CROSS-SECTIONAL STUDY OF ASSOCIATION BETWEEN GLYCEMIC CONTROL AND QUALITY OF LIFE AMONG DIABETIC PATIENTS

Authors

  • Anita Natasya Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Retnosari Andrajati Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Rani Sauriasari Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia

DOI:

https://doi.org/10.22159/ijap.2018.v10s1.19

Keywords:

Type 2 diabetes mellitus, Quality of life, Hemoglobin A1c, Glycemic control, 5-Level EuroQol 5-dimensional

Abstract

Objective: The present study aimed to evaluate the association between glycemic control and quality of life (QoL) in people with type 2 diabetes
mellitus (T2DM) and identify that factors that influence glycemic control and QoL.
Methods: This cross-sectional study was conducted at the general hospital in Depok City from October to December 2017. Respondents were
outpatients diagnosed with T2DM, receiving routine care at the hospital. Glycemic control was assessed using glycated hemoglobin (HbA1c) levels,
while QoL was measured using an Indonesian version of the validated 5-level EuroQol 5-Dimensional.
Results: Among 108 participants, HbA1c levels were influenced by age, DM disease duration, DM treatment adherence, glycemic control, diet, and
physical activity suitable for patients with DM. The mean QoL value was 0.74±0.23 and the visual analog scale (VAS) score was 65.49±15.96. The QoL
values of patients with DM were influenced by HbA1c levels, duration of DM, and physical activity, while the VAS score was significantly affected by
HbA1c levels and duration of DM.
Conclusion: The present study showed that the QoL of T2DM patients was significantly influenced by glycemic control and other factors.

Downloads

Download data is not yet available.

References

World Health Organization. Global Report on Diabetes. Geneva: World

Health Organization; 2015. Available from: http://www.apps.who.int/

iris/bitstream/10665/204871/1/9789241565257_eng.pdf. [Last cited on

Apr 28].

Larasati TA. Quality of life patient with diabetes melitus Type 2 in

Abdul Moeloek hospital province lampung. J Kedokteran Kesehatan

Univ Lampung 2012;2:17-20.

World Health Organization. Global Health Observatory (GHO)

Data: Mortality and Global Health Estimates. Geneva: World Health

Organization; 2015. Available from: http://who.int/gho/mortality_

burden_disease/en. [Last cited on 2017 Apr 28].

Ostgren C, Lindbland U, Ranstam J, Melander A, Rastam L. Glycemic

control, disease duration and β-cell function in patients with type 2

diabetes in a Swedish community. Diabetes Med 2002;19:125-9.

Wang P, Luo N, Tai ES, Thumboo J. The EQ-5D-5L is more

discriminative than the EQ-5D-3L in patients with diabetes in

Singapore. Value Health Reg Issues 2016;9:57-62.

American Diabetes Association. Standards of medical care in

diabetes-2017. Diabetes Care 2017;40 Suppl 1:S1-35.

Shah BM, Mezzio DJ, Ho J, Ip EJ. Association of ABC (HbA1c, blood

pressure, LDL-cholesterol) goal attainment with depression and healthrelated

quality of life among adults with Type 2 diabetes. J Diabetes

Complications 2015;29:794-800.

AminiLari Z, Fararouei M, Amanat S, Sinaei E, Dianatinasab S,

AminiLari M, et al. The effect of 12 weeks aerobic, resistance, and

combined exercises on omentin-1 levels and insulin resistance among

Type 2 diabetic middle-aged women. Diabetes Metab J 2017;41:205-12.

Aro AK, Karjalainen M, Tiihonen M, Kautiainen H, Saltevo J,

Haanpää M, et al. Glycemic control and health-related quality of life

among older home-dwelling primary care patients with diabetes. Prim

Care Diabetes 2017;11:577-82.

EuroQol Research Foundation. EQ-5D Instruments: About EQ-5D.

Rotterdam: EuroQol Research Foundation; 2017. Available from:

https://www.euroqol.org/deq-5d-instruments. [Last cited 2017 Apr 28].

Bourdel-Marchasson I, Druet C, Helmer C, Eschwege E, Lecomte P,

Le-Goff M, et al. Correlates of health-related quality of life in French

people with Type 2 diabetes. Diabetes Res Clin Pract 2013;101:226-35.

Sakamaki H, Ikeda S, Ikegami N, Uchigata Y, Iwamoto Y, Origasa H,

et al. Measurement of HRQL using EQ-5D in patients with Type 2

diabetes mellitus in Japan. Value Health 2006;9:47-53.

Triplitt CL, Reasner CA. Diabetes mellitus. In: Dipiro JT, Talbert RL,

Yee GC, Matzke GR, Wells BG, Posey LM, editors. Pharmacotherapy.

A Pathophysiologic Approach. 10th ed. New York: The McGraw-Hill

Medical; 2017. p. 3212-92.

Kuznetsov L, Griffin SJ, Davies MJ, Lauritzen T, Khunti K, Rutten GE,

et al. Diabetes-specific quality of life but not health status is

independently associated with glycaemic control among patients with

type 2 diabetes: A cross-sectional analysis of the ADDITION-Europe

trial cohort. Diabetes Res Clin Pract 2014;104:281-7.

Purba FD, Hunfeld JA, Iskandarsyah A, Fitriana TS, Sadarjoen

SS, Ramos-Goñi JM, et al. The Indonesian EQ-5D-5L value set.

Pharmacoeconomics 2017;35:1153-65.

Endarti D, Riewpaiboon A, Thavorncharoensap M, Praditsitthikorn N,

Hutubessy R, Kristina SA, et al. A comparison of EQ-5D-3L index scores

using Malaysian, Singaporean, Thai, and UK value sets in Indonesian

cervical cancer patients. Value Health Reg Issues 2018;15:50-5.

Lemeshow S, Hosmer DW, Klar J, Lwanga SK. Adequacy of Sample

Size in Health Studies. England: World Health Organization; 1990.

Rwegerera G, Moshomo T, Gaenamong M, et al. Health-related quality

of life and associated factors among patients with diabetes mellitus in

Botswana. AJM 2017;54:111-8.

Vidal-Peracho C, Lucha-López MO, Lucha-López AC,

Tricás-Moreno JM, Estébanez-De Miguel E, Bernués-Vázquez L, et al.

A descriptive study of health status and health related quality of life in

selected outpatients with type 2 diabetes, pathological body mass index

and cardiovascular risk in Spain. Diabetol Metab Syndr 2014;6:135.

Parsa P, Ahmadinia-Tabesh R, Mohammadi Y, Khorami N. Investigating the

relationship between quality of life with lipid and glucose levels in Iranian

diabetic patients. Diabetes Metab Syndr 2017;11 Suppl 2:S879-S883.

Ma Q, Liu H, Xiang G, Shan W, Xing W. Association between glycated

hemoglobin A1c levels with age and gender in Chinese adult with no

prior diagnosis of diabetes mellitus. Biomed Rep 2016;4:737-40.

Babazadeh T, Dianatinasab M, Daemi A, Nikbakht HA, Moradi F,

Ghaffari-Fam S, et al. Association of self-care behaviors and quality

of life among patients with Type 2 diabetes mellitus: Chaldoran county,

Iran. Diabetes Metab J 2017;41:449-56.

Heintz E, Wiréhn AB, Peebo BB, Rosenqvist U, Levin LÅ. QALY

weights for diabetic retinopathy – a comparison of health state

valuations with HUI-3, EQ-5D, EQ-VAS, and TTO. Value Health

;15:475-84.

Published

20-12-2018

How to Cite

Natasya, A., Andrajati, R., & Sauriasari, R. (2018). CROSS-SECTIONAL STUDY OF ASSOCIATION BETWEEN GLYCEMIC CONTROL AND QUALITY OF LIFE AMONG DIABETIC PATIENTS. International Journal of Applied Pharmaceutics, 10(1), 92–96. https://doi.org/10.22159/ijap.2018.v10s1.19

Issue

Section

Original Article(s)