FORMULATION AND PHYSICAL STABILITY TEST OF GRISEOFULVIN MICROEMULSION GEL
DOI:
https://doi.org/10.22159/ijap.2017.v9s1.22_27Keywords:
Griseofulvin, Surfactant, Microemulsion gel, Physical stability, FormulationAbstract
Objective: The main objective of this research is to make and evaluate the formulation of a griseofulvin microemulsion gel for topical use to increase
the solubility and safety of the drug.
Methods: The optimized microemulsion formula contains 5% oleic acid as the oil phase, 25% Tween 80 as the surfactant, and 20% ethanol (96%)
as the cosurfactant.
Results: Organoleptic observations of the microemulsion showed that it had a clear and transparent yellowish color, while the microemulsion gel had
a hazy yellowish color. Both the microemulsion and the microemulsion gel had the smell of alcohol. The size of the globules in the microemulsion and
the microemulsion gel was 158.0 nm and 226.0, respectively.
Conclusions: The griseofulvin microemulsion gel was stable at 4°C±2°C, 25°C±2°C, and 40°C±2°C.
Downloads
References
International Agency for Research on Cancer. IARC Monographs
on the Evaluation of Carcinogenic Risks to Humans. Vol. 79. Lyon,
France: IARC Press; 2001. p. 75-89.
Tanaka Y, Waki R, Nagata S. Species differences in the dissolution
and absorption of griseofulvin and albendazole, biopharmaceutics
classification system class II drugs, in the gastrointestinal tract. Drug
Metab Pharmacokinet 2013;28(6):485-90.
Aggarwal N, Goindi S, Khurana R. Formulation, characterization and
evaluation of an optimized microemulsion formulation of griseofulvin
for topical application. Colloids Surf B Biointerfaces 2013;105:158-66.
Moghimipour E, Salimi A, Hassanvand S. Permeability assessment of
griseofulvin microemulsion through rat skin. Int J Pharm Chem Biol
Sci 2013;3(4):1061-5.
U.S. National Library of Medicine. Griseofulvin-Griseofulvin Tablet;
Available from: http://www.dailymed.nlm.nih.gov/dailymed/
drugInfo.cfm?setid=6149c044-58bb-402c-a4b5-18b96dd9b3b9. [Last
accessed on 2016 Jan 11].
Sinko PJ. Farmasi Fisika dan Ilmu Farmasetika. 5th ed. Jakarta: Buku
Kedokteran EGC; 2006.
Maya L. Pembuatan sediaan mikroemulsi dari minyak buah merah
(Pandanus conoideus). Skripsi. Depok: Universitas Indonesia; 2006.
Lachenmeier DW. Safety evaluation of topical applications of ethanol
on the skin and inside the oral cavity. J Occup Med Toxicol 2008;3:26.
Shinde U, Pokharkar S, Modani S. Design and evaluation of
microemulsion gel system of nadifloxacin. Indian J Pharm Sci
;74(3):237-47.
Kumar A, Kushwaha V, Sharma PK. Pharmaceutical microemulsion:
Formulation, characterization and drug deliveries across skin. Int J
Drug Dev Res 2014;6(1):1-21.
Júnior AA, Baldo JB. The behavior of zeta potential of silica
suspensions. N J Glass Ceram 2014;4:29-37.