THE IMPACT OF CASSYTHA FILIFORMIS BUTANOL FRACTION TO THE PREGNANCY AND FETAL DEVELOPMENT ON MICE
DOI:
https://doi.org/10.22159/ijap.2019.v11s5.T1010Keywords:
Cassytha filiformis, Pregnancy development, Fetal number, Death, Fetal defectAbstract
The impact of Cassytha filiformis butanol fraction to the pregnancy and fetal development had been conducted. The fertilized mice were treated with
butanol fraction of C. filiformis at doses of 2.5; 5; 10; and 20 mg/kg of body weight (BW) orally for 5 consecutive days during first, second, and third
periods of pregnancy. Parent BW was monitored and the fetal number, BW, death and/or resorptive site and defect were measured. ANOVA followed
by Duncan multiple range test (significance at p<0.05) was performed to analyze data. The parent weight was reduced according to fraction dose
and the period of pregnancy and the interaction of those factors (p<0.01). Only one mouse treated during the first period became pregnant with less
fetus number (p<0.05) but all of treated during the second and third period but death, resorptive site and underdeveloped fetus were found. These
indicated the butanol fraction of C. filiformis produced infertility and slowed pregnancy development and produce fetal defect on mice.
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Pharm Sci Res 2016;7:98.
2. Indonesian Ministry of Health. National Policy of Traditional
Medicine; 2007. Available from: http://www.binfar.depkes.go.id/dat/
lama/1206328790_Buku%20Kebijakan%20Obat%20Tradisional%20
Nasional%20Tahun%202007.pdf. [Last accessed on 2018 Sep 05].
3. Nelson SC. Cassytha filiformis, Plant Disease. Hawaii: Cooperative
Extension Service; 2008.
4. Mythili S, Gajalakshmi S, Sathiavelu A, Sridharan TB. Pharmacological
activities of Cassytha filiformis: A review. Asian J Plant Sci Res
2011;1:77-83.
5. Quetin-Leclercq J, Hoet S, Block S, Wautier MC, Stévigny C. Studies
on Cassytha filiformis from Benin: Isolation, Biological Activities and
Quantification of. Benin: In Proceedings of Bioresources Towards Drug
Discovery and Development; 2004. p. 81-107.
6. Adonu CC, Esimone CO, Attama AA, Ugwueze MC. In vitro evaluation
of anti bacterial activity of extracts from Cassytha filiformis linn
against urogenital clinical gram-negative bacteria. Int J Pharm Biol Sci
2013;3:99-107.
7. Armenia A, Yuliandra Y, Sattar MZ. Comparative effectiveness of
defatted hypotensive crude extract, ethyl acetate and butanolic fractions
of Cassytha filiformis L. On different models of hypertensive rats.
World J Pharm Pharm Sci 2014;3:200-8.
8. Yuliandra Y, Armenia A, Arifin H. Antihypertensive and antioxidant
activity of Cassytha filiformis L.: A correlative study. Asian Pac J Trop
Biomed 2017;7:614-8.
9. Armenia. Efek Ekstrak Butanol Tali Putri sebagai Antikoagulan Pada
Mencit Putih Jantan. Padang: Universitas Andalas; 2007.
10. Sahu RK, Roy A, Kothiya S, Maurya AK, Kumar R. Screening of
antipyretic and analgesic potential of ethanol extract of Cassytha
filiformis leaves. Res J Sci Technol 2012;4:129-31.
11. Babayi HM, Udeme JJ, Abalaka JA, Okogun JI, Salawu OA, Akumka D,
et al. Effect of oral administration of aqueous whole extract of Cassytha
filiformis on haematograms and plasma biochemical parameters in rats.
J Med Toxicol 2007;3:146-51.
12. Armenia A, Alen Y, Ismed F, Yuliandra Y, Fitria AR. Blood sugar
lowering effectiveness of Cassytha filiformis fractions on diabetic mice.
Res J Pharm Biol Chem Sci 2016;7:1142-7.
13. Tsai TH, Wang GJ, Lin LC. Vasorelaxing alkaloids and flavonoids from
Cassytha filiformis. J Nat Prod 2008;71:289-91.
14. Raj B, Singh SD, Samual VJ, John S, Siddiqua A. Hepatoprotective and
antioxidant activity of Cassytha filiformis against CCl4 induced hepatic
damage in rats. J Pharm Res 2013;7:15-9.
15. Karemore MN, Avari JG. Herbal medicines used during pregnancy,
childbirth and postpartum care. Int J Pharm Sci Res 2017;8:5326-35.
16. Gholami M, Moallem SA, Afshar M, Amoueian S, Etemad L, Karimi G,
et al. Teratogenic effects of silymarin on mouse fetuses. Avicenna J
Phytomed 2016;6:542-9.
17. Armenia A, Hercegovina H, Gustinanda D, Salasa AN, Yuliandra Y,
Ismed F. Acute and delayed toxicity study of Cassytha filiformis
defatted extract. World J Pharm Pharm Sci 2015;4:155-62.
18. Yuliandra Y, Arief R, Jannah MH, Arifin H. Reversible hepatotoxicity
of Cassytha filiformis extract: Experimental study on liver function and
propofol-induced sleep in mice. Pharm J 2019;11:69-74.
19. Yuliandra Y, Armenia N, Salasa AN, Ismed F. Subchronic toxicity of
ethanolic extract of Cassytha filiformis L. on the renal function of rat. J
Sains Farm Klin 2015;2:54-9.
20. WHO. WHO Traditional Medicine Strategy 2014-2023. Geneva: World
Health Organization; 2013.
21. Conour LA, Murray KA, Brown MJ. Preparation of animals for research
issues to consider for rodents and rabbits. ILAR J 2006;47:283-93.
22. BPOM. Pedoman Uji Toksisitas Nonklinis Secara In vivo. Jakarta:
Badan Pengawas Obat dan Makanan Republik Indonesia; 2005.
23. Almahdy A. Teratologi Ekperimental. Padang: Universitas Andalas
Pers Padang; 2012.
24. Bronson FH. The estrous cycle. In: Bronson FH, editor. Mammalian
Reproductive Biology. Chicago IL: University of Chicago Press; 1989.
p. 67-75.
25. Little BB. Drug and Pregnncy. Great Britain: Hodder Arnold; 2006.
26. Prasad GJ, Kalyani DC, Prakash GC. Teratogenicity: A mechanism
based short review on common teratogenic agents. Asian Pac J Trop
Dis 2014;4:421-32.
27. Sadler LD. Lagman’s Medical Embryology. 25th ed. Philadelphia, PA:
Wolters Kluwer Health; 2012.
28. Morrison JL, Regnault TR. Nutrition in pregnancy: Optimising
maternal diet and fetal adaptations to altered nutrient supply. Nutrients
2016;8:E342.
29. Bánhidy F, Lowry RB, Czeizel AE. Risk and benefit of drug use during
pregnancy. Int J Med Sci 2005;2:100-6.
30. Vonnahme KA, Lemley CO, Caton JS, Meyer AM. Impacts of maternal
nutrition on vascularity of nutrient transferring tissues during gestation
and lactation. Nutrients 2015;7:3497-523.
31. George P. Concerns regarding the safety and toxicity of medicinal
plants an overview. J Appl Pharm Sci 2011;1:40-4.
32. Shaw SWS, Cheng PJ, Chang YL, Chao AS, Wang TH, Chang SD,
et al. Human amniotic fluid stem cells have better potential in early
second trimester of pregnancy and can be reprogramed to iPS. Taiwan J
Obstet Gynecol 2017;56:770-4.
33. Harbinson RD. The Basic Science of Poison Cassaret and Doull’s
Toxicology. New York: Macmillan Publishing Co. Inc.; 2008.
34. McLaren A, Michief D. Super-pregnancy in the Mouse 2. Weight
Gain During Pregnancy by Anne McLaren and Donald Michief Royal
Veterinary College. London: University of London; 1959.
35. Calabrese EJ, Baldwin LA. Hormesis: U-shaped dose responses and
their centrality in toxicology. Trends Pharmacol Sci 2001;22:285-91.
36. Calabrese EJ. Hormesis and medicine. Br J Clin Pharmacol
2008;66:594-617.
Published
15-09-2019
How to Cite
NAZAR, A., AYUNING, F., & AHMADIN, A. (2019). THE IMPACT OF CASSYTHA FILIFORMIS BUTANOL FRACTION TO THE PREGNANCY AND FETAL DEVELOPMENT ON MICE. International Journal of Applied Pharmaceutics, 11(5), 153–156. https://doi.org/10.22159/ijap.2019.v11s5.T1010
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