PREVALENCE AND ANTIMICROBIAL RESISTANCE IN ENTEROCOCCUS SPECIES
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i6.47283Keywords:
Enterococcus, Vancomycin-resistant Enterococci, PrevalenceAbstract
Objectives: The study was conducted to determine the prevalence of vancomycin-resistant Enterococci (VRE) isolated from various clinical samples received from the indoor patients of all age groups admitted in Government Medical College and Hospital, Amritsar.
Methods: A prospective cross-sectional study was conducted in the Department of Microbiology, Government Medical College, Amritsar, for a period of 4 years (July 1, 2018–June 30, 2022). All the samples (pus, urine, blood, body fluids, sputum, etc.) received from the indoor patients of all age groups admitted in Government Medical College and Hospital, Amritsar, were included in the study.
Results: During the study period of 4 years, among the culture positive samples, 1815 (6.62%) isolates were identified as Enterococcus species. Among 1815 isolates, 1089 isolates were Enterococcus faecalis (60%) and 726 were Enterococcus faecium (40%). Both E. faecalis and E. faecium isolates showed the maximum resistance to ciprofloxacin while linezolid, teicoplanin, and quinupristin/dalfopristin showed the maximum sensitivity.
Conclusion: Our study reports the prevalence of Enterococci isolates as well of VRE isolates. To reduce the VRE prevalence worldwide, appropriate use of antibiotics according to antimicrobial susceptibility testing should be encouraged. Efforts should be made to reduce the transmission of VRE isolates.
Downloads
References
Cetinkaya Y, Falk P, Mayhall CG. Vancomycin-resistant enterococci. Clin Microbiol Rev 2000;13:686-707. doi: 10.1128/CMR.13.4.686, PMID 11023964
Murray BE. The life and times of the Enterococcus. Clin Microbiol Rev 1990;3:46-65. doi: 10.1128/CMR.3.1.46, PMID 2404568
Revelas A. Healthcare-associated infections: A public health problem. Niger Med J 2012;53:59-64. doi: 10.4103/0300-1652.103543, PMID 23271847
Nautiyal S, Jauhari S, Joshi G, Kataria VK. Characterization of Enterococcus species in a tertiary care hospital. IOSRPHR 2016;6:48-51. doi: 10.9790/3013-068014851
Marothi YA, Agnihotri H, Dubey D. Enterococcal resistance--an overview. Indian J Med Microbiol 2005;23:214-9. doi: 10.1016/S0255- 0857(21)02524-X, PMID 16327115
Munita JM, Bayer AS, Arias CA. Evolving resistance among Gram-positive pathogens. Clin Infect Dis 2015;61 Suppl 2:S48-57. doi: 10.1093/cid/civ523, PMID 26316558
Kirschner C, Maquelin K, Pina P, Thi NA, Choo-Smith LP, Sockalingum GD, et al. Classification and identification of enterococci: A comparative phenotypic, genotypic, and vibrational spectroscopic study. J Clin Microbiol 2001;39:1763-70. doi: 10.1128/JCM.39.5.1763- 1770.2001, PMID 11325987
M100Ed32. Performance Standards for Antimicrobial Susceptibility Testing. 32nd ed. United States: Clinical and Laboratory Standards Institute.
Moghimbeigi A, Moghimbeygi M, Dousti M, Kiani F, Sayehmiri F, Sadeghifard N, et al. Prevalence of vancomycin resistance among isolates of enterococci in Iran: A systematic review and meta-analysis. Adolesc Health Med Ther 2018;9:177-88. doi: 10.2147/ AHMT.S180489, PMID 30532606
Melese A, Genet C, Andualem T. Prevalence of vancomycin resistant enterococci (VRE) in Ethiopia: A systematic review and meta-analysis. BMC Infect Dis 2020;20:124. doi: 10.1186/s12879-020-4833-2, PMID 32046668
Toru M, Beyene G, Kassa T, Gizachew Z, Howe R, Yeshitila B. Prevalence and phenotypic characterization of Enterococcus species isolated from clinical samples of pediatric patients in Jimma University Specialized Hospital, South West Ethiopia. BMC Res Notes 2018;11:281.
Hirak D, Raj J, Das D, Mondal S. Prevalence of enterococcal infection and the antimicrobial susceptibility profile of the organism with special reference to vancomycin: A study in a rural medical College Hospital in Eastern India. IOSR J Dent Med Sci 2019;18:9-15.
Boccella M, Santella B, Pagliano P, De Filippis A, Casolaro V, Galdiero M, et al. Prevalence and antimicrobial resistance of Enterococcus species: A retrospective cohort study in Italy. Antibiotics (Basel) 2021;10:1552. doi: 10.3390/antibiotics10121552, PMID 34943764
Salem-Bekhit MM, Moussa IM, Muharram MM, Alanazy FK, Hefni HM. Prevalence and antimicrobial resistance pattern of multidrug-resistant enterococci isolated from clinical specimens. Indian J Med Microbiol 2012;30:44-51. doi: 10.4103/0255-0857.93032, PMID 22361760
Bhatt P, Patel A, Sahni AK, Praharaj AK, Grover N, Chaudhari CN, et al. Emergence of multidrug resistant enterococci at a tertiary care centre. Med J Armed Forces India 2015;71:139-44. doi: 10.1016/j. mjafi.2014.08.007, PMID 25859076
Higuita NI, Huycke MM. Enterococcal disease, epidemiology, and implications for treatment. In: Enterococci Commensals Leading Causes Drug Resistant Infection. Boston: Massachusetts Eye and Ear Infirmary; 2014.
Arif D, Tripathi A, Srivastava P, Singh SP, Bisht D. Prevalence of vancomycin resistant Enterococcus in various clinical specimens in tertiary Care Hospital. Int J Health Sci 2019;4:5.
Mathur P, Kapil A, Chandra R, Sharma P, Das B. Antimicrobial resistance in Enterococcus faecalis at a tertiary care centre of northern India. Indian J Med Res 2003;118:25-8. PMID 14748462
Nisarta A. Study of antimicrobial resistance in enterococci at Government Medical College, Bhavnagar, Gujarat, India. Int J Curr Microbiol Appl Sci 2016;5:826-36. doi: 10.20546/ijcmas.2016.509.093
Shrestha S, Kharel S, Homagain S, Aryal R, Mishra SK. Prevalence of vancomycin‐resistant enterococci in Asia-A systematic review and meta-analysis. J Clin Pharm Ther 2021;46:1226-37. doi: 10.1111/ jcpt.13383, PMID 33630382
Mukherjee K, Bhattacharjee D, Chakraborti G. Prevalence and antibiotic susceptibility pattern of Enterococcus species from various clinical samples in a Tertiary Care Hospital in Kolkata. Int J Contemp Med Res 2016;3:3.
Chitnis S, Katara G, Hemvani N, Pareek S, Chitnis DS. In vitro activity of daptomycin & linezolid against methicillin resistant Staphylococcus aureus & vancomycin resistant enterococci isolated from hospitalized cases in Central India. Indian J Med Res 2013;137:191-6. PMID 23481072
Klare I, Witte W, Wendt C, Werner G. Vancomycin-resistente enterokokken (VRE). Recent results and trends in development of antibiotic resistance. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2012;55:1387-400.
Published
How to Cite
Issue
Section
Copyright (c) 2023 SANIYA OHRI SANIYA
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.