COST ANALYSIS OF BRANDED VERSUS GENERIC ANTI-DIABETIC DRUGS USED FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL

SARANNYA RAVI; LIYA ROSLIN JOSEPH; SREELAKSHMI VENUGOPAL

doi:10.22159/ajpcr.2024v17i9.51620

Authors

SARANNYA RAVI Department of Pharmacology, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India. https://orcid.org/0009-0004-9826-4860
LIYA ROSLIN JOSEPH Department of Pharmacology, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India. https://orcid.org/0000-0003-2757-1295
SREELAKSHMI VENUGOPAL Department of Pharmacology, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India.

DOI:

https://doi.org/10.22159/ajpcr.2024v17i9.51620

Keywords:

Anti-diabetic drugs, Cost analysis, Generic drugs, Branded drugs

Abstract

Objectives: This study aims to assess the percentage cost variation among branded anti-diabetic drugs prescribed in a tertiary care hospital with its generic equivalent.

Methods: A cross-sectional study was performed in a tertiary care hospital among 51 diabetic patients attending the endocrinology outpatient department. Demographic data and details of anti-diabetic drugs prescribed were collected from case sheets. Costs of branded anti-diabetic drugs were obtained from the current index of medical specialties April–July 2023 and their generic equivalents from Janaushadhi price list 2023. The percentage cost variation of these drugs per prescription was determined.

Results: The mean age of the patients included in the study was 58.12, with 23 male and 28 female participants. Thirty-eight (74.5%) prescriptions contained oral hypoglycemic agent (OHA) alone, and 12 (23.54%) contained insulin and OHA. Metformin–glimepiride combination was the most common drug prescribed. The mean cost of the branded anti-diabetic drugs per prescription per day was 28.15±13.85 and the estimated mean cost of their generic equivalent was 12.10±6.68. A 135.61% cost variation was observed for the antidiabetic drug prescriptions studied.

Conclusion: In this study, it was observed that there is a significant cost variation among branded and generic anti-diabetic drugs.

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References

Sun H, Saeedi P, Karuranga S, Pinkepank M, Duncan BB, Stein C, et al. IDF diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022 Jan 1;183:109119.

International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels, Belgium: International Diabetes Federation; 2021.

U.S. Food and Drug Administration. Generic Drug Facts. U.S. FDA. Available from: https://www.fda.gov/drugs/generic-drugs/generic-drugs-facts [Last assessed on 2024 May 18].

Jan Aushadhi. Pradhan Mantri Jan Aushadhi Yojana (PMJY). Available from: https://janaushadhi.gov.in/pmjy.aspx [Last assessed on 2024 May 18].

Chaudhary RK, Philip MJ, Santhosh A, Karoli SS, Bhandari R, Ganachari MS. Health economics and effectiveness analysis of generic anti-diabetic medication from Jan Aushadhi: An ambispective study in community pharmacy. Diabetes Metab Syndr. 2021;15(6):102303.

CIMS Editorial Board. CIMS April-July. 2023th ed. Mumbai: CIMS Medica India Pvt Ltd.; 2023. p.345-361.

Chaudhary GM, Chaudhary FM, Tanveer A, Tameez Ud Din A, Chaudhary SM, Shafi A. Demographic and clinical characteristics of 4556 type 2 diabetes mellitus patients at a tertiary care hospital in Southern Punjab. Cureus. 2019 May 3;11(5):e4592.

Mahmood M, Reddy RC, Lahari JR, Fathima S, Shinde P, Reddy SA, et al. Prescription pattern analysis of antidiabetic drugs in diabetes mellitus and associated comorbidities. J Clin Investig. 2017 Nov 17;8(1):5-11.

Vengurlekar S, Shukls P, Patidar P, Bafna R, Jain S. Prescribing pattern of antidiabetic drugs in Indore city hospital. Indian J Pharm Sci. 2008 Sep;70(5):637-40.

Goyal PK, Arora S, Mittal N, Mahajan B, Kaushal S. Prescribing pattern and pharmacoeconomic analysis of antidiabetic drugs. Int J Basic Clin Pharmacol. 2019 Jul 23;8(8):1844-9.

Kiran PG, Anil SP, Karmur M. Prescription pattern and cost variation analysis in type 2 diabetes mellitus patients at private outpatient department. Int J Basic Clin Pharmacol. 2021 Jul;12(3):11-4.

Agarwal AA, Jadhav PR, Deshmukh YA. Prescribing pattern and efficacy of anti-diabetic drugs in maintaining optimal glycemic levels in diabetic patients. J Basic Clin Pharm. 2014 Jun;5(3):79-83. 13. Pushpa VH, Nagesh HN, Ramesh HS. Study on prescribing pattern and rational use of antidiabetic drugs in elderly patients with type 2 diabetes mellitus in tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2020 Jun 23;10(10):825-6.

Tiwari K, Bisht M, Kant R, Handu SS. Prescribing pattern of anti-diabetic drugs adherence to the American Diabetes Association’s (ADA) 2021 treatment guidelines among patients of type 2 diabetes mellitus: A cross-sectional study. J Family Med Prim Care. 2022 Oct;11(10):6159-64.

Singh A, Dutta SB, Varma A, Beg MA, Kumar H, Kaut A. A drug utilization and pharmacoeconomic study of anti-diabetic drugs prescribed to type 2 diabetes mellitus patients visiting the medicine out-patient department of a tertiary care hospital of North India. Int J Basic Clin Pharmacol. 2016 Jan 5;5(4):1220-7.

Priyanka B, Thirunavukkarasu J, Sreenivasan V. Evaluate the prescription pattern of anti-diabetic patients attending medicine out-patient department of a tertiary care hospital. World J Pharm Sci. 2019 Sep 2;7(9):137-43.

Sultana G, Kapur P, Aquil M, Alam MS, Pillai KK. Drug utilization of oral hypoglycemic agents in a university teaching hospital in India. J Clin Pharm Ther. 2010 Jun;35(3):267-77.

Das AK, Dutta A, Maity A, Sarkar DK, Nandy M, Ghosh J. Prescribing pattern of antidiabetic drugs in type 2 diabetes mellitus at a tertiary care hospital in Eastern India. Int J Community Med Public Health. 2021 Jan;8(2):721-6.

American Diabetes Association Professional Practice Committee. 9. Pharmacologic approaches to glycaemic treatment: Standards of care in Diabetes-2024. Diabetes Care. 2024 Jan 1;47 Suppl 1:S158-78.

Acharya KG, Shah KN, Solanki ND, Rana DA. Evaluation of antidiabetic prescriptions, cost and adherence to treatment guidelines: A prospective, cross-sectional study at a tertiary care teaching hospital. J Basic Clin Pharm. 2013 Sep;4(4):82-7.

Yuvanesh P, Geetha P. Cost comparison between branded medicines and Jan Aushadhi medicines. Ann RSCB. 2021 Apr 3;25(4):18352-9.

Mohith M, Nalini GK, Deepak P, Sahana GN, Nagaral JV, Rakshitha BV, et al. Analysis of cost between branded medicines and generic medicines in a tertiary care hospital. Int J Basic Clin Pharmacol. 2019 May;8(5):1074-7.