DEVELOPMENT AND EVALUATION OF TIOCONAZOLE LOADED EMULGEL
DOI:
https://doi.org/10.22159/ijap.2017v9i5.20046Keywords:
Emulgel, Tioconazole, Hydrophobic drug, Topical drug deliveryAbstract
Objective: The objective of the present work was to develop, characterize and evaluate the tioconazole loaded emulgel and to prove that emulgel can be the best alternative for delivery of hydrophobic drug topically.
Methods: for the preparation of stable Emulgel, firstly gels were prepared using different polymers as carbopol 934 and xanthan gum, followed by preparation of emulsions and finally mixed together (table 1). Emulgel was evaluated for physical appearance, pH, spreadability, extrudability, viscosity, swelling index, dilution test, centrifuge test, drug content, in vitro release study, kinetic analysis of release data, antifungal activity and stability study for 3 mo. A comparative study was also performed between prepared emulgels with available marketed antifungal cream.
Results: All evaluation parameters were in acceptable range with good physical appearance and the pH in the range of 5.5 to 6.8. The results show that the extrudability was in the range 15.63 to 35.27 g/cm2; with spreadability in range of 6.6 to 8.833 cm. swelling index of F3 was seen a maximum in 3 h of about 75.13%. The viscosity was in the range of 15240 to 56340 cps at 10 RPM. During in vitro release of all formulations, F1 and F5 showed a maximum in vitro drug release of 59.11% and 55.11% respectively in 8 h. The kinetic analysis of fitting the data in different model shows that the best formulation of F1 fits in the Higuchi model with regression coefficient (R2) of 0.998 and show non-fickian diffusion. The formulations were found stable. F1 and F5 provide a similar zone of inhibition like to market cream.
Conclusion: Tioconazole emulgel provide the better platform for delivery of hydrophobic drug for topical route and so able to produce better patient compliance.Â
Downloads
References
Ambala R, Vemula SK. Formulation and characterization of ketoprofen emulgels. J Appl Pharm Sci 2015;5:112-7.
Pednekar A, Dandagi P, Gadad A, Mastiholimath V. Formulation and characterisation of meloxicam loaded emulgel for topical application. Int J Pharm Pharm Sci 2015;7:216-22.
Ajazuddin, Alexander A, Khichariya A, Gupta S, Patel RJ, Giri TK, et al. Recent expansions in an emergent novel drug delivery technology: emulgel. J Controlled Release 2013;171:122-32.
Tripathi KD. Essentials of medical pharmacology. 6th ed. New Delhi: Jaypee publishers; 2008.
Clissold SP, Heel RC. Tioconazole a review of its antimicrobial activity and therapeutic use in superficial mycoses. Drugs 1986;31:29-51.
Rathnanand M, Khatri SK, Nikhila R. Formulation and evaluation of wound healing activity of linezolid topical preparations on diabetic rats. Int J Appl Pharm 2016;8:30-6.
Mohamed MI. Optimization of chlorphenesin emulgel formulation. AAPS J 2004;6:1-7.
Kumar V, Antil M, Singh J, Kumar D. Emulgel-novel topical drug delivery system–a comprehensive review. Int J Pharm Sci Res 2016;7:4733-42.
Khan WA, Kotta S, Ansari SA, Sharma RK, Kumar A, Ali J. Formulation development, optimization and evaluation of aloe vera gel for wound healing. Pharmacogn Mag 2013;9:6-10.
Khambete H, Deveda P, Jain A, Vyas N, Jai S. Gellified emulsion for sustain delivery of itraconazole for topical fungal diseases. Int J Pharm Pharm Sci 2010;2:104-12.
Ashara KC, Paun JS, Soniwala MM, Chavada JR, Mori NM. Micro-emulsion based emulgel: a novel topical drug delivery system. Asian Pac J Trop Dis 2014;4:27-32.
Kundan PJ, Laxman DS, Eknath PK. Stability evaluation of topical ointment comprising calcipotriol and prednicarbate. Int Res J Pharm 2015;6:43-7.
Sundari PP, Mullapudi D, Srinivas P. Formulation and evaluation of anti-arthritic poly herbal emulgel. Int J Pharm Technol 2014;6:6608-21.
Saxena A, Singh R. A review on levofloxacin in situ-gel formulation. Asian J Pharm Clin Res 2015;8:37-41.
Ali-Shtayeh MS, Abu Ghdeib SI. Antifungal activity of plant extracts against dermatophytes. Mycoses 1999;42:665–72.
Mulye SP, Wadkar KA, Kondawar MS. Formulation development and evaluation of Indomethacin emulgel. Pharm Sinica 2013;4:31-45.
Ghodekar SV, Chaudhari SP, Ratnaparakhi MP. Development and characterization of silver sulfadiazine emulgel for topical drug delivery. Int J Pharm Pharm Sci 2012;4:305-16.
