CLINICAL AND ETIOLOGICAL PROFILE OF PATIENTS PRESENTING WITH ASCITES IN A TERTIARY CARE HOSPITAL
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i7.47489Keywords:
Ascites, Peritoneal cavity, Cirrhosis of liver, NASH (Nonalcoholic steatohepatitis)Abstract
Objectives: Ascites is one of the common clinical problems confronting a physician, with a myriad of causes behind. Early detection and evaluation of the causes of ascites help in effective management and lessens complications. However, there is lack of data regarding the prevalence of causes of ascites in our set-up. Hence, this study was conducted in our tertiary care hospital to study the clinical profiles and etiological factors of patients with ascites.
Methods: This prospective and observational study was carried out in the Department of General Medicine of S.C.B. Medical College and hospital, Cuttack, Odisha, India, from September 2019 to November 2021. Hundred patients of ascites of either sex >18 years of age admitted in the medicine ward fulfilling the inclusion and exclusion criteria were included in this study and were thoroughly evaluated after obtaining informed consent. All the patients were subjected to detailed history taking, thorough physical examination and routine laboratory evaluation such as complete blood count, random blood sugar, liver function test, renal function test, serum protein and albumin, serum electrolytes, prothrombin time, international standardized ratio, hepatitis B surface antigen, and antibody to hepatitis C. Hepatic encephalopathy, when present, was classified into four grades according to West Haven criteria. Ultrasonography of abdomen and pelvis, Digital chest X-ray PA view, and ECG were done in all the patients.
Results: In the present study of 100 patients, major cause of ascites was found to be cirrhosis of liver (64%) followed by tuberculosis (10%), malignancy (9%), heart disease (7%), and nephrotic syndrome (3%). The major cause of the cirrhosis of liver was alcoholism (64%) followed by hepatitis B (15.6%), Non-alcoholic steatohepatitis (14.1%), Hepatitis C (4.7%), and cryptogenic (3.1%). Complications such as hepatic encephalopathy and spontaneous bacterial peritonitis were observed in 17% and 7.8% cases of ascites, respectively.
Conclusion: Cirrhosis of liver was found to be the most common cause of ascites in our study followed by tuberculosis and malignancy. Alcoholism was the most common cause of cirrhosis followed by chronic hepatitis B.
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References
Rudralingam V, Footitt C, Layton B. Ascites matters. Ultrasound 2017;25:69-79. doi: 10.1177/1742271X16680653, PMID 28567101
Hernaez R, Hamilton JP. Unexplained ascites. Clin Liver Dis (Hoboken) 2016;7:53-6. doi: 10.1002/cld.537, PMID 31041029
Chiejina M, Kudaravalli P, Samant H. Ascites. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2021. Available from: www.ncbi.
nlm.nih.gov/books/NBK470482/ [Last accessed on 2021 Aug 11]
Moore KP, Aithal GP. Guidelines on the management of ascites in cirrhosis. Gut 2006;55(Suppl 6):vi1-12. doi: 10.1136/gut.2006.099580, PMID 16966752
Corey KE, Friedman LS. Abdominal swelling and ascites. In: Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J, editors. Harrison’s Principles of Internal Medicine. Vol. 20. United States: McGraw Hill; 2018. p. 281-5.
D’Amico G, Garcia-Tsao G, Pagliaro LL. Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies. J Hepatol 2006;44:217-31. doi: 10.1016/j.jhep.2005.10.013, PMID 16298014
Garrison RN, Kaelin LD, Galloway RH, Heuser LS. Malignant ascites. Clinical and experimental observations. Ann Surg 1986;203:644-51. doi: 10.1097/00000658-198606000-00009, PMID 3718029
Mehra D, Thakur D, Agarwal G, Kumar A, Sultania S, Chaturvedi A. Etiology of ascites in adults living in Rohilkhand region, India: A hospital-based study. Int J Appl Res 2016;2:1-4.
Muhie OA. Causes and clinical profiles of ascites at university of Gondar hospital, Northwest Ethiopia: Institution-based cross-sectional study. Can J Gastroenterol Hepatol 2019;2019:5958032. doi: 10.1155/2019/5958032, PMID 31360695
Joshi R, Shrestha DB, Pande R, Maharjan S. Clinical profile of ascites based on presentation and laboratory findings: An institutional experience from Kathmandu, Nepal. J Med Res Innov 2018;2:e000101. doi: 10.15419/jmri.101
Khan FY. Ascites in the state of Qatar: Aetiology and diagnostic value of ascitic fluid analysis. Singapore Med J 2007;48:434-9. PMID 17453102
Kumar B, Sharma B, Raina S, Sharma N, Gupta D, Mardi K. Etiology of ascites in adults living in the Hills of Himachal Pradesh, India: A hospital-based study. CHRISMED J Heal Res 2016;3:41. doi: 10.4103/2348-3334.172398
Tsega E. Laparoscopic evaluation of ascites and other abdominal conditions in Ethiopia. Trop Geogr Med 1989;41:341-5.
Malabu UH, Olubuyide IO, Shaibu ME, Olawuyi F. Ascites in Ibadan, Nigeria-usefulness of albumin gradient in its etiologic diagnosis. Biomed Res 2006;17:105-9.
Hwangbo Y, Jung JH, Shim J, Kim BH, Jung SH, Lee CK, et al. Etiologic and laboratory analyses of ascites in patients who underwent diagnostic paracentesis. Korean J Hepatol 2007;13:185-95. PMID 17585192
Tasneem H, Shahbaz H, Sherazi BA. Pharmacoepidemiology of ascites and associated complications in hospitalized patients: Descriptive observational study. Int Curr Pharm J 2015;4:343-6. doi: 10.3329/icpj. v4i2.21482
Akriviadis EA, Runyon BA. Utility of an algorithm in differentiating spontaneous from secondary bacterial peritonitis. Gastroenterology 1990;98:127-33. doi: 10.1016/0016-5085(90)91300-u, PMID 2293571
Krastev N, Djurkov V, Murdjeva M, Akrabova P, Karparova T, Penkov V, et al. Diagnosis of spontaneous and secondary bacterial peritonitis in patients with hepatic cirrhosis and ascites. Khirurgiia (Sofiia) 2013;2:20-5. PMID 24459763
Tarn AC, Lapworth R. Biochemical analysis of ascitic (peritoneal) fluid: What should we measure? Ann Clin Biochem 2010;47:397-407. doi: 10.1258/acb.2010.010048, PMID 20595402
Runyon BA. Amylase levels in ascitic fluid. J Clin Gastroenterol 1987;9:172-4. doi: 10.1097/00004836-198704000-00012, PMID 2437177
DiBonito L, Falconieri G, Colautti I, Bonifacio D, Dudine S. The positive peritoneal effusion. A retrospective study of cytopathologic diagnoses with autopsy confirmation. Acta Cytol 1993;37:483-8. PMID 8328242
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