FORMULATION DEVELOPMENT, EVALUATION AND OPTIMIZATION OF MEDICATED LIP ROUGE CONTAINING NIOSOMAL ACYCLOVIR FOR THE MANAGEMENT OF RECURRENT HERPES LABIALIS
DOI:
https://doi.org/10.22159/ijap.2017v9i6.19349Keywords:
Acyclovir, Niosomes, Herpes Labialis, Lip, CosmeticsAbstract
Objective: Aim of the study was to formulate, evaluate and optimize medicated Lip rouge containing acyclovir encapsulated inside a novel vesicular carrier, niosome so that the formulation can improve its membrane penetration. Formulating as a cosmetic Lip rouge formulation will also improve patient compliance in the treatment of herpes labialis.
Methods: Acyclovir niosomes were prepared by thin film hydration method. Niosomes were evaluated and were optimized by considering the entrapment efficiency and in vitro release profile. The optimized niosomes were incorporated into lipstick, lip balm and lip rouge for selecting the best lip formulation. Based on the in vitro release profile, ease of application and properties of prepared formulations lip rouge was selected and further evaluations were carried out.
Results: Among the six formulations of niosomes NF2 has showed 88.49 % entrapment efficiency and 86.97% cumulative drug release in 8 h. The formulation was optimized considering both entrapment efficiency and in vitro release. The optimized formulation of niosomes was incorporated into Lipstick, lip balm and lip rouge. The evaluation results of lipstick, lip balm and lip rouge for in vitro release suggested lip rouge as the best formulation. The percentage cumulative release of drug from optimized lip rouge at the end of 8 h was 84.77%. The percentage cumulative drug release in ex vivo studies for 8 h was 60.88 %.
Conclusion: The results suggested that prepared lip rouge containing acyclovir niosomes can effectively deliver the drug than the marketed acyclovir cream and successful therapy of Recurrent Herpes labialis can be achieved.
Downloads
References
Madhav Satheesh, NV Ojha A. Labial mucosa as a novel transmucosal drug delivery platform. Int J Pharm Pharm Sci 2012;4:83-90.
Sharma PP. Cosmetics, formulation, manufacture and quality control. Lipsticks. 4th ed. Delhi: Vandana Publications; 2008.
Lakshmi PKD Prasanthi. Vesicles: mechanism of transdermal permeation a review. Asian J Pharm Clin Res 2012;5:18-25.
Saroj Soumya, BA Doney, M Sabitha. Current trends in lipid based delivery systems and its applications in drug delivery. Asian J Pharm Clin Res 2012;3:4-9.
Kushal AM, Pragna SK. Formulation and development of topical niosomal gel of BCS class III antiviral drug for better efficacy as herpes treatment. Int J Res Papers 2012;3:271-5.
Indian Pharmacopoeia. 7th ed. Ghaziabad: Government of India; Indian pharmacopoeia commission; 2014.
Ankarao A, Sowjanya CH, Seetha Devi A, Naik VV, Rajesh A. Formulation and evaluation of niosomes of valacyclovir hydrochloride. Int J Curr Trends Pharm Res 2015;3:794–800.
Abdelhalem Ali AM, Sarhan HA, Magdy T. Preparation and characterization of phenytoin sodium niosomes for the enhanced closure of skin injuries. Int J Pharm Pharm Sci 2014;6:542-6.
Suresh RV, Kerunath KP. Formulation and evaluation of novel antibacterial ciprofloxacin loaded niosomal cream. Int Res J Pharm 2015;6:519-27.
Sathish S, Mahesh Ch, Saikat Das, Lavanya V, Suresh B. Preparation and evaluation of salicylic acid medicated lipstick. J Appl Pharm Sci 2012;2:289-94.
Mishra P, Dwivedi S. Formulation and evaluation of lipstick containing herbal ingredients. Asian J Med Pharm Res 2012;2:58-60.
Yadav P, Nanda S. Development and evaluation of some microsponge loaded medicated topical formulations of acyclovir. Int J Pharma Sci Res 2014;5:1395-410.
Kar K, Sudheer P. Formulation and evaluation of niosomal drug delivery system of ketoprofen. J Pharm Sci 2015;5:173-80.
Satheesh Madhav NV, Yadav AP. Design and evaluation of novel rosiglitazone loaded bio lip-strips using novel biomaterial for systemic delivery through a novelistic translabial route. Indo Am J Pharm Res 2014;4:3000-10.
Khan MA, Ghabeish MA, Yang Y. Influence of drug loading and type of ointment base on the in vitro performance of acyclovir ophthalmic ointment. Int J Pharm 2015; 495:783–91.
Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes-novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Controlled Release 2000;65:403-18.
Patravale VB, Mandawgade SD. Novel cosmetic delivery systems: an application update. Int J Cosmet Sci 2008;30:19–33.
Lingan MA, Sathali AH. Formulation and evaluation of topical drug delivery system containing clobetasol propionate niosomes. Sci Rev Chem Commun 2011;1:7-17.
Ruckmani K, Jayakar B, Ghosal SK. Nonionic surfactant vesicles (niosomes) of cytarabine hydrochloride for effective treatment of leukemias: encapsulation, storage, and in vitro release. Drug Dev Ind Pharm 2000;26:217-22.
Devaraj GN, Parakh SR, Devraj R, Apte SS, Rao BR, Rambhau D. Release studies on niosomes containing fatty alcohols as bilayer stabilizers instead of cholesterol. J Colloid Interface Sci 2002;251:360–5.
Published
How to Cite
Issue
Section
