STUDY OF HEPATOPROTECTIVE ACTIVITY OF STINGLESS BEE PROPOLIS AGAINTS TOXICITY OF DRUGS

MAHANI; GREGORIUS A O B; ENDAH WULANDARI; AHMAD SULAEMAN; HARDINSYAH; NUNUNG NURJANAH

doi:10.22159/ajpcr.2021.v14i12.43217

Authors

MAHANI Department of Food Technology, Faculty of Agric. Industrial Technology, Universitas Padjadjaran, Indonesia
GREGORIUS A O B Department of Food Technology, Faculty of Agric. Industrial Technology, Universitas Padjadjaran, Indonesia
ENDAH WULANDARI Department of Food Technology, Faculty of Agric. Industrial Technology, Universitas Padjadjaran, Indonesia
AHMAD SULAEMAN Department of Community Nutrition, Faculty of Human Ecology, IPB University, Indonesia.
HARDINSYAH Department of Community Nutrition, Faculty of Human Ecology, IPB University, Indonesia.
NUNUNG NURJANAH National Institute of Health Research and Development, Indonesian Ministry of Health Indonesia

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i12.43217

Keywords:

Antioxidant, Drug-induced liver injury, Hepatotoxic Hepatoprotective, Propolis

Abstract

Objective: The aim of this study is to determine the effect of stingless bee propolis supplementation as a hepatoprotector on the prevention of DILI and the effect of healing and restoring nutrition for DILI patients due to drug induction.

Methods: The literature review starts from problem identification, library data collection, reading, taking notes, analyzing, and processing the data obtained and then compiling it into a systematic review

Results: The results of a literature study conducted show that propolis has a good hepatoprotective ability against drugs that cause DILI cases such as the anti-tuberculosis, antibiotic and antipyretic groups as indicated by the SGPT, SGOT, BT, GSH, and SOD values that are close to normal values. In addition, propolis supplementation can accelerate the healing and restoration of the nutritional status of DILI patients. All active compounds contained in propolis such as phytochemicals and lipopolysaccharides work to protect the liver from the toxic effects of DILI through antioxidant mechanisms.

Conclusion: Overall, the data from this literature study show that the hepatoprotective activity of propolis has the potential to complement drug therapy to reduce hepatotoxic effects and can conclusively beneficial to accelerate the restoration of nutritional status for DILI patients.

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