EFFECTS OF ODONTOCEM AND MINERAL TRIOXIDE AGGREGATE-ANGELUS TOXICITY ON FIBROBLAST VIABILITY

DEWI SRI KESUMAWATI; ANGGRAINI MARGONO; ENDANG SUPRASTIWI

doi:10.22159/ijap.2019.v11s1.AR158

Authors

DEWI SRI KESUMAWATI Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
ANGGRAINI MARGONO Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
ENDANG SUPRASTIWI Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

DOI:

https://doi.org/10.22159/ijap.2019.v11s1.AR158

Keywords:

Fibroblast cells, Toxicity, Odontocem, Mineral Trioxide Aggregate

Abstract

Objective: Mineral trioxide aggregate (MTA) is proven to be biocompatible and is used for pulp capping treatment. Odontocem, calcium silicate-based
cement similar to MTA with the addition of a steroid, has recently been developed and to compare the effects of Odontocem and MTA-Angelus toxicity
on fibroblast cell viability.
Methods: Fibroblast cells from embryonated chicken eggs were immersed in Odontocem or MTA-Angelus solution for 24 and 72 h. Cell viability was
analyzed by Microculture Tetrazolium (MTT) 3-(4,5-dimethylthiazol-2- yl)2,5-diphenyltetrazolium bromide assay.
Results: After 24 h, the Odontocem and MTA-Angelus groups showed significantly lower viability (p<0.05) compared with controls. After 72 h, cell
viability was significantly higher in the Odontocem and MTA-Angelus groups. However, there was no significant difference between the Odontocem
and MTA-Angelus groups.
Conclusions: Odontocem and MTA-Angelus have low toxicity for dental applications.

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