EFFECT OF CELLULOSIC POLYMER ON PHYSICO MECHANICAL PROPERTIES OF SUPERPOROUS HYDROGEL OF AN ANTIHYPERTENSIVE DRUG AND DRUG RELEASE KINETICS FROM IT
DOI:
https://doi.org/10.22159/ijap.2019v11i5.34734Keywords:
Super porous hydrogel, Gastro retentive, Porosity, Higuchi, Korsmeyer-Peppas, Diffusion, Kopcha KineticsAbstract
Objective: Super porous hydrogels (SPHs), a novel drug delivery system can be developed to retain drugs in the gastric medium. The aim of the present investigation was to prepare superporous hydrogels (SPHs) of Atenolol to release the drug in sustained manner in the gastric environment and study the effect of two grades of hydroxyl methyl cellulose along with Carbopol 971p on the physico mechanical properties and drug release kinetics of the formulations.
Methods: Superporous hydrogels of Atenolol were prepared with two grades of Hydroxy Propyl Methyl Cellulose (HPMC K100M and HPMC K15 M) along with Carbopol 971p the structural morphology of hydrogel was observed by Scanning Electron Microscopy. Study on Physico mechanical characteristics and drug release were done.
Results: Scanning Electron microscopy studies of the formulations revealed the presence of large number of pores in different size ranges like 1 µm, 2 µm, 10 µm, confirming the formulations as superporous hydrogel. A correlation had been found between porosity, density and % swelling index. The drug release data from the formulations obeyed Higuchi and Korsmeyer-Peppas kinetics. Further, the data were fitted to the Kopcha model for confirming drug release by a combination of diffusion-controlled and chain relaxation–swelling mechanism.
Conclusion: Among the six formulations, where HPMC K15 M and HPMC K100 M both were present, the gel became more hydrophobic and retarded the release of drug. From the drug release kinetics data, it can be concluded that the diffusion mechanism predominated the drug release process, leading to quasi diffusion and Fickian diffusion mechanism.
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References
Allan SH. Hydrogels for biomedical applications. Adv Drug Delivery Rev 2002;43:3-12.
Chen J, Park H, Park K. Synthesis of superporous hydrogels: hydrogels with fast swelling and superabsorbent properties. J Biomed Mater Res 1999;44:53-62.
Yong Q, Park K. Superporous IPN hydrogels having enhanced mechanical properties. AAPS PharmSciTech 2003;4:406-12.
Reddy AM, Narsimharao N, Srinivasababu P, Navyasri N, Reddy AA. Formulation and characterization of super porous hydrogel of Nizatidine. Indian J Res Pharm Biotech 2015;3:341-50.
Chen J, Park K. Synthesis and characterization of superporous hydrogels composites. J Controlled Release 2000;65:73-82.
Sharma PK, Asthana GS, Asthana A. Hydrogel advancement: a new approach for gastroretentive drug delivery. Int J Pharm Clin 2016;8:1418-22.
Akhtar MF, Hanif M, Ranjha NM. Methods of synthesis of hydrogels, a review. Saudi Pharml J 2016;24:554–6.
Niharika MG, Krishnamoorthy K, Akkala M. Overview on floating drug delivery system. Int J Appl Pharm 2018;10:65-71.
Vadia N, Rajput AS. Mesoporous material, mcm¬ 41: a new drug carrier. Asian J Pharm Clin Res 2011;4:44-¬53.
Dantas MGB, Reis SA, Damasceno GB, Damasceno CMD. Development and evaluation of stability of a gel formulation containing the monoterpene borneol. Sci World J 2016. Doi:10.1155/2016/7394685
Farid AD, Verhoef JC, Borchard G, Rafiee MT, Hans EJ. Development and characterization of a novel peroral peptide drug delivery system. J Controlled Release 2001;71:307-18.
Köse GT, Kenar H, Hasirci N, Hasirci V. Macroporous poly (3-hydroxybutyrate-co-3-hydroxyvalerate) matrices for bone tissue engineering. Biomaterials 2003;24:1949-58.
Gupta NV, Shivakumar HG. Preparation and characterization of superporous hydrogels as gastroretentive drug delivery system for rosiglitazone maleate. DARU 2010;18:200-10.
Deore LP, Devidas GB. Superporous hydrogel (SPH): an innovative approach of gastro retention. Res J Pharm Bio Chem Sci 2013;4:261-75.
Chavda HV, Patel CN. Preparation and characterization of swellable polymer-based superporous hydrogel composite of poly (Acrylamide-co-Acrylic Acid). Trends Biomater Artif Organs 2010;24:83-9.
Majee SB, Avlani D, Biswas GR. HPMC as capsule shell material: physicochemical, pharmaceutical and biopharmaceutical properties. Int J Pharm Pharm Sci 2017;9:1-6.
Rajab NA, Jawad MS. Formulation and in vitro evaluation of piroxicam microsponge as a tablet. Int J Pharm Pharm Sci 2015;8:104-10.
Muthuswamy R, Deepan D. Formulation and evaluation of superporous hydrogel tablet rabeprazole sodium as gastroretentive drug. Eur J Pharm Med Res 2018;5:271-8.
Mukherjee B, Das S, Patra B, Layek B. Nefopam containing transdermal-matrix patches based on pressure-sensitive adhesive polymers. PharmTech 2006;30:146-63.
Bonardi AH, Bonardi F, Morlet S. Photoinduced thermal polymerization reactions. Macromolecules 2018. Doi:10.1021/acs.macromol.8b01741
Kumar A, Pandey M, Mamman K, Saraf S. Synthesis of fast swelling superporous hydrogel: effect of concentration of crosslinker and acdisol on swelling ratio and mechanical strength. Int J Drug Delivery 2011;2:135-5.
Naziha C, Lhocine Y, Lukas G, Federico LM, Soumia C, Silvia F. History and applications of hydrogels. J Biomed Sci 2015;4:1.
Hebbar S, Dubey A, Ravi GS, Mascarenhas SB. Studies on cross-linked chitosan hydrogel for matrix tablets of montelukast sodium. Int J Appl Pharm 2017;9:22-7.
Babu BR, Kilaru NB. An unified mathematical expression for ideal peppas model: prospective estimation of percent deviation. Asian J Pharm Tech 2016;6:189-7.
Kopcha M, Lordi NG, Tojo KJ. Evaluation of release from selected thermo softening vehicles. J Pharm Pharmacol 1999;43:382-7.
Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release. Chem Rev 2016;116:2602-63.
Gohel MC, Ramkishan A, Patel TM, Pandya R, Suthar V, Koradia H, et al. Nomogram for computing the value of similarity factor. Indian J Pharm Sci 2014;76:245–51.
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