COMBINATION OF HPMC AND PEG 400 AS A TASTE MASKING AGENT OF FILM-COATED TABLETS CONTAINING MOMORDICA CHARANTIA LINN. EXTRACT
DOI:
https://doi.org/10.22159/ijap.2018v10i3.24025Keywords:
Momordica charantia Linn Extract, Bitter taste masking, Film-coated tablet, HPMC, PEG 400Abstract
Objective: The objective of this study was to formulate and prepare film-coated tablets containing Momordica charantia Linn. to mask its bitter taste.
Methods: The core tablets of Momordica charantia Linn. were prepared by wet granulation method using sodium carboxymethyl cellulose (CMC-Na) as a binder, and then coated with hydroxypropyl methyl cellulose (HPMC) 5%. Film coating formulation was made in 3 formulae using the additional amount of polyethylene glycol (PEG) 400 as the plasticizer at 16%, 20%, and 24% concentration of HPMC weight. The obtained film-coated tablet was evaluated including organoleptic, the percentage of weight increase, surface morphology, coating thickness, disintegration time, and taste masking evaluation. Taste masking evaluation was performed on 30 respondents by giving the bitter taste level questionnaire of the three formulae film-coated tablets, core, and extract powders.
Results: Film-coated tablets that coated by using 20% PEG 400 as plasticizer had 4.78% of weight increase. The surface morphology was smooth and showed±34.67 µm of coating thickness. Furthermore, it also disintegrated within 5.34±1.1 min and successfully masked the bitter taste.
Conclusion: Combination of HPMC and PEG 400 20% as a plasticizer can give a good appearance and masked the bitter taste of Momordica charantia Linn.
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References
Tan HF, Gan CY. Polysaccharide with antioxidant, α-amylase inhibitory and ACE inhibitory activities from Momordica charantia. Int J Biol Macromol 2016;85:487–96.
Amira K, Aminah A, Zuhair A. Evaluation of bitter melon (Momordica charantia) extract administration in the antioxidant and free radical scavenging activities of plasma and liver in the male rat. Int Food Res J 2013:319-23.
Drewnoswski A, Carneros C. Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 2000;72:1424-35.
Sharma S, Tandon S, Semwal B, Singh K. Momordica charantia linn.: a comprehensive review on the bitter remedy. J Pharm Res Opin 2011;1:42-7.
Nagarani G, Abirami A, Siddhuraju P. Food prospects and nutraceutical attributes of momordica species: potential tropical bioresources–a review. Food Sci Human Wellness 2015;3:117-26.
Semiz A, Sen A. Antioxidant and chemoprotective properties of Momordica charantia L. (bitter melon) fruit extract. Afr J Biotech 2007;6:273–7.
Gupta M, Sharma S, Gautam AK, Bhadauria R. Review article: Momordica charantia Linn. Int J Pharm Sci Rev Res 2011;11:32-7.
Sharma S, Lewis S. Taste masking technologies: a review. Int J Pharm Pharm Sci 2010;2:6-13.
Sonar YA, Bele MH, Sonar NH, Bagul VS, Shimpi PS. Taste abatement and characterization of dispersible tablets of artemether prepared by hot melt extrusion. Int J Appl Pharm 2017;9:28-33.
Navveen RM, Priya B. Optimization of drying methods for bitter gourd (Momordica charantia L.) extract. Indian J Sci 2016; 22:574-82.
Banker GS, Anderson NR. Tablet in the theory and practice of industrial pharmacy. In: Lachman L, Lieberman HA, Kanig JL, Jakarta: UI Press; 1990.
Ansel H, Popovich N, Allen J. Pharmaceutical dosage form and drug delivery systems (6th ed.). USA: Williams and Wilkins; 1995.
Lachman L, Lieberman H, Schwartz J. Pharmaceutical dosage form: tablets. Vol. 3. (2nd ed.). USA: Marcel Dekker; 1990.
United States Pharmacopoeia Convention. The United States Pharmacopoeia, 38th and the National Formulary, 33rd. Rockville: United States Pharmacopoeia Convention, Inc; 2014.
Datrange P, Kulkarni S, Padalkar RR. Development of taste masked formulation for bitter drug. Res J Pharm Biol Chem Sci 2012;3:727–53.
Alghabban FM, Alani IH, Hassan SF. Taste masking of prifinium bromide in orodispersible tablets. Int J Pharm Pharm Sci 2014;S1:315-9.
United States Pharmacopoeia Convention. The United States Pharmacopoeia, 32nd and The National Formulary. 27th (1st ed.). Rockville: United States Pharmacopoeia Convention, Inc; 2009.
British Pharmacopoeia Commission. British Pharmacopoeia. London: Crown; 2007.
Rowe R, Sheskey P, Quinn M. Handbook of Pharmaceutical Excipients (6th ed.). London: Pharmaceutical Press; 2009.
Felton AL. Remington Essentials of Pharmaceutics. Pharmaceutical Press: 1st; 2013. p. 46, 169.
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