EVALUATION OF DIURETIC ACTIVITY OF PICRIA FEL-TERRAE LOUR LEAVES EXTRACTS

Authors

  • Aminah Dalimunthe Faculty of Pharmacy, University of Sumatera Utara
  • Urip Harahap
  • Rosidah .
  • Pandapotan Nasution M

Abstract

Objective: The aims of this study was to evaluate the diuretic activity of different leaves extract of Picria fel-terrae using n-hexane, ethylacetate and ethanol as solvents.

 

Methods: The diuretic activity of the extracts were evaluated by determining urine volume and electrolyte (Na+, K+) concentration in male Wistar rats at a various dose extract of  400 and 800 mg/kg bw. Furosemide (10 mg/kb bw) was used as reference drug and cmc-Na 1% was as normal control.

 

Results: Urine volume was significan increase by n-hexane extract at dose 800 mg/kg bw in comparison to normal control groups. The excretion of sodium was also increase by the all extract. The n-hexane extract showed better diuretic effect in comparison to other extract.

 

Conclusion: The leaves extracts of Picria fel-terrae have diuretic activity

 

Keyword: Picria fel-terrae Lour, diuresis, urine electrolyte

 

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References

REFERENCES

Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo ZG. Medicinal plants in therapy. In: The Bulletin of The World Health Organization. Geneva: WHO; 1985. p. 83-97.

Nayak BS, Dinda SC, Ellaiah P. Evaluation of diuretic activity of gmelina arborea roxb. Fruit extracts. Asian J Pharm Clin Res 2013;6 Suppl 1:111-3.

Dutta KN, Chetia P, Lahkar S, Das S. Herbal plants used as diuretics: A comprehensive review. J Pharm Chem Biol Sci 2014;2(1):27-32.

Huang Y, Cimanga K, Lasure A, Van Poel B, Pieters L, Berghe-Vanden D, et al. Biological activities of picria fel-terrae Lour. Pharm World Sci Suppl 1994;16(6):18.

Thuan ND, Ha do T, Thuong PT, Na MK, Lee JP, Lee JH, et al. A phenylpropanoid glycoside with antioxidant activity from Picria tel-ferae. Arch Pharm Res 2007;30(9):1062-6.

Sitorus P, Harahap U, Pandapotan M, Barus T. Isolation of β-sitosterol from n-hexane extract of picria fel-terrae lour. Leave and study of its antidiabetic effect in alloxan induced diabetic mice. Int J Pharm Tech Res 2014;6(1):137-41.

OECD 420. Guideline for Testing of Chemicals: Acute Oral Toxicity-Fixed Dose Procedure. Paris: OECD; 2001.

Asif M, Atif M, Malik AS, Dan ZC, Ahmad I, Ahmad A. Diuretic activity of trianthema portulacastrum crude extract in albino rats. Trop J Pharm Res 2013;12(6):967-72.

Sood AR, Bajpai A, Digits M. Pharmacological and biological studies on saponins. Indian J Pharm 1985;17(3):178-9.

Rizvi SH, Shoeb A, Kapil RS, Satya PP. Two diuretic triterpenoids from Antiderma menasu. Phytochemistry 1980;19(11):2409-10.

Chodera A, Dabrowska K, Sloderbach A, Skrzypczak L, Budzianowski J. Effect of flavonoid fractions of Solidago virgaurea L on diuresis and levels of electrolytes. Acta Pol Pharm 1991;48(5-6):35‑7.

Patel U, Kulkarni M, Undale V, Bhosale A. Evaluation of diuretic activity of aqueous and methanol extracts of lepidium sativum garden cress (cruciferae) in rats. Trop J Pharm Res 2009;8(3):215-9.

Published

01-07-2015

How to Cite

Dalimunthe, A., U. Harahap, R. ., and P. Nasution M. “EVALUATION OF DIURETIC ACTIVITY OF PICRIA FEL-TERRAE LOUR LEAVES EXTRACTS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 4, July 2015, pp. 204-5, https://journals.innovareacademics.in/index.php/ajpcr/article/view/6405.

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