COPROCESSED EXCIPIENTS OF CROSSLINKED AMYLOSE AND XANTHAN GUM FOR USE IN CONTROLLED RELEASE DOSAGE FORMS
DOI:
https://doi.org/10.22159/ijap.2018.v10s1.13Keywords:
Coprocessing, Crosslinking, High-amylose starch, Xanthan gum, Controlled release dosage formsAbstract
Objective: This study was aimed to obtain a new excipient that can be used as a polymer matrix for the formulation of controlled release dosage forms.
Methods: This study used coprocessing and crosslinking methods on amylose and xanthan gum (XG) to obtain a new excipient that can be used
for controlled release matrix of pharmaceutical dosage forms. The coprocessing step was conducted by drum drying, and the crosslinking step was
prepared using 6 and 12% sodium trimetaphosphate (STMP). The produced novel excipients were characterized in terms of infrared (IR) spectrum,
substitution degree, moisture content, swelling index, and gel strength.
Results: Our results showed that amylose–XG excipients crosslinked using 6% STMP have greater gel strength and better swelling indexes than
excipients crosslinked using 12% STMP. All coprocessed excipients exhibited no differences in their IR spectra, whereas the crosslinked excipients
did, indicating a structural change due to the addition of phosphate groups. Crosslinking amylose–xanthan-coprocessed excipients using 6% STMP
produced degrees of substitution (DSs) of 7–8 phosphates per 100 monomeric subunits. The excipients had a moisture content of 8.21–12.85%, and
the pH of a 1% solution of excipients was 6.21–6.43. In addition, the swelling index and gel strength of the excipient where both amylose and XG were
crosslinked together Were more than 1 where only amylose was crosslinked.
Conclusion: The crosslinking amylose–xanthan-coprocessed excipient using 6% STMP is more suitable for use in controlled release dosage forms,
particularly when the polymer ratio is 1:1.
Downloads
References
Ogaji IJ, Nep EI, Audu-Peter JD. Advances in natural polymers
as pharmaceutical excipients: Review article. Pharm Anal Acta
;3:1-16.
Acharya K, Khatua S, Mitra P. Free radical scavenging and nos
activation properties of water soluble crude polysaccharide from
Pleurotus ostreatus. Asian J Pharm Clin Res 2013;6:67-70.
Reddy PS, Bose PSC, Sruthi V, Saritha D. Investigation of kondagogu
gum to develop transdermal film of repaglinide. Asian J Pharm Clin
Res 2018;11:440-5.
Ofori-kwakye K, Amekyeh H, El-duah M, Kipo SL. Mechanical and
tablet coating properties of cashew tree (Anacardium occidentale L)
gum-based films. Asian J Pharm Clin Res 2012;5:62-8.
Carbinatto FM, de Castro AD, Cury BS, Magalhães A, Evangelista RC.
Physical properties of pectin-high amylose starch mixtures cross-linked
with sodium trimetaphosphate. Int J Pharm 2012;423:281-8.
Ferreira DD, Costa LA, Campos MI, Bispo MD, Krause LC,
Macedo ML, et al. Production of xantham gum from soybean biodiesel:
A preliminary study. BMC Proc 2014;8:P174.
Disha JS, Begum MH, Shawan WM, Khatun N, Ahmed S, Islam MS,
et al. Preparation and characterization of xanthan gum-based
biodegradable polysaccharide hydrogels. Res J Mater Sci 2016;4:13-8.
Soares GA, de Castro AD, Cury BS, Evangelista RC. Blends of crosslinked
high amylose starch/pectin loaded with diclofenac. Carbohydr
Polym 2013;91:135-42.
Heo H, Lee YK, Chang YH. Effect of cross-linking on physicochemical
and in vitro digestibility properties of potato starch. Emirates J Food
Agric 2017;29:463-9.
Lenaerts V, Moussa I, Dumoulin Y, Mebsout F, Chouinard F, Szabo P,
et al. Cross-linked high amylose starch for controlled release of drugs:
Recent advances. J Control Release 1998;53:225-34.
Ispas-Szabo P, Ravenelle S, Hassan I, Preda M, Mateeschu MA.
Structure–properties relationship in cross-linked high-amylose starch
for use in controlled drug release. Carbohydr Res 2000;323:163-75.
Bejenariu A, Popa M, Dulong V, Picton L, Cerf DL. Trisodium
trimetaphosphate crosslinked xanthan networks: Synthesis, swelling,
loading, and releasing behavior. Polym Bull 2009;62:525-38.
Nachaegari KS, Bansal AK. Coprocessed excipients for solid dosage
form. Pharm Technol 2004;14:54-8.
Vodackova P, Vranikova B, Svacinova P, Franc A, Elbi J, Muselik J,
et al. Evaluation and comparison of three types of spray dried
coprocessed excipient Avicel ® for direct compression. Biomed Res Int
;3:1-15.
Saha SS, Shahiwala AF. Multifunctional co-processed excipients
for improved tableting performance. Expert Opin Drug Deliv
;6:197-208.
Cury BS, Klein ST, Evangelista RC. Modeling a system of phosphated
cross-linked high amylosefor controlled drug release. Part 1: Synthesis
and polymer characterization. React Funct Polym 2008;68:1200-6.
Vliegenthart JF, van de Burg YE, Bergsma J, Bleeker IP, Mijland PJ,
Kamerling JP. Structural studies on methylated starch granules. Rev
Starch/Starke 1988;52:40-3.
Published
How to Cite
Issue
Section
