FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS (ODTS) OF DICLOFENAC SODIUM BY USING SUPERDISINTEGRANT FROM NATURAL ORIGIN

SATYAJITH PANDA; NODAGALA HEMALATHA; PANCHAGNULA UDAYA SHANKAR; SRINIVASA RAO BARATAM

doi:10.22159/ijap.2019v11i6.33480

Authors

SATYAJITH PANDA Maharaja’s College of Pharmacy, Andhra University, Phoolbaugh, Vizianagaram, Andhra Pradesh, 535002, India
NODAGALA HEMALATHA Maharaja’s College of Pharmacy, Andhra University, Phoolbaugh, Vizianagaram, Andhra Pradesh, 535002, India
PANCHAGNULA UDAYA SHANKAR Maharaja’s College of Pharmacy, Andhra University, Phoolbaugh, Vizianagaram, Andhra Pradesh, 535002
SRINIVASA RAO BARATAM St. Ann’s College of Pharmacy, Cantonment, Andhra University, Vizianagaram, Andhra Pradesh, 535003, India

DOI:

https://doi.org/10.22159/ijap.2019v11i6.33480

Keywords:

Diclofenac sodium, Pigeon starch, Sodium starch glycolate, Orodispersible tablets (ODTs)

Abstract

Objective: In this study, a polysaccharide isolated from the seeds of Cajanus cajan (pigeon pea) was investigated as a super disintegrant in the orodispersible tablets of diclofenac sodium.

Methods: Diclofenac sodium tablets were prepared separately using different concentrations (5%, 7.5%, 10%, and 15% w/w) of isolated Cajanus cajan seed polysaccharide (natural) and sodium starch glycolate (synthetic) as super disintegrant by the direct compression method. Evaluation of tablets was done for various pre-and post-compression parameters. The stability studies were performed on optimized formulation F5. The disintegration time and in vitro drug release of the formulation F5 was compared with pregelatinized starch and synthetic super disintegrant (sodium starch glycolate).

Results: The drug-excipient interactions were characterized by Fourier transform infrared studies. The Optimized formulation F5 containing 15% polysaccharide showed wetting time of 118.7 seconds with 105.3 seconds of disintegration time and 95.61% dissolved in 3 min.

Conclusion: The present work revealed that Cajanus cajan seed polysaccharide has a good disintegrating agent in the formulation of orodispersible tablets.

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