KETOPROFEN-CARBOXYMETHYL CHITOSAN MICROPARTICLES PREPARED BY IONIC CROSSLINKING - SPRAY DRYING : OPTIMIZATION AND EVALUATION
Abstract
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Objective: The aim of this research was to investigate the effect of two operating parameters (inlet temperature and pump speed) of laboratory
spray dryer to optimize the production of ketoprofen-carboxymethyl chitosan (CM chitosan) microparticles and the effect of carboxymethyl chitosan
concentration on microparticles characteristics.
Methods: Microparticles with various concentration of CM chitosan were prepared by ionic gelation with CaCl2, then dried by spray drying with
various inlet temperature and pump speed. The obtained microparticles were evaluation for particle size, drug entrapment efficiency and drug
release.
Results: The results showed that inlet temperature at 100°C and pump speed at 9.0 ml/min was known to be the optimum condition since the drying
process was relatively faster and it could produce the most yield. The obtained CM chitosan microparticles have irregular and hollow shape with the
size of 1.1 – 2.1 μm. As carboxymethyl chitosan concentration increased, mean particle size and drug entrapment efficiency of the drugs increased.
In simulated intestinal fluid media pH 6.8, the release rate of ketoprofen from microparticles was delayed up to 0.43 times slower than ketoprofen
powder.
Conclusion: The optimal condition for spray drying in this study was at pump speed 9.0 ml/min with inlet temperature 100°C, since it gave the
most yield compare to other conditions. The size of ketoprofen-CM chitosan microparticles were between the range of 1.1 – 2.1 μm with high drug
entrapment. In general, microparticles of CM chitosan could delay ketoprofen release in simulated intestinal fluid media.
Keywords: Microparticles, Spray drying, Ketoprofen, Carboxymethyl chitosan.
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