PREPARATION OF POWDER FROM BROWN SEAWEED (SARGASSUM PLAGYOPHYLLUM) BY FREEZE-DRYING WITH MALTODEXTRIN AS A STABILIZER

Authors

  • Effionora Anwar Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Hilmia Erianto Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Kurnia Sari Setio Putri Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.

DOI:

https://doi.org/10.22159/ijap.2018.v10s1.77

Keywords:

Phlorotannin, Freeze-drying, Sargassum plagyophyllum, Nil

Abstract

Objective: The aim of this study was to prepare powder from liquid extract with maltodextrin dextrose equivalent 10–15 as a stabilizer using a freezedrying
method to maintain stability during drying process and extend storage time.
Methods: Powders were prepared for four formulas: F1 (without maltodextrin), F2 (2.5% maltodextrin), F3 (5% maltodextrin), and F4 (10%
maltodextrin). Powder from the four formulas was characterized by its phlorotannin concentration, antioxidant activity, water content, morphology,
particle size distribution, pH, and organoleptic activities.
Results: F4 was the best formula because it contained the highest phlorotannin concentration (113.06±1.36) or 0.25%, highest percentage of
inhibition concentration50 (IC50) (4.06% at a concentration of 5000 ppm), and lowest water content (5.16%); moreover, in a stability test, F4 exhibited
a more stable phlorotannin concentration and lower water content than F1, with an optimal storage temperature of 4°C.
Conclusion: Maltodextrin can improve the stability bioactive compounds during the freeze-drying process and storage time.

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References

Wouthuyzen S, Herandarudewi SM, Komatsu T. Stock assessment of

brown seaweeds (Phaeophyceae) along the bitung-bentena coast, North

Sulawesi Province, Indonesia for alginate product using satellite remote

sensing. Proc Environ Sci 2016:33;553-61.

Li Y, Wijesekara I, Li Y, Kim S. Phlorotannins as bioactive agents from

brown algae. Process Biochem 2012;46:2219-24.

Vo T, Ngo D, Kim S. Marine algae as a potential pharmaceutical source

for anti-allergic therapeutics. Process Biochem 2012;47:386-94.

Zubia M, Sophie M, Kerjean V, Le K, Stiger-pouvreau V, Fauchon M,

et al. Antioxidant and antitumoural activities of some Phaeophyta from

Brittany coasts. Food Chem 2009;116:693-701.

Mohamed S, Hashim SN, Rahman A. Seaweeds: A sustainable

functional food for complementary and alternative therapy. Trends

Food Sci Technol 2012;23:83-96.

Bakowska-barczak AM, Kolodziejczyk PP. Black currant polyphenols :

Their storage stability and microencapsulation. Ind Crops Prod

;34:1301-9.

Khan F, Bafna S, Gupta T, Arnold EI. Virtual screeing of potential

inhibitors from herbs for the treatment of breast cancer. Asian J Pharm

Clin Res 2017;10:62-7.

William H, Narayanan N. Comparative evaluation of antioxidant activity

of substituted flavones. Asian J Pharm Clin Res 2017;10:288-91.

Rajendran S, Nithya G, Brindha DP, Kanakam CC. Docking antioxidant Pharm Clin Res 2017;10:263-5.

Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical

Excipients. 6th ed. USA: Pharmaceutical Press and American

Pharmacists Association; 2009.

Pilcer G, Amighi K. Formulation strategy and use of excipients in

pulmonary drug delivery. Int J Pharm 2010;392:1-19.

Masduqi AF, Izzati M, Prihastanti E. The effect of the drying method

on seaweed chemical content Sargassum polycystum. Bul Anat Fisiol

;22:1-9.

Ye H, Zhou C, Sun Y, Zhang X, Liu J, Hu Q, et al. Antioxidant activities

in vitro of ethanol extract from brown seaweed Sargassum pallidum.

Eur Food Res Technol 2009;230:101-9.

Frecha-ferreiro S. Antioxidant compounds in edible brown seaweeds.

Eur Food Res Technol 2001;231:495-8.

Caliskan G, Dirim SN. The effect of different drying processes and the

amounts of maltodextrin addition on the powder properties of sumac

extract powders. Powder Technol 2016;287:308-14.

Published

20-12-2018

How to Cite

Anwar, E., Erianto, H., & Putri, K. S. S. (2018). PREPARATION OF POWDER FROM BROWN SEAWEED (SARGASSUM PLAGYOPHYLLUM) BY FREEZE-DRYING WITH MALTODEXTRIN AS A STABILIZER. International Journal of Applied Pharmaceutics, 10(1), 348–353. https://doi.org/10.22159/ijap.2018.v10s1.77

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Original Article(s)