EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN-β-CYCLODEXTRIN INCLUSION COMPLEX

NUR AINI DEWI PURNAMASARI; PRATAMA ANGGI SAPUTRA

doi:10.22159/ijap.2020v12i2.34848

Authors

NUR AINI DEWI PURNAMASARI Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Setia Budi, Surakarta, Indonesia
PRATAMA ANGGI SAPUTRA Faculty of Pharmacy, Universitas Setia Budi, Indonesia

DOI:

https://doi.org/10.22159/ijap.2020v12i2.34848

Keywords:

Ibuprofen, Inclusion complexes, Nil, ODT and super disintegrant

Abstract

Objective: This study aims to determine the effect of the inclusion complex formation of ibuprofen (IB) with β-cyclodextrin (β-CD) in improving water solubility and taste masking as well as to study the effect of the combined use of super disintegrants in IB-β-CD ODT (Orally disintegrating tablet).

Methods: IB-β-CD inclusion complex was prepared by spray drying technique with a 1:1 molar ratio. ODTs were prepared by the direct compression method using various ratios of Ac-Di-Sol® and Kollidon® CL as super disintegrant. The inclusion complex was characterized using spectroscopy FT-IR (Fourier-transform infrared) and DSC (Differential Scanning Calorimetry). The physical properties and dissolution rate of ODTs were evaluated. Dissolved drug concentration at 60 min (Q₆₀) and Dissolution Efficiency (DE₆₀) was calculated using the dissolution test result.

Results: The unpleasant taste of IB had been successfully masked by IB-β-CD. Formula 1 was observed having 14.5 sec of disintegration, fastest compared to the other formulas. Moreover DE₆₀value of formula I was higher than the other formulas (113.45).

Conclusion: IB-β-CD Inclusion complex prepared by spray drying method (1: 1) increased the water solubility and masked the unpleasant taste compared to IB moreover combination of Ac-Di-Sol® and Kollidon® CL increased ODT dissolution rate.

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