BIO-NANOPARTICLES: GREEN SYNTHESIS OF GOLD NANOPARTICLES AND ASSESSMENT OF BIOLOGICAL EVALUATION

Authors

  • RATIH DYAH PERTIWI Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, Jl Arjuna no 9A Jakarta, 11510, Doctoral Program in Pharmaceutical Science, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia 55281
  • SUWALDI Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara Yogyakarta, 55281
  • ERNA PRAWITA SETYOWATI Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281
  • RONNY MARTIEN Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara Yogyakarta, 55281

DOI:

https://doi.org/10.22159/ijap.2019v11i6.34826

Keywords:

Green synthesis, Gold Nanoparticles, Antioxidant, Muntingia calabura, Biological activities

Abstract

Objective: The design like bio-nano particles are beneficial over chemical and physical composition due to the eco-friendly and lower-cost synthesis of nanoparticles. The current study was purposed for the biosynthesis of gold nanoparticles (GNPs) and their antioxidant evaluation.

Methods: Aqua extract of Muntingia calabura, Linn was applied for the synthesis of GNPs and confirmed by UV visible and ATR-Fourier Transform Infra-Red (ATR-FTIR) spectroscopy. Transmission Electron Microscope and Particle Size Analyser were used for the shape zeta potential and determination of size. Antioxidant activity was examined by DPPH (1,1 diphenyl-2-picryl-hydrazyl) radical scavenging method.

Results: The result showed that UV–vis absorption spectra of H Au Cl4 at 290 nm while absorption spectra of biosynthesis gold nanoparticles at 540 nm. The forming of nanoparticles were spherical, having an average particle size of 88 nm, and the result of zeta potential was 9.5 mV. Analysis of ATR-FTIR revealed the possible involvement of phytochemical constituents in gold nanoparticles of aqua extract. Green synthesized nanoparticles showed enhanced antioxidant properties.

Conclusion: Green synthesized GNPs showed enhanced biological activities. Present results also support the benefit of using the biosynthesis method for the production of gold nanoparticles that have the potential of antioxidant and biology activities.

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Published

07-11-2019

How to Cite

PERTIWI, R. D., SUWALDI, SETYOWATI, E. P., & MARTIEN, R. (2019). BIO-NANOPARTICLES: GREEN SYNTHESIS OF GOLD NANOPARTICLES AND ASSESSMENT OF BIOLOGICAL EVALUATION. International Journal of Applied Pharmaceutics, 11(6), 133–138. https://doi.org/10.22159/ijap.2019v11i6.34826

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