LITERATURE REVIEW: ANTIDIABETIC ACTIVITY OF HONEY
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i4.44389Keywords:
Antioxidant, Antidiabetic, Type 2 Diabetes Mellitus, Hyperglycemia, HoneyAbstract
Objective: The aim of this study is to determine the antidiabetic activity of honey for people with Type 2 diabetes mellitus (T2DM) by looking at its effect on glycemic response, glycemic control, and its synergistic combination with antidiabetic drugs.
Methods: The literature review starts from problem identification, data collecting, sorting the obtained data, reading, and analyzing, finally, compiling it into a systematic review.
Results: The results show that honey has antidiabetic potential for people with T2DM as indicated by resulting good glycemic response and its combination with antidiabetic drugs results in positive glycemic control.
Conclusion: Honey possesses antidiabetic activity that could make it as an ideal supplementation for people with T2DM by helping them to achieve the ideal glycemic control and avoid further diabetic complications.
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References
International Diabetes Federation. IDF Diabetes Atlas. 9th ed. Brussels, Belgium: International Diabetes Federation; 2019.
Nahas R, Moher M. Complementary and alternative medicine for the treatment of type 2 diabetes. Can Fam Physician 2009;55:591-6. PMID 19509199
Erejuwa OO, Sulaiman SA, Wahab MS. Honey – A novel antidiabetic agent. Int J Biol Sci 2012;8:913-34. doi: 10.7150/ijbs.3697, PMID 22811614
Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for nutrition and health: A review. J Am Coll Nutr 2008;27:677-89. doi: 10.1080/07315724.2008.10719745, PMID 19155427
Brudzynski K, Sjaarda C. Antibacterial compounds of Canadian honeys target bacterial cell wall inducing phenotype changes, growth inhibition and cell lysis that resemble action of β-lactam antibiotics. PLoS One 2014;9:e106967. doi: 10.1371/journal.pone.0106967, PMID 25191847
Matzen RD, Zinck Leth-Espensen J, Jansson T, Nielsen DS, Lund MN, Matzen S. The antibacterial effect in vitro of honey derived from various Danish flora. Dermatol Res Pract 2018;2018:7021713. doi: 10.1155/2018/7021713, PMID 30018636
Watanabe K, Rahmasari R, Matsunaga A, Haruyama T, Kobayashi N. Anti-influenza viral effects of honey in vitro: Potent high activity of manuka honey. Arch Med Res 2014;45:359-65. doi: 10.1016/j. arcmed.2014.05.006, PMID 24880005
Charyasriwong S, Haruyama T, Kobayashi N. In vitro evaluation of the antiviral activity of methylglyoxal against influenza B virus infection. Drug Discov Ther 2016;10:201-10. doi: 10.5582/ddt.2016.01045, PMID 27558282
Fernandes L, Ribeiro H, Oliveira A, Sanches Silva A, Freitas A, Henriques M, et al. Portuguese honeys as antimicrobial agents against Candida species. J Tradit Complement Med 2021;11:130-6. doi: 10.1016/j.jtcme.2020.02.007, PMID 33728273
Moussa A, Noureddine D, Saad A, Abdelmelek M, Abdelkader B. Antifungal activity of four honeys of different types from Algeria against pathogenic yeast: Candida albicans and Rhodotorula sp. Asian Pac J Trop Biomed 2012;2:554-7. doi: 10.1016/S2221-1691(12)60096- 3, PMID 23569970
Hussein SZ, Mohd YK, Makpol S, Mohd YY. Gelam honey inhibits the production of proinflammatory, mediators NO, PGE 2, TNF-α, and IL-6 in carrageenan-induced acute paw edema in rats. Evid Based Complement Alternat Med 2012;2012:109636. doi: 10.1155/2012/109636
Sun LP, Shi FF, Zhang WW, Zhang ZH, Wang K. Antioxidant and anti-inflammatory activities of safflower (Carthamus tinctorius L.) honey extract. Foods 2020;9:E1039. doi: 10.3390/foods9081039, PMID 32748813
Fernandez-Cabezudo MJ, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, et al. Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model. PLoS One 2013;8:e55993. doi: 10.1371/journal.pone.0055993, PMID 23409104
Fauzi AN, Norazmi MN, Yaacob NS. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food Chem Toxicol 2011;49:871-8. doi: 10.1016/j.fct.2010.12.010, PMID 21167897
Wilczyńska A. Phenolic content and antioxidant activity of different types of polish honey – A short report. Pol J Food Nutr Sci 2010;60:309-13.
Erejuwa OO, Nwobodo NN, Akpan JL, Okorie UA, Ezeonu CT, Ezeokpo BC, et al. Nigerian honey ameliorates hyperglycemia and dyslipidemia in alloxan-induced diabetic rats. Nutrients 2016;8:95. doi: 10.3390/nu8030095, PMID 26927161
Ali H, Abu Bakar MF, Majid M, Muhammad N, Lim SY. In vitro anti-diabetic activity of stingless bee honey from different botanical origins. Food Res 2020;4:1421-6. doi: 10.26656/fr.2017.4(5).411
Triplitt CL. Examining the mechanisms of glucose regulation. Am J Manag Care 2012;18:S4-10. PMID 22559855
Vega-López S, Venn BJ, Slavin JL. Relevance of the glycemic index and glycemic load for body weight, diabetes, and cardiovascular disease. Nutrients 2018;10:E1361. doi: 10.3390/nu10101361, PMID 30249012
Deibert P, König D, Kloock B, Groenefeld M, Berg A. Glycaemic and insulinaemic properties of some German honey varieties. Eur J Clin Nutr 2010;64:762-4. doi: 10.1038/ejcn.2009.103, PMID 19756024
Ahmad A, Azim MK, Mesaik MA, Khan RA. Natural honey modulates physiological glycemic response compared to simulated honey and D-glucose. J Food Sci 2008;73:165-7. doi: 10.1111/j.1750- 3841.2008.00887.x
Münstedt K, Sheybani B, Hauenschild A, Brüggmann D, Bretzel RG, Winter D. Effects of basswood honey, honey-comparable glucose-fructose solution, and oral glucose tolerance test solution on serum insulin, glucose, and C-peptide concentrations in healthy subjects. J Med Food 2008;11:424-8. doi: 10.1089/jmf.2007.0608, PMID 18800887
Agrawal OP, Pachauri A, Yadav H, Urmila J, Goswamy HM, Chapperwal A, et al. Subjects with impaired glucose tolerance exhibit a high degree of tolerance to honey. J Med Food 2007;10:473-8. doi: 10.1089/jmf.2006.070, PMID 17887941
Al-waili NS. Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: Comparison with dextrose and sucrose. J Med Food 2004;7:100-7. doi: 10.1089/109662004322984789, PMID 1511756
Bender DA. Introduction to Nurtrition and Metabolism. 3rd ed. London: Taylor & Francis; 2004.
Merino B, Fernández-Díaz CM, Cózar-Castellano I, Perdomo G. Intestinal fructose and glucose metabolism in health and disease. Nutrients 2019;12:E94. doi: 10.3390/nu12010094, PMID 31905727
Erejuwa OO, Sulaiman SA, Wahab MS. Fructose might contribute to the hypoglycemic effect of honey. Molecules 2012;17:1900-15. doi: 10.3390/molecules17021900, PMID 22337138
El-Haskoury R, Al-Waili N, El-Hilaly J, Al-Waili W, Lyoussi B. Antioxidant, hypoglycemic, and hepatoprotective effect of aqueous and ethyl acetate extract of carob honey in streptozotocin-induced diabetic rats. Vet World 2019;12:1916-23. doi: 10.14202/ vetworld.2019.1916-1923, PMID 32095041
Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: Role of oxidative stress. Circulation 2002;106:2067-72. doi: 10.1161/01.CIR.0000034509.14906.AE, PMID 12379575
Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic Wistar-Kyoto rats and spontaneously hypertensive rats: Effects of antioxidant (honey) treatment. Int J Mol Sci 2011;12:1888-907. doi: 10.3390/ijms12031888, PMID 21673929
Aziz MS, Giribabu N, Rao PV, Salleh N. Pancreatoprotective effects of Geniotrigona thoracica stingless bee honey in streptozotocin-nicotinamide-induced male diabetic rats. Biomed Pharmacother 2017;89:135-45. doi: 10.1016/j.biopha.2017.02.026, PMID 28222394
Sahlan M, Rahmawati O, Pratami DK, Raffiudin R, Mukti RR, Hermasyah H. The Effects of stingless bee (Tetragonula biroi) honey on streptozotocin-induced diabetes mellitus in rats. Saudi J Biol Sci 2020;27:2025-30. doi: 10.1016/j.sjbs.2019.11.039
Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Parizadeh SM, Abasalti Z, Yaghoobi Z, et al. Natural honey and cardiovascular risk factors; effects on blood glucose, cholesterol, triacylglycerole, CRP, and body weight compared with sucrose. ScientificWorldJournal 2008;8:463-9. doi: 10.1100/tsw.2008.64, PMID 18454257
Al-Waili NS. Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals. J Med Food 2003;6:135-40. doi: 10.1089/109662003322233549, PMID 12935325
Farakla I, Koui E, Arditi J, Papageorgiou I, Bartzeliotou A, Papadopoulos GE, et al. Effect of honey on glucose and insulin concentrations in obese girls. Eur J Clin Invest 2019;49:e13042. doi: 10.1111/eci.13042
Rashid MR, Nor Aripin KN, Syed Mohideen FB, Baharom N, Omar K,Taujuddin NM, et al. The effect of Kelulut honey on fasting blood glucose and metabolic parameters in patients with impaired fasting glucose. J Nutr Metab 2019;2019:3176018. doi: 10.1155/2019/3176018, PMID 30863635
Bahrami M, Ataie-Jafari A, Hosseini S, Foruzanfar MH, Rahmani M, Pajouhi M. Effects of natural honey consumption in diabetic patients: An 8-week randomized clinical trial. Int J Food Sci Nutr 2009;60:618- 26. doi: 10.3109/09637480801990389, PMID 19817641
Sadeghi F, Salehi S, Kohanmoo A, Akhlaghi M. Effect of natural honey on glycemic control and anthropometric measures of patients with type 2 diabetes: A randomized controlled crossover trial. Int J Prev Med 2019;10:3. doi: 10.4103/ijpvm.IJPVM
Kwon EY, Jung UJ, Park T, Yun JW, Choi MS. Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity. Diabetes 2015;64:1658-69. doi: 10.2337/db14-0631, PMID 25524918
Abdulrhman MA. Honey as a sole treatment of type 2 diabetes mellitus. Endocrinol Metab Syndr 2016;05:???. doi: 10.4172/2161- 1017.1000232
Moher M. Diabetes mellitus. In: Integrative Medicine. 4th ed. Philadelphia, United States: Elsevier Inc.; 2018. p. 334-46.
Yale JF, Valiquett TR, Ghazzi MN, Owens-Grillo JK, Whitcomb RW, Foyt HL. The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. Am Soc Ann Intern Med 2001;134:737-45. doi: 10.7326/0003-4819-134-9_Part_1-200105010-00010, PMID 11329231
Erejuwa OO, Sulaiman SA, Wahab MS, Salam SK, Salleh MS, Gurtu S. Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats. Int J Mol Sci 2011;12:829-43. doi: 10.3390/ijms12010829, PMID 21340016
Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats. Int J Biol Sci 2011;7:244-52. doi: 10.7150/ijbs.7.244, PMID 21448302
Al Aamri ZM, Ali BH. Does honey have any salutary effect against streptozotocin – Induced diabetes in rats? J Diabetes Metab Disord 2017;16:4. doi: 10.1186/s40200-016-0278-y
Sirisha A, Gaur GS, Pal P, Bobby Z, Balakumar B, Pal GK. Effect of honey and insulin treatment on oxidative stress and nerve conduction in an experimental model of diabetic neuropathy Wistar rats. PLoS One 2021;16:e0245395. doi: 10.1371/journal.pone.0245395, PMID 33449943
Sameermahmood Z, Raji L, Saravanan T, Vaidya A, Mohan V, Muthuswamy B. Gallic acid Protects RINm5F B-cells from glucolipotoxicity by its antiapoptotic and insulin-secretagogue actions. Phyther Res 2008;22:544-9. doi: 10.1002/ptr
Punithavathi VR, Prince PS, Kumar R, Selvakumari J. Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats. Eur J Pharmacol 2011;650:465-71. doi: 10.1016/j.ejphar.2010.08.059, PMID 20863784
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