EFFECT OF MENTHOL ON THE TRANSDERMAL PERMEATION OF ACECLOFENAC FROM MICROEMULSION FORMULATION

Abdul Baquee Ahmed; Gouranga Das

doi:10.22159/ijap.2019v11i2.30988

Authors

Abdul Baquee Ahmed Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati, Assam 781017
Gouranga Das Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati, Assam 781017

DOI:

https://doi.org/10.22159/ijap.2019v11i2.30988

Keywords:

Menthol, Microemulsion, Transdermal flux, Surfactant, Co-surfactant

Abstract

Objective: The aim of this investigation was to enhance the transdermal permeation of aceclofenac (ACF) from microemulsion formulation using menthol as a natural permeation enhancer.

Methods: Microemulsion containing 2% w/v of ACF was prepared by a titration method with different concentration of oil, surfactant and co-surfactant. The prepared microemulsion was evaluated for droplet size, viscosity, pH and in vitro skin permeation studies. Menthol at 3-8% w/w was added to the selected microemulsion formulation and their effect on skin permeation was evaluated across rat epidermis using modified Keshary-Chien diffusion cell. The Fourier transform infrared spectroscopy (FT-IR) was performed to understand the regulation action of menthol in the skin permeability barrier.

Results: The average droplet size of the microemulsion was found to be 89.4±2.12 to 175.2±3.10 nm. The transdermal flux of the microemulsion containing 8% w/w menthol showed 2.9 fold increases in transdermal flux of ACF compared with the formulation without menthol. Result of FT-IR studies showed decrease in peak height of the symmetric and asymmetric C-H stretching vibrations may be because of the extraction of the stratum corneum (SC) lipids and the alteration of the skin permeability barrier.

Conclusion: This result suggests that menthol significantly enhanced the transdermal permeation of ACF and may be an effective natural penetration enhancer for transdermal delivery of the drug.

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Author Biography

Abdul Baquee Ahmed, Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati, Assam 781017

Pharmaceutical Sciences

HOD, Department of Pharmaceutics

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