WALL.) SCHOTT.

PRIYANKA CHAKRABORTY; NRIPENDRA NATH BALA; SUDIPTA DAS

doi:10.22159/ajpcr.2020.v13i1.36284

Authors

PRIYANKA CHAKRABORTY Department of Pharmacology, BCDA College of Pharmacy and Technology, Barasat, Kolkata, West Bengal, India.
NRIPENDRA NATH BALA Department of Pharmacology, BCDA College of Pharmacy and Technology, Barasat, Kolkata, West Bengal, India.
SUDIPTA DAS Department of Pharmaceutics, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia, West Bengal, India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i1.36284

Keywords:

Antioxidant, DNA damage, Flavonoids, Phenolic compounds

Abstract

Objective: Our main aim is to evaluate the comparative in vitro antioxidant and DNA damage protection activity study with different extracts of tubers of Arisaema tortuosum.

Methods: A. tortuosum (Wall.) Schott. (Araceae family) is commonly known as whipcord cobra lily, used in India as traditional medicine. In vitro, antioxidant activity was done by six methods including determination of total phenolic and total flavonoid compounds. The DNA damage was estimated by standard diphenylamine reaction.

Results: Methanolic extract of tubers of A. tortuosum has been found rich in phenolic and flavonoid compounds when compared with other extracts. Methanolic extract of rhizomes of A. tortuosum showed potent antioxidant activity at a concentration of 400 μg/mL and potent the DNA damage protecting activity at a concentration of 50 μg/mL.

Conclusion: Comparative study against oxidative damage and protection to the DNA damage protection activity of the different extracts of tubers of A. tortuosum (Wall.) Schott. showed that methanolic extract is most potent, though ethyl acetate extract also showed activity.

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Author Biographies

NRIPENDRA NATH BALA, Department of Pharmacology, BCDA College of Pharmacy and Technology, Barasat, Kolkata, West Bengal, India.

Prof.(Dr.)Nripendra Nath Bala, Principal

SUDIPTA DAS, Department of Pharmaceutics, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia, West Bengal, India.

Assoc. Professor
B.Pharm., M.Pharm., PhD

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